2016
DOI: 10.1136/jnnp-2016-314597.122
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D23 The effect of cognitive reserve on age of onset and executive functions in huntington’s disease and its neurobiological bases

Abstract: BackgroundAlthough age of onset of Huntington’s disease (HD) is mainly determined by the size of the CAG repeat expansion, other factors may play a role. One potential factor is Cognitive Reserve (CR), as it has been shown in other neurodegenerative disorders and ageing. ObjectiveThe objective of this study is to investigate the effect of CR on age of onset in HD and to examine the neural bases underlying the individual differences in executive function that could be due to the effects of CR in HD. MethodsThir… Show more

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