D2: major subgenotype of hepatitis B virus in Russia and the Baltic region

Tallo, Tatjana; Tefanova, Valentina; Priimägi, Ljudmilla; Schmidt, Jelena; Katargina, Olga; Michailov, M. I.; Мукомолов, С. Л.; Magnius, Lars O.; Nordér, Helené

doi:10.1099/vir.0.83660-0

Cited by 71 publications

(46 citation statements)

References 29 publications

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“…The geographical distribution of the subgenotypes within genotype D (D1 to D7) was found to be less restricted than that of other HBV genotypes, although strains from the Middle East belong mainly to D1 (18), those from Russia and the Baltic region belong to D2 (28), strains from Serbia, South Africa, and Alaska belong to D3 (15), and those from Oceania and Somalia are specific for D4 (21). HBV D5 was reported from Japan and Eastern India (3), whereas D6 is most prevalent in Papua, Indonesia (16), and D7 is most prevalent in the Maghreb (Tunisia, Algeria, and Morocco) (17).…”

Section: Discussionmentioning

confidence: 89%

“…Twenty-one of these residues are found in the Pol ORF, and three each are found in the pre-S/S and X gene products. Of these 27 residues, 6 residues (V 30 and S 36 in the X ORF, R 28 and A 85 in the pre-S region, and L 269 and M 336 in the reverse transcriptase domain of the HBV polymerase) are unique to D5, i.e., are not shared or exhibited by the other D subgenotypes (D1 to D7).…”

Section: Analysis Of Hbv Open Reading Frames (Orfs) (I) Pre-s/s Orfmentioning

confidence: 99%

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Unique Hepatitis B Virus Subgenotype in a Primitive Tribal Community in Eastern India

et al. 2010

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Hepatitis B virus (HBV) strains isolated from members of the primitive Paharia ethnic community of Eastern India were studied to gain insight into the genetic diversity and evolution of the virus. The Paharia tribe has remained quite separate from the rest of the Indians and differs culturally, genetically, and linguistically from the mainstream East Indian population, whose HBV strains were previously characterized. Full-length HBV DNA was PCR amplified, cloned, and sequenced. Phylogenetic relationships between the tribal sequences and reference sequences from the mainstream population were assessed, and divergence times of subgenotypes of HBV genotype D were estimated. HBV was found in 2% of the Paharias participating in the study. A predominance of hepatitis B e antigen-negative infection (73%) was observed among the Paharias, and the genome sequences of the HBV strains exhibited relative homogeneity, with a very low prevalence of mutations. The novel feature of Paharia HBV was the exclusive presence of the D5 subgenotype, which was recently identified in Eastern India. Analysis of the four open reading frames (ORFs) of these tribal HBV D5 sequences and comparison with previously reported D1 to D7 sequences enabled the identification of 27 specific amino acid residues, including 6 unique ones, that could be considered D5 signatures. The estimated divergence times among subgenotypes D1 to D5 suggest that D5 was the first to diverge and hence is the most ancient of the D subgenotypes. The presence of a specific, ancient subgenotype of HBV within an ethnically primitive, endogamous population highlights the importance of studies of HBV genetics in well-separated human populations to understand viral transmission between communities and genome evolution.

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Section: Discussionmentioning

confidence: 89%

Section: Analysis Of Hbv Open Reading Frames (Orfs) (I) Pre-s/s Orfmentioning

confidence: 99%

Unique Hepatitis B Virus Subgenotype in a Primitive Tribal Community in Eastern India

et al. 2010

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“…Известно, что на большей части территории бывшего СССР и в странах Балтийского реги-она преобладает ВГВ субтипа D2, показаны субтипы А2 и D3 [20], в то время как для стран Средней Азии распределение субтипов ВГВ смещается в сторону преобладания субтипа D1.…”

