“…We searched in the human proteome the presence of NPx[Y/F] motifs and found 1823 potential motifs (S0) in 1584 proteins. From these, only 15 proteins (P0) were documented and experimentally tested to have functional unphosphorylated tyrosine-based motifs that interact with PTB-domains (Zhang, 1997; Eigenthaler et al, 1997; Trommsdorff et al, 1998; Dho et al, 1998; Homayouni et al, 1999; Su et al, 2002; Calderwood et al, 2003; Marzolo et al, 2003; Stolt et al, 2003; Zhang et al, 2007; Huang et al, 2009; Park et al, 2010; Barbagallo et al, 2011; Fuchigami et al, 2013). Among them, the NPx[Y/F] motifs of Amyloid-beta precursor protein (APP, UniProtID: P05067), Low-density lipoprotein receptor-related protein 8 (LRP8, UniProtID: Q14114), Krev interaction trapped protein 1 (KRIT1, UniProtID: O00522) have been crystallized with their respective PTB domains present in the X11, GULP1, Dab1, ICAP1 and CCM2 proteins (Stolt et al, 2003; Zhang et al, 2007; Liu and Boggon, 2013; Fisher et al, 2015; Chau et al, 2019).…”