Work stress has been identified as a major factor affecting company's success because it affects the productivity and efficiency of the employees. In Malaysia, in light of industrial revolution 4.0 (IR4.0), work stress has been observed to continue happening within the construction industry even though they begin using advancement of technology to help ease employees related tasks. This study examines whether the factors suggested in the theory of Job Demand, Control and Support (JDCS) determine work stress of employees in the construction industry. A survey was carried out on a group of safety and health practitioners in the construction industry they play an essential role in enhancing efficiency on the wellbeing arrangements of the workplace. Statistical analyses carried out on the three variables, namely the, job demand, job control and job support determined work stress. The findings indicate the importance and usefulness of the JDCS theory in explaining why employees experience work stress. The findings imply the need of how IR4.0 could cope with the three determinants in their workplace; namely, to cope with their job demand as well to enable them to believe that they have all the control and support they need to perform their work without stress.