D-ribose-L-cysteine modulates paradoxical sleep deprivation-induced neurological impairments: anxiolytic and antioxidative study in rat model

Abayomi, Taiwo Adekemi; Tokunbo, Olorunfemi; Oroyemi, Oluwatobiloba; Abayomi, Olawale Ayobami; Osuntokun, Opeyemi Samson; Falana, Benedict Abiola; Adeniyi, Temidayo

doi:10.1080/2314808x.2022.2065438

Cited by 2 publications

(1 citation statement)

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“…We further found that ribose-cysteine improves GST activity and increases total thiol levels and cell viability in the PD model. These effects could be traceable to ribose-cysteine’s ability to arrest ferroptosis [ 77 ] and to augment the mitochondrial glutathione pool, enhance mitochondrial complex activity [ 53 ], mop up free radicals, and thereby reduce oxidative stress [ 78 , 79 ]. The antioxidant activity of levodopa observed in this study may be due to its dopamine synthesis-enhancing property [ 24 , 65 ].…”

Section: Discussionmentioning

confidence: 99%

Ribose-cysteine and levodopa abrogate Parkinsonism via the regulation of neurochemical and redox activities in alpha-synuclein transgenic Drosophila melanogaster models

Idowu,

Oremosu,

Dosumu

et al. 2024

Fly

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Parkinson’s disease (PD), the most prevalent type of parkinsonism, is a progressive neurodegenerative condition marked by several non-motor and motor symptoms. PD is thought to have a complex aetiology that includes a combination of age, genetic predisposition, and environmental factors. Increased expression of α-synuclein (α-Syn) protein is central to the evolvement of neuropathology in this devastating disorder, but the potential of ribose-cysteine and levodopa in abating pathophysiologic changes in PD model is unknown. Crosses were set up between flies conditionally expressing a pathological variant of human α-Syn (UAS-α-Syn) and those expressing GAL4 in neurons (elav-GAL4) to generate offspring referred to as PD flies. Flies were randomly assigned to five groups ( n = 40) from the total population of flies, with each group having five replicates. Groups of PD flies were treated with either 500 mg/kg ribose-cysteine diet, 250 mg/kg levodopa diet, or a combination of the two compounds for 21 days, whereas the control group (w 1118 ) and the PD group were exposed to a diet without ribose-cysteine or levodopa. In addition to various biochemical and neurochemical assays, longevity, larval motility, and gravitaxis assays were carried out. Locomotive capability, lifespan, fecundity, antioxidant state, and neurotransmitter systems were all significantly ( p < 0.05) compromised by overexpression of α-Syn. However, flies treated both ribose cysteine and levodopa showed an overall marked improvement in motor functions, lifespan, fecundity, antioxidant status, and neurotransmitter system functions. In conclusion, ribose-cysteine and levodopa, both singly and in combination, potentiated a therapeutic effect on alpha-synuclein transgenic Drosophila melanogaster models of Parkinsonism.

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