d-Serine Intervention In The Medial Entorhinal Area Alters TLE-Related Pathology In CA1 Hippocampus Via The Temporoammonic Pathway

Beesley, Stephen; Sullenberger, Thomas; Ailani, Roshan; D’Orio, Cameron; Crockett, Mathew S.; Kumar, Sanjay S.

doi:10.1016/j.neuroscience.2020.10.025

Cited by 8 publications

(5 citation statements)

References 89 publications

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“…besides, D-serine contributes to maintaining cognitive abilities and functional plasticity of synapses (Ploux et al, 2020). Related studies have shown that intracranial injection of D-serine into the medial entorhinal area (MEA) in the TLE is beneficial to prevent neuronal loss and epileptogenesis by rescuing hippocampal CA1 neurons in the epileptic brain and reducing the number of astrocytes and microglia, thus alleviating the effect of neuroinflammation (Beesley et al, 2021). Therefore, D-serine might be a potential therapy target via regulating NMDAR in epilepsy, and more studies are needed in the future.…”

Section: D-serinementioning

confidence: 99%

Roles of N-Methyl-D-Aspartate Receptors (NMDARs) in Epilepsy

Chen

Liu

et al. 2022

Front. Mol. Neurosci.

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Epilepsy is one of the most common neurological disorders characterized by recurrent seizures. The mechanism of epilepsy remains unclear and previous studies suggest that N-methyl-D-aspartate receptors (NMDARs) play an important role in abnormal discharges, nerve conduction, neuron injury and inflammation, thereby they may participate in epileptogenesis. NMDARs belong to a family of ionotropic glutamate receptors that play essential roles in excitatory neurotransmission and synaptic plasticity in the mammalian CNS. Despite numerous studies focusing on the role of NMDAR in epilepsy, the relationship appeared to be elusive. In this article, we reviewed the regulation of NMDAR and possible mechanisms of NMDAR in epilepsy and in respect of onset, development, and treatment, trying to provide more evidence for future studies.

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Section: D-serinementioning

confidence: 99%

Roles of N-Methyl-D-Aspartate Receptors (NMDARs) in Epilepsy

Chen

Liu

et al. 2022

Front. Mol. Neurosci.

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“…It may have been through activating NMDAR [41]. D-Ser is also effective in preventing temporal lobe epileptogenesis (TLE) as well as reducing the severity of seizures [42,43]. The relevant investigation probed that intracranially injecting D-Ser mitigates neuronal loss in the medial entorhinal area (MEA), whereas neuronal loss is the hallmark of TLE [43].…”

Section: Parkinson's Disease and Seizurementioning

confidence: 99%

“…In addition, neuroinflammation was alleviated by D-Ser via reduction of astrocyte counts in the MEA, alerting the reactive status, and mitigating proliferation or infiltration of microglia to MEA [43]. Intense research revealed that the action of D-Ser in MEA may, through the temporoammonic pathway, alter the pathology of TLE in hippocampus [42].…”

Section: Parkinson's Disease and Seizurementioning

confidence: 99%

Promising Application of D-Amino Acids toward Clinical Therapy

Shi

Hussain

Zhao

2022

IJMS

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The versatile roles of D-amino acids (D-AAs) in foods, diseases, and organisms, etc., have been widely reported. They have been regarded, not only as biomarkers of diseases but also as regulators of the physiological function of organisms. Over the past few decades, increasing data has revealed that D-AAs have great potential in treating disease. D-AAs also showed overwhelming success in disengaging biofilm, which might provide promise to inhibit microbial infection. Moreover, it can effectively restrain the growth of cancer cells. Herein, we reviewed recent reports on the potential of D-AAs as therapeutic agents for treating neurological disease or tissue/organ injury, ameliorating reproduction function, preventing biofilm infection, and inhibiting cancer cell growth. Additionally, we also reviewed the potential application of D-AAs in drug modification, such as improving biostability and efficiency, which has a better effect on therapy or diagnosis.

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“…However, the exact role of D-serine is controversial. Some researchers proposed that D-serine prevents the loss of neurons in the medial entorhinal area (MEA) through inhibition of Ca 2+ -induced hyperexcitability by blocking highly calciumpermeable receptors and depletion of D-serine, as observed in MEA from epileptic animals (55). Other researchers argued that the interaction between D-serine and NMDARs can enhance the synaptic function and maintain long-term potentiation.…”

Section: D-serinementioning

confidence: 99%

Pathological Targets for Treating Temporal Lobe Epilepsy: Discoveries From Microscale to Macroscale

et al. 2022

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Temporal lobe epilepsy (TLE) is one of the most common and severe types of epilepsy, characterized by intractable, recurrent, and pharmacoresistant seizures. Histopathology of TLE is mostly investigated through observing hippocampal sclerosis (HS) in adults, which provides a robust means to analyze the related histopathological lesions. However, most pathological processes underlying the formation of these lesions remain elusive, as they are difficult to detect and observe. In recent years, significant efforts have been put in elucidating the pathophysiological pathways contributing to TLE epileptogenesis. In this review, we aimed to address the new and unrecognized neuropathological discoveries within the last 5 years, focusing on gene expression (miRNA and DNA methylation), neuronal peptides (neuropeptide Y), cellular metabolism (mitochondria and ion transport), cellular structure (microtubule and extracellular matrix), and tissue-level abnormalities (enlarged amygdala). Herein, we describe a range of biochemical mechanisms and their implication for epileptogenesis. Furthermore, we discuss their potential role as a target for TLE prevention and treatment. This review article summarizes the latest neuropathological discoveries at the molecular, cellular, and tissue levels involving both animal and patient studies, aiming to explore epileptogenesis and highlight new potential targets in the diagnosis and treatment of TLE.

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d-Serine Intervention In The Medial Entorhinal Area Alters TLE-Related Pathology In CA1 Hippocampus Via The Temporoammonic Pathway

Cited by 8 publications

References 89 publications

Roles of N-Methyl-D-Aspartate Receptors (NMDARs) in Epilepsy

Roles of N-Methyl-D-Aspartate Receptors (NMDARs) in Epilepsy

Promising Application of D-Amino Acids toward Clinical Therapy

Pathological Targets for Treating Temporal Lobe Epilepsy: Discoveries From Microscale to Macroscale

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