D2 dopamine receptor-mediated mechanisms in the medial preoptic-anterior hypothalamus regulate affective defense behavior in the cat

Sweidan, Safwan; Edinger, Henry; Siegel, Allan

doi:10.1016/0006-8993(91)90608-x

Cited by 51 publications

(28 citation statements)

References 36 publications

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“…The effects of dopamine (DA) on aggression are also paradoxical. For example in mammals, while D1 and D2 dopamine receptor antagonists reduce aggression [14], D2 receptors in the medial preoptic area (mPOA) and anterior hypothalamus facilitate affective defense behaviour [15]. On the other hand, the mesocorticolimbic dopamine system has been shown to be involved in the preparation and execution of aggressive acts [16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Social modulation of brain monoamine levels in zebrafish

Teles

Dahlbom

Winberg

et al. 2013

Behavioural Brain Research

109

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h i g h l i g h t s• Zebrafish were exposed to different fighting experiences: winning, losing and mirror-fighting.• Winners show higher serotonergic and dopaminergic activity in the telencephalon.• Losers show higher serotonergic in the optic tectum.• No significant changes in monoamine activity were observed in mirror fighters.• Monoamines are differentially regulated by social interactions in different brain regions. a r t i c l e i n f o t r a c tIn social species animals tend to adjust their social behaviour according to the available social information in the group, in order to optimize and improve their one social status. This changing environment requires for rapid and transient behavioural changes that relies primarily on biochemical switching of existing neural networks. Monoamines and neuropeptides are the two major candidates to mediate these changes in brain states underlying socially behavioural flexibility. In the current study we used zebrafish (Danio rerio) males to study the effects of acute social interactions on rapid regional changes in brain levels of monoamines (serotonin and dopamine). A behavioural paradigm under which male zebrafish consistently express fighting behaviour was used to investigate the effects of different social experiences: winning the interaction, losing the interaction, or fighting an unsolved interaction (mirror image). We found that serotonergic activity is significantly higher in the telencephalon of winners and in the optic tectum of losers, and no significant changes were observed in mirror fighters suggesting that serotonergic activity is differentially regulated in different brain regions by social interactions. Dopaminergic activity it was also significantly higher in the telencephalon of winners which may be representative of social reward. Together our data suggests that acute social interactions elicit rapid and differential changes in serotonergic and dopaminergic activity across different brain regions.

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Section: Introductionmentioning

confidence: 99%

Social modulation of brain monoamine levels in zebrafish

Teles

Dahlbom

Winberg

et al. 2013

Behavioural Brain Research

109

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“…DA agonists also facilitate defensive aggression in cats (Maeda et al, 1985). This effect is mediated at least in part by D2 receptors within the medial POA and anterior hypothalamus (Sweidan et al, 1991). In the weakly electric fish, Apteronotus leptorhynchus, DA injections modulate agonistic electrocommunicative chirping (Maler and Ellis, 1987), and in the Arctic charr (Salvelinus alpinus) oral administrations of L-DOPA (a DA precursor) increase social dominance (Winberg and Nilsson, 1992).…”

Section: Introductionmentioning

confidence: 99%

Fos responses of dopamine neurons to sociosexual stimuli in male zebra finches

2006

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Dopamine (DA) is produced in numerous brain areas and influences a wide variety of social behaviors, but very few data are available to establish the socially-relevant response properties of most DA populations, which comprise eight cell groups numbered A8-A15. Anatomically, these DA populations are evolutionarily conserved, and all have been identified in both birds and mammals. We now report the Fos responses of tyrosine hydroxylase-immunoreactive (TH-ir; putatively dopaminergic) neurons in the A8-A15 cell groups of male zebra finches following exposure to a control condition or one of six different social stimuli: A heterospecific male, conspecific male, fighting in a mate competition paradigm (which includes both male and female stimuli), a courtship interaction without physical contact, a courtship interaction with physical contact but no mounting, and a courtship interaction with mounting. We found that the DA cell groups exhibit distinctive profiles of responsiveness to social stimuli. Fos induction in A8, A9, A10 and midbrain A11 neurons increased significantly in response to a variety of conspecific stimuli, but not heterospecific stimuli. In contrast, Fos induction in the preoptic A14 neurons was observed specifically in response to sexual interactions, and Fos induction in hypothalamic A11 neurons appears to primarily reflect the performance of courtship singing. Infundibular A12 neurons, which may be involved in stress-related processes, showed the highest level of TH+Fos colocalization in control subjects. This colocalization decreased in response to all conspecific stimuli except fighting, and did not decrease following exposure to a heterospecific male. Keywords dopamine; forebrain; aggression; sexual behavior; tyrosine hydroxylase; Fos Dopamine (DA) is known to influence a variety of social behaviors, particularly male sexual behavior, in multiple vertebrate groups (Warner et al., 1991;Pomerantz, 1992;Absil et al., 1994;Hull et al., 1995;Dominguez et al., 2001;Woolley et al., 2001;Melis et al., 2003;Charlier et al., 2005), and DA cells are distributed in homologous groups across the vertebrate classes (Bailhache and Balthazart, 1993;Bottjer, 1993;Gonzalez and Smeets, 1994;Reiner et al., 1994;Tillet, 1994;Appeltants et al., 2001;Adrio et al., 2002). This similarity across vertebrates is particularly clear when comparing mammals and birds, which each have dopaminergic neurons (immunopositive for tyrosine hydroxylase, TH, and immunonegative for dopamine β-hydroxylase) localized to eight populations of the basal forebrain and brainstem numbered A8 through A15 (Reiner et al., 1994;Tillet, 1994). However, it is largely unknown how these various DA populations respond to a broad range of social stimuli, so we have here examined DA neuronal responses to a variety of interactions with heterospecific and conspecific animals. Extensive data suggest that the release of DA into the preoptic area (POA) controls male sexual behavior. Administrations of the DA agonist apomorphine into the medial POA faci...

