2012
DOI: 10.1007/s11239-012-0747-1
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Dabigatran and left atrial appendage thrombus

Abstract: A 59-year-old white woman with previous history of arterial hypertension consulted because of palpitations. Atrial fibrillation of uncertain duration was diagnosed. She was not receiving anticoagulants. A trans-esophageal echocardiogram was performed, and a large left atrial appendage thrombus was detected. A strategy of rate control and anti-vitamin K treatment was started. On the subsequent days, we could not reach therapeutic INRs. Therefore, it was decided to stop warfarin and initiate dabigatran. We descr… Show more

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Cited by 59 publications
(43 citation statements)
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“…However, TEE detected LAA thrombus during heparin administration in our 3 cases. There have been few recent reports about the resolution of LAA thrombus in patients treated with NOACs [6,7]. In our cases, TEE showed disappearance of thrombi after 1-5 weeks of rivaroxaban treatment without recurrent stroke.…”
Section: Introductionmentioning
confidence: 43%
“…However, TEE detected LAA thrombus during heparin administration in our 3 cases. There have been few recent reports about the resolution of LAA thrombus in patients treated with NOACs [6,7]. In our cases, TEE showed disappearance of thrombi after 1-5 weeks of rivaroxaban treatment without recurrent stroke.…”
Section: Introductionmentioning
confidence: 43%
“…Thrombus can be treated with warfarin, [12,13] but dabigatran can be considered an alternative to warfarin therapy. Five previous cases of dabigatran administration resulting in resolution of thrombus have been reported [7,[14][15][16][17]. The reported doses of dabigatran ranged from 220 to 300 mg/day, and resolution was confirmed after 3 weeks or longer (Table 1).…”
Section: Discussionmentioning
confidence: 92%
“…W celu leczenia skrzeplin wewnątrzsercowych, najczęściej umiejscowionych w uszku lewego przedsionka (LAA), dotychczas stosowano heparynę lub antagonistów witaminy K (VKA) [5]. Niemniej jednak, ostatnio udokumentowano, że nowe doustne antykoagulanty (NOAC) odznaczają się co najmniej porównywalną z VKA skutecznością w rozpuszczaniu skrzeplin w LAA [6,7]. Na uwagę zasługuje fakt, że skrzepliny w LAA były obecne rzadziej u pacjentów leczonych NOAC niż u chorych w trakcie terapii VKA [8].…”
Section: Wstępunclassified
“…Mimo ugruntowanej pozycji NOAC w prewencji udarów niedokrwiennych mózgu związanych z migotaniem przedsionków oraz ich niedawno udokumentowanej przewagi nad VKA w zapobieganiu tworzenia się skrzeplin w LAA [8], mało jest danych potwierdzających właściwości trombolityczne NOAC względem uprzednio wytworzonej skrzepliny [6,7]. Na uwagę zasługuje praca Nagamoto i wsp.…”
Section: Dyskusjaunclassified