Da-Cheng-Qi Decoction (DCQD) protects against pancreatic damage in murine experimental acute pancreatitis (AP)

Huang, W.; Jin, T.; Javed, M.A.; Wen, L.; Nunes, Q.M.; Chvanov, M.; Tepikin, A.; Criddle, D.N.; Xia, Q.; Sutton, R.

doi:10.1016/j.pan.2012.12.173

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“…Da-Cheng-Qi Decoction (DCQD) is composed of Dahuang ( Radix et Rhizoma Rhei ), Houpu ( Magnolia officinalis REHD . ), Zhishi ( Fructus Aurantii Immaturus ), and Mangxiao ( Natrii Sulfas ) and has been widely used to treat AP for over 30 years in China [ 13 , 15 – 17 ]. Recent studies have shown that DCQD can promote gastrointestinal motility, reduce acute lung injury, and inhibit cytokine activity and inflammatory responses in AP [ 15 – 18 ].…”

Section: Introductionmentioning

confidence: 99%

“…), Zhishi ( Fructus Aurantii Immaturus ), and Mangxiao ( Natrii Sulfas ) and has been widely used to treat AP for over 30 years in China [ 13 , 15 – 17 ]. Recent studies have shown that DCQD can promote gastrointestinal motility, reduce acute lung injury, and inhibit cytokine activity and inflammatory responses in AP [ 15 – 18 ]. However, more detailed insights into the molecular mechanism of DCQD are hampered by difficulties in identifying which specific components of the complex mixture produce the observed therapeutic effects [ 19 – 21 ].…”

Section: Introductionmentioning

confidence: 99%

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Tissue Pharmacology of Da-Cheng-Qi Decoction in Experimental Acute Pancreatitis in Rats

Zhao

Zhang

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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Objectives. The Chinese herbal medicine Da-Cheng-Qi Decoction (DCQD) can ameliorate the severity of acute pancreatitis (AP). However, the potential pharmacological mechanism remains unclear. This study explored the potential effective components and the pharmacokinetic characteristics of DCQD in target tissue in experimental acute pancreatitis in rats. Methods. Acute pancreatitis-like symptoms were first induced in rats and then they were given different doses of DCQD (6 g/kg, 12 g/kg, and 24 g/kg body weight) orally. Tissue drug concentration, tissue pathological score, and inflammatory mediators in pancreas, intestine, and lung tissues of rats were examined after 24 hours, respectively. Results. Major components of DCQD could be found in target tissues and their concentrations increased in conjunction with the intake dose of DCQD. The high-dose compounds showed maximal effect on altering levels of anti-inflammatory (interleukin-4 and interleukin-10) and proinflammatory markers (tumor necrosis factor α and interleukin-6) and ameliorating the pathological damage in target tissues (P < 0.05). Conclusions. DCQD could alleviate pancreatic, intestinal, and lung injury by altering levels of inflammatory cytokines in AP rats with tissue distribution of its components.

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Section: Introductionmentioning

confidence: 99%