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“…In cats, apomorphine or D 2 receptor agonist microinjection into the medial preoptic-AH (mPO-AH) facilitates feline affective defense behavior elicited by electric stimulation of the VMH (Sweidan et al, 1991). Conversely, D 2 receptor antagonist infusion into the VMH blocks the proaggressive effect of both electrical stimulation and apomorphine potentiation (Sweidan et al, 1991). Likewise, D 2 receptor antagonist infusion into the AH of an aggressive Syrian hamster model dose dependently suppressed aggressive behavior (Schwartzer and Melloni, 2010).…”

Section: Mechanistic Insight On the Pa Establishment Of Perturbed Emomentioning

confidence: 99%

“…Patients suffering from schizophrenia, who display high levels of aggression, show an upregulation of the D 2 receptor in the striatum (Hirvonen et al, 2005), and haloperidol and risperidone are often used successfully to alleviate aggression in such patients (Volavka et al, 2004b). In cats, apomorphine or D 2 receptor agonist microinjection into the medial preoptic-AH (mPO-AH) facilitates feline affective defense behavior elicited by electric stimulation of the VMH (Sweidan et al, 1991). Conversely, D 2 receptor antagonist infusion into the VMH blocks the proaggressive effect of both electrical stimulation and apomorphine potentiation (Sweidan et al, 1991).…”

Section: Mechanistic Insight On the Pa Establishment Of Perturbed Emomentioning

confidence: 99%

“…Intriguingly, it overlaps with circuitry controlling fear, anxiety, and mating behavior at the neuroanatomical and even cellular level (Canteras and Graeff, 2014 Monoaminergic afferents target the central nodes of this aggression circuitry, and thereby confer modulatory and regulatory consequences on behavior (Figure 3). However, monoaminergic action in target regions depends on several factors ranging from the neuroanatomical connectivity map at the cellular level and the receptor complement present on Sweidan et al, 1991Schwartzer and Melloni, 2010Parsey et al, 2002Rosell et al, 2010Centenaro et al, 2008da Veiga et al, 2011 Local infusion: 5-HT1AR agonist Figure 3. Monoaminergic modulation of aggression circuitry.…”

Section: Mechanistic Insight On the Pa Establishment Of Perturbed Emomentioning

confidence: 99%

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Monoamine-Sensitive Developmental Periods Impacting Adult Emotional and Cognitive Behaviors

Suri

Teixeira

Cagliostro

et al. 2014

Neuropsychopharmacol

145

125

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Development passes through sensitive periods, during which plasticity allows for genetic and environmental factors to exert indelible influence on the maturation of the organism. In the context of central nervous system development, such sensitive periods shape the formation of neurocircuits that mediate, regulate, and control behavior. This general mechanism allows for development to be guided by both the genetic blueprint as well as the environmental context. While allowing for adaptation, such sensitive periods are also vulnerability windows during which external and internal factors can confer risk to disorders by derailing otherwise resilient developmental programs. Here we review developmental periods that are sensitive to monoamine signaling and impact adult behaviors of relevance to psychiatry. Specifically, we review (1) a serotonin-sensitive period that impacts sensory system development, (2) a serotonin-sensitive period that impacts cognition, anxiety-and depressionrelated behaviors, and (3) a dopamine-and serotonin-sensitive period affecting aggression, impulsivity and behavioral response to psychostimulants. We discuss preclinical data to provide mechanistic insight, as well as epidemiological and clinical data to point out translational relevance. The field of translational developmental neuroscience has progressed exponentially providing solid conceptual advances and unprecedented mechanistic insight. With such knowledge at hand and important methodological innovation ongoing, the field is poised for breakthroughs elucidating the developmental origins of neuropsychiatric disorders, and thus understanding pathophysiology. Such knowledge of sensitive periods that determine the developmental trajectory of complex behaviors is a necessary step towards improving prevention and treatment approaches for neuropsychiatric disorders.

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D2 dopamine receptor-mediated mechanisms in the medial preoptic-anterior hypothalamus regulate affective defense behavior in the cat

Cited by 51 publications

References 36 publications

Social modulation of brain monoamine levels in zebrafish

Social modulation of brain monoamine levels in zebrafish

Fos responses of dopamine neurons to sociosexual stimuli in male zebra finches

Monoamine-Sensitive Developmental Periods Impacting Adult Emotional and Cognitive Behaviors

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