D2-dopamine receptor blockade impairs motion detection in goldfish

Mora-Ferrer, Carlos; Gangluff, Volker

doi:10.1017/s0952523800171196

Cited by 17 publications

(14 citation statements)

References 44 publications

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“…Whether these are the same or different photoreceptor cells sharing the same spectral properties, however, is unknown. In goldfish, D1-dopamin receptor antagonists impaired red-green color discrimination ability, presumably by eliminating the contribution of the L-cones (47), whereas the D2-dopamin receptor antagonist impaired motion detection (48). In bees, photoreceptor types were recently reinvestigated (49,50), and eight (R1-R8) of nine photoreceptors in each ommatidium were characterized.…”

Section: Discussionmentioning

confidence: 99%

Motion vision is independent of color in Drosophila

Yamaguchi

Wolf

Desplan

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

167

141

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Whether motion vision uses color contrast is a controversial issue that has been investigated in several species, from insects to humans. We used Drosophila to answer this question, monitoring the optomotor response to moving color stimuli in WT and genetic variants. In the fly eye, a motion channel (outer photoreceptors R1-R6) and a color channel (inner photoreceptors R7 and R8) have been distinguished. With moving bars of alternating colors and high color contrast, a brightness ratio of the two colors can be found, at which the optomotor response is largely missing (point of equiluminance). Under these conditions, mutant flies lacking functional rhodopsin in R1-R6 cells do not respond at all. Furthermore, genetically eliminating the function of photoreceptors R7 and R8 neither alters the strength of the optomotor response nor shifts the point of equiluminance. We conclude that the color channel (R7/R8) does not contribute to motion detection as monitored by the optomotor response.apparent motion ͉ equiluminance ͉ motion detection ͉ opsin mutants ͉ R7/R8 system T he role of color vision in motion detection is still a matter of debate (for reviews, see refs. 1-3). In human vision, it was widely believed that color and motion are processed by parallel pathways (4). More recently, however, the complete segregation of motion detection and color vision came into question (for a review, see ref.2), because motion of the patterns of two equiluminant colors could still be detected. Thus, either the color vision system contributes to motion detection, or a residual difference in luminance could not have been eliminated experimentally (for a review, see ref. 1).In insects, it was first shown for the fleshfly Phormia that motion vision as monitored by the optomotor response depends on luminance contrast (5). Also in the honey bee, for which color vision is well established (6), the optomotor response has been shown to be largely insensitive to color contrast (7). The same was found for the landing response (8). Similar results were reported in vertebrate systems. In goldfish, which have a tetrachromatic color vision system (9), only L-cones (red) contribute to the optomotor response (10). In zebrafish larvae, both M-and L-cones seem to mediate motion responses, although only luminance information appears to be used (11). These studies clearly show that luminance contrast plays a major role in motion detection, as it does in humans. However, at the point of equiluminance, residual responses are frequently observed (5, 10), leaving the possibility that moving color contrast can, after all, elicit motion responses. So far, it was not possible to selectively switch off the color channel. Here, we used genetic intervention and the detailed knowledge of the Drosophila retina to address whether the color vision system contributes to motion detection.Drosophila has been shown to possess color vision (12, 13). As a prerequisite for this quality, an animal needs at least two types of photoreceptors differing in spectral sensitivity...

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Section: Discussionmentioning

confidence: 99%

Motion vision is independent of color in Drosophila

Yamaguchi

Wolf

Desplan

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

167

141

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“…In the guinea‐pig retina dopamine has recently been shown to be localized to amacrine cells type 1 and 2 ( Oh et al ., 1999 ). Some inherent functions of the retina involve the release of dopamine, e.g., dark‐light adaptation ( Djamgoz & Wagner, 1992 ) or motion detection ( Mora‐Ferrer & Gangluff, 2000 ).…”

Section: Introductionmentioning

confidence: 99%

Identification of the dopamine autoreceptor in the guinea‐pig retina as D₂ receptor using novel subtype‐selective antagonists

Weber

Schlicker

Sokoloff

et al. 2001

British J Pharmacology

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1 Dopamine release in the retina is subject to modulation via autoreceptors, which belong to the D 2 receptor family (encompassing the D 2 , D 3 and D 4 receptors). The aim of the present study was to determine the receptor subtype (D 2 vs D 3 ) involved in the inhibition of dopamine release in guineapig retinal discs, using established (haloperidol, (S)-nafadotride) and novel dopamine receptor antagonists .

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“…Dopamine action on postsynaptic targets was prevented by injection of the strong dopamine D 1 receptor antagonist SCH 23390 (Sigma) 2 nM, as in Huang et al. (2005) or the selective dopamine D 2 receptor antagonist sulpiride (Sigma), as in Lin and Yazulla (1994) and Mora-Ferrer and Gangluff (2000). Finally, the level of dopamine in the circuit was frozen by injection of the dopamine release and reuptake inhibitor vanoxerine (Santa Cruz Biotechnology) 2 μM, as in Schlicker et al.…”

Section: Methodsmentioning

confidence: 99%

Olfactory Stimulation Selectively Modulates the OFF Pathway in the Retina of Zebrafish

Esposti

Johnston

Rosa

et al. 2013

Neuron

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SummaryCross-modal regulation of visual performance by olfactory stimuli begins in the retina, where dopaminergic interneurons receive projections from the olfactory bulb. However, we do not understand how olfactory stimuli alter the processing of visual signals within the retina. We investigated this question by in vivo imaging activity in transgenic zebrafish expressing SyGCaMP2 in bipolar cell terminals and GCaMP3.5 in ganglion cells. The food-related amino acid methionine reduced the gain and increased sensitivity of responses to luminance and contrast transmitted through OFF bipolar cells but not ON. The effects of olfactory stimulus were blocked by inhibiting dopamine uptake and release. Activation of dopamine receptors increased the gain of synaptic transmission in vivo and potentiated synaptic calcium currents in isolated bipolar cells. These results indicate that olfactory stimuli alter the sensitivity of the retina through the dopaminergic regulation of presynaptic calcium channels that control the gain of synaptic transmission through OFF bipolar cells.

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D2-dopamine receptor blockade impairs motion detection in goldfish

Cited by 17 publications

References 44 publications

Motion vision is independent of color in Drosophila

Motion vision is independent of color in Drosophila

Identification of the dopamine autoreceptor in the guinea‐pig retina as D₂ receptor using novel subtype‐selective antagonists

Olfactory Stimulation Selectively Modulates the OFF Pathway in the Retina of Zebrafish

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D2-dopamine receptor blockade impairs motion detection in goldfish

Cited by 17 publications

References 44 publications

Motion vision is independent of color in Drosophila

Motion vision is independent of color in Drosophila

Identification of the dopamine autoreceptor in the guinea‐pig retina as D2 receptor using novel subtype‐selective antagonists

Olfactory Stimulation Selectively Modulates the OFF Pathway in the Retina of Zebrafish

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Identification of the dopamine autoreceptor in the guinea‐pig retina as D₂ receptor using novel subtype‐selective antagonists