D2 dopamine receptor activation inhibits basal and forskolin-evoked acetylcholine release from dissociated striatal cholinergic interneurons

Login, Ivan S.

doi:10.1016/s0006-8993(96)01378-9

Cited by 5 publications

(2 citation statements)

References 25 publications

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“…Furthermore, present results indicate that prochlorperazine antinociception is dependent on central cholinergic activation. It should be noted that several D 2 antagonists, such as sulpiride, pipotiazine and domperidone, increase K + evoked ACh release [30], whereas the D 2 agonist quinpirole inhibit ACh efflux [31,32] from rat striatal preparations. The increase of the pain threshold induced by the investigated compound was prevented by the non-selective muscarinic antagonist atropine, the selective M 1 -antagonist pirenzepine, the ACh depletor HC-3 and an aODN to the M 1 receptor subtype.…”

Section: Discussionmentioning

confidence: 99%

Prochlorperazine induces central antinociception mediated by the muscarinic system

Ghelardini

Galeotti

Uslenghi

et al. 2004

Pharmacological Research

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The antinociceptive effect of the D 2 antagonist prochlorperazine was examined in the mouse hot-plate and abdominal constriction tests. Prochlorperazine (1-2 mg kg −1 s.c./i.p.) produced an increase of the pain threshold in the mouse hot-plate test. The antinociception produced by prochlorperazine was prevented by the D 2 selective agonist quinpirole, the unselective muscarinic antagonist atropine, the M 1 selective antagonist pirenzepine, and by the choline uptake inhibitor hemicholinium-3 hydrobromide (HC-3). Moreover, prochlorperazine antinociception was abolished by pretreatment with an aODN against the M 1 receptor subtype, administered at the dose of 2 nmol per single i.c.v. injection. By contrast the analgesic effect of prochlorperazine was not prevented by the opioid antagonist naloxone and the GABA B antagonist CGP-35348. Prochlorperazine also elicited a dose-dependent increase in ACh release from rat cerebral cortex. In the antinociceptive dose-range, prochlorperazine did not impair mouse performance evaluated by the rota-rod and hole-board tests. On the basis of the above data, it can be postulated that prochlorperazine exerted an antinociceptive effect mediated by a central cholinergic mechanism.

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Section: Discussionmentioning

confidence: 99%

Prochlorperazine induces central antinociception mediated by the muscarinic system

Ghelardini

Galeotti

Uslenghi

et al. 2004

Pharmacological Research

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“…We discussed above that D 1 -like receptors can also be coupled with Adcy1, and that Adcy5 or Adcy6 could be coupled with D 2 receptors, which are also found in cholinergic neurons in the striatum (Dawson et al, 1988;Alcantara et al, 2003). Furthermore, Adcys may also be involved in acetylcholine release from vesicles in these cells (Login, 1997).…”

Section: Striatum: Dopaminergic and Cholinergic Functionsmentioning

confidence: 96%

Neuroanatomical distribution and neurochemical characterization of cells expressing adenylyl cyclase isoforms in mouse and rat brain

Sanabra

Mengod

2011

Journal of Chemical Neuroanatomy

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Transmembrane adenylyl cyclases (Adcy) are involved in the regulation of multiple brain processes such as synaptic plasticity, learning and memory. They synthesize intracellular cyclic adenosine monophosphate (cAMP) following activation by G-protein coupled receptors. We examined the neuroanatomical distribution of the nine Adcy isoforms in rat and mouse brain by in situ hybridization, as well as their location in glutamatergic, GABAergic and cholinergic neurons in several mouse brain areas by double in situ hybridization. The Adcys are widely distributed throughout the brain in both rat and mouse, being especially abundant in cortex, hippocampus, thalamic nuclei, the olfactory system and the granular layer of the cerebellum. Double-labeling experiments showed that Adcy isoforms are differently expressed in glutamatergic, GABAergic and cholinergic neuronal cell populations. We report the neuroanatomical distribution of the nine known Adcy isoforms in rat and mouse brain and their cellular localization.

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Muscimol increases acetylcholine release by directly stimulating adult striatal cholinergic interneurons

Pal

Adams

et al. 1998

Brain Research

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D2 dopamine receptor activation inhibits basal and forskolin-evoked acetylcholine release from dissociated striatal cholinergic interneurons

Cited by 5 publications

References 25 publications

Prochlorperazine induces central antinociception mediated by the muscarinic system

Prochlorperazine induces central antinociception mediated by the muscarinic system

Neuroanatomical distribution and neurochemical characterization of cells expressing adenylyl cyclase isoforms in mouse and rat brain

Muscimol increases acetylcholine release by directly stimulating adult striatal cholinergic interneurons

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