Section: результаты и обсуждениеunclassified

Genetic Variants of Hepatitis B Virus in Primary Donors in Astana, Kazakhstan

Ostankova

Семенов²,

Burkitbayev³

et al. 2017

Russian Journal of Infection and Immunity

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Резюме. Широкая распространенность одного из гепатотропных вирусов, вируса гепатита В (ВГВ), остает-ся серьезнейшей проблемой мирового здравоохранения. Так как ВГВ передается при контакте с кровью или иными жидкостями организма инфицированного человека, безопасность крови является одним из главных вопросов здравоохранения в регионах с высоким уровнем распространенности вируса. Наблюдаемая в по-следние годы тенденция к смещению распространенности тех или иных генотипов ВГВ в различных гео-графических ареалах за счет иммиграции из регионов мира с высокой частотой встречаемости гепатотроп-ных вирусов, заставляет врачей и эпидемиологов обращать пристальное внимание на эпидемиологическую ситуацию в соседних странах. Целью нашей работы было изучение особенностей генетической структуры ВГВ у первичных доноров в г. Астана, Казахстан. Обследовано 30 образцов плазмы донорской крови с впер-вые выявленным вирусным гепатитом В (HBsAg+) из г. Астана. ДНК ВГВ была обнаружена в 27 образцах из представленных 30. На основании филогенетического анализа 27 изолятов показано, что в обследованной группе был выявлен преимущественно генотип D, являющийся наиболее распространенным генотипом ВГВ в Центральной Азии. При этом преобладал ВГВ субтипа D1 (85,2%) по сравнению с ВГВ субтипа D2 (3,7%) и субтипа D3 (7,4%), в одном образце был выявлен ВГВ генотипа А субтипа А1 (3,7%). Высокое сходство вы-явленных изолятов с ранее описанными в Иране, Судане, Монголии, Тунисе позволяет предположить много-численные независимые, возможно обоюдные, завозы вируса в страну, в том числе в ходе крупных миграци-онных волн, несмотря на наличие изолятов, свидетельствующих о независимой гомологичной эволюции ВГВ в регионе. Впервые обнаруженный на территории Казахстана ВГВ субтипа A1, нехарактерного для данного региона, а также субтипы D2 и D3, имеющие высокое сходство нуклеотидных последовательностей с ВГВ в РФ, свидетельствуют о случаях завоза вируса из других стран. Выявление особенностей распространения и роль «завозных» генотипов ВГВ в циркуляции вируса могут иметь существенное значение для регионов, где распространенность гепатотропных вирусов высока, а структура генома и пути их распространения недоста-точно изучены. 233-20-92 (служебн).

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“…Amino acid sequence analysis: Protein-coding regions of HBsAg (pre S1, Pre S2 and large S) gene were translated into amino acid sequences using the standard and universal genetic codes, respectively and was compared to surface antigen of other HBsAg strains which were retrieved from DDBJ/EMBL/GeneBank database (Tallo et al, 2008).…”

Section: Determination Of Hbsag Nucleotide Sequence and The Phylogenementioning

confidence: 99%

Identification of Novel D11 Hepatitis B Surface Antigen Subgenotype in Jeddah, Kingdom of Saudi Arabia

Hadad¹,

Alakilli²,

Rabah³

et al. 2015

Biotechnology

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A B S T R A C T Hepatitis B virus (HBV) infection remains to be a worldwide health problem. In Saudi Arabia, HBV is the most predominant type of hepatitis followed by hepatitis C and hepatitis A while little is known about the molecular epidemiology of the prevalence of HBV genotype/subgenotype particularly in Jeddah. Serum samples were collected from HBV chronic patients and subjected to HBsAg gene amplification. Sequencing and phylogenetic analysis of the entire HBsAg gene sequences revealed that 11 isolates belonged to HBV/D while 4 isolates were associated with HBV/C. Interestingly, HBV/D subgenotypes identified eight HBV/D present isolates belonged to HBV/D1 while three isolates showed a new cluster supporting by a branch with 99% bootstrap value and 4.3-5.8% nucleotide divergence over the entire HBsAg gene from other known subgenotypes D1 to D10, despite they were appearing more related to HBV/D5. The three strains of the new D subgenotype showed unique amino acid sequences consisting of Thr7non, 75Pro in the preS1 gene, 112Ile, 161Gly in the preS2 gene and 196Glu, 197Ala, 238Ser, 259Cys in the S gene. In addition to three amino acid residues in the S gene (373Ile, 374Ala and 381Thr) were specified S118S isolate. Subsequently, it have been verified that HBV/D1 is the most prevalent HBV subgenotype in Jeddah as well as we proposed a novel subgenotype designated HBV/D11. The identification of HBV/D11 novel subgenotypes in the present study suggested that further studies with a large number of subjects in previously examined and unexamined areas may lead to discovering new HBV strain genotypes and/or subgenotypes circulating in Saudi Arabia.

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D2: major subgenotype of hepatitis B virus in Russia and the Baltic region

Cited by 71 publications

References 29 publications

Unique Hepatitis B Virus Subgenotype in a Primitive Tribal Community in Eastern India

Unique Hepatitis B Virus Subgenotype in a Primitive Tribal Community in Eastern India

Genetic Variants of Hepatitis B Virus in Primary Donors in Astana, Kazakhstan

Identification of Novel D11 Hepatitis B Surface Antigen Subgenotype in Jeddah, Kingdom of Saudi Arabia

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