DAC-Tam therapy as a treatment of the progressive stage of melanoma in a patient on maintenance hemodialysis

Guidelines for treatment of renal injury during cancer chemotherapy 2016

“…In all case reports, aside from a report by Inozume et al stating that, “In order to maximize the effect of the key drug cisplatin, we elected to perform dialysis the day after cisplatin” [ 191 ], dialysis was initiated 30 minutes to 1 hour following the administration of cisplatin. Without allowing a certain interval following cisplatin administration, free Pt will be eliminated from the blood by dialysis before it can bind to plasma proteins, thus greatly reducing the antitumor effect.…”

“…Most cisplatin removed from the body is free Pt; the majority of cisplatin binds to tissue and proteins, thus remaining in the body even when dialysis is performed. A post-dialysis rebound results in a renewed increase in free Pt in blood [ 191 , 195 – 200 ]. In addition, as the volume of accumulated cisplatin increases, the rate of cisplatin removed by dialysis further decreases [ 198 , 201 ].…”

Pharmacokinetics of cisplatin in an esophageal cancer patient on hemodialysis who was treated with a full-dose cisplatin-fluorouracil regimen: A case report

“…This figure plots the 39 cases (of 83 reports retrieved in the first search) in which the presence or absence of adverse effects was recorded. [9][10][11][12][13][14][15][16][17][18][19][20][21]23,[26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42] The Wilcoxon signed-rank sum test was used for the analysis, and P values of <0.05 were considered statistically significant. Statistical analyses were conducted with the JMP Pro software program (version 13.0.0, SAS Institute Inc., NC).…”