Daidzein down-regulates ubiquitin-specific protease 19 expression through estrogen receptor β and increases skeletal muscle mass in young female mice

Ogawa, Mitsuhiro; Kitano, Takeshi; Kawata, Natsuha; Sugihira, Takashi; Kitakaze, Tomoya; Harada, Naoki; Yamaji, Ryoichi

doi:10.1016/j.jnutbio.2017.07.017

Cited by 34 publications

(23 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the limitations of myoblast transplantation are related to poor migration and differentiation. It is reported that daidzein, a flavonoid, promotes skeletal muscle regeneration [33]. In our study we find that silibinin promoted migration and differentiation of murine C2C12 myoblasts.…”

Section: Discussionsupporting

confidence: 67%

Natural flavonoid silibinin promotes the migration and myogenic differentiation of murine C2C12 myoblasts via modulation of ROS generation and down-regulation of estrogen receptor α expression

et al. 2020

View full text Add to dashboard Cite

Skeletal muscle regeneration is a complex process, involving the proliferation, migration, and differentiation of myoblasts. Recent studies suggest that some natural flavanones stimulate myogenesis. However, the effect of plant estrogen, silibinin, on the regulation of myoblast behaviors is unclarified. In this study, we investigated the effects of silibinin on immortalized murine myoblast C2C12 in the aspects of proliferation, migration, differentiation along with underlying mechanisms. The results show that silibinin at concentrations below 50 μM enhanced the migration and differentiation of C2C12 cells, but had no effect on cell proliferation. Silibinin significantly promoted the production of ROS, which appeared to play important roles in the migration and differentiation of the myoblasts. Interestingly, among ROS, the superoxide anion and hydroxyl radical were associated with the migration, whereas hydrogen peroxide contributed to the myogenic differentiation. We used ER agonist and antagonist to explore whether estrogen receptors (ERs), which are affected by silibinin treatment in the silibinin-enhanced C2C12 migration and differentiation. Migration was independent of ERs, whereas the differentiation was associated with decreased ERα activity. In summary, silibinin treatment increases ROS levels, leading to the promotion of migration and myogenic differentiation. Negative regulation ERα of differentiation but not of migration may suggest that ERα represses hydrogen peroxide generation. The effect of silibinin on myoblast migration and differentiation suggests that silibinin may have therapeutic benefits for muscle regeneration.

show abstract

Section: Discussionsupporting

confidence: 67%

Natural flavonoid silibinin promotes the migration and myogenic differentiation of murine C2C12 myoblasts via modulation of ROS generation and down-regulation of estrogen receptor α expression

et al. 2020

View full text Add to dashboard Cite

show abstract

“…In general, it appears that both of these processes are at least partially mediated by biological sex, as prior works have found mRNAs related to these processes are differentially expressed between males and females [78]. Specifically females overall tend to have lower basal ubiquitin-proteasome activity compared to males, which is thought to be partially mediated by estrogen signaling [79,80]. This lowered ubiquitin-proteasome activity appears to result in differential FOXO3a-Ubiquitin signaling during disuse atrophy, with females showing less FOXO3a content compared to males, yet greater ubiquitinated protein content [49].…”

Section: Sex Difference In Anabolic and Catabolic Factorsmentioning

confidence: 78%

“…Females tend to have less satellite cells [60,61], which may be partially mediated by testosterone-activation of ARs on the satellite cells [64][65][66]. Females also tend to have less basal ubiquitin-proteasome activity and greater autophagy activity compared to males [79][80][81][82]. Finally, females appear to have differential regulation of myostatin activity and subsequent alterations to muscle physiology [49,98].…”

Section: Sex Difference In Anabolic and Catabolic Factorsmentioning

confidence: 99%

Muscle metabolism and atrophy: let’s talk about sex

2019

View full text Add to dashboard Cite

Skeletal muscle health is a strong predictor of overall health and longevity. Pathologies affecting skeletal muscle such as cancer cachexia, intensive care unit treatment, muscular dystrophies, and others are associated with decreased quality of life and increased mortality. Recent research has begun to determine that these muscular pathologies appear to present and develop differently between males and females. However, to our knowledge, there has yet to be a comprehensive review on musculoskeletal differences between males and females and how these differences may contribute to sex differences in muscle pathologies. Herein, we present a review of the current literature on muscle phenotype and physiology between males and females and how these differences may contribute to differential responses to atrophic stimuli. In general, females appear to be more susceptible to disuse induced muscle wasting, yet protected from inflammation induced (such as cancer cachexia) muscle wasting compared to males. These differences may be due in part to differences in muscle protein turnover, satellite cell content and proliferation, hormonal interactions, and mitochondrial differences between males and females. However, more works specifically examining muscle pathologies in females are necessary to more fully understand the inherent sex-based differences in muscle pathologies between the sexes and how they may correspond to different clinical treatments.

show abstract

“…ISP also contains naturally occurring compounds including isoflavones and saponins, which have antioxidant, anti-inflammatory, immunomodulatory, anti-cancer, and cardioprotective properties. 40 , 41 It also contains branched chain amino acids (BCAA), which may have a positive effect on body weight regulation and muscle protein synthesis. 42 BCAAs are obtained from ISPs, accounting for approximately 35% of the amino acids necessary for skeletal muscle formation.…”

Section: Can Soy Foods Improve Body Composition?mentioning

confidence: 99%

Effects of Soy Foods in Postmenopausal Women: A Focus on Osteosarcopenia and Obesity

Tang

et al. 2020

Journal of Obesity & Metabolic Syndrome

View full text Add to dashboard Cite

Chronic diseases in postmenopausal women are caused by rapid changes in hormones and are accompanied by rapid changes in body composition (muscle, bone, and fat). In an aging society, the health of postmenopausal women is a social issue, and people' s interest in ingesting high-quality protein is increasing in order to maintain a healthy body composition. This review aims to summarize the efficacy of soy foods and their impact on body composition. The soy protein and isoflavones contained in soy foods can improve muscle and bone density quality and reduce body weight. It is considered a breakthrough in preventing osteosarcopenia and obesity that may occur after menopause.

show abstract

Daidzein down-regulates ubiquitin-specific protease 19 expression through estrogen receptor β and increases skeletal muscle mass in young female mice

Cited by 34 publications

References 38 publications

Natural flavonoid silibinin promotes the migration and myogenic differentiation of murine C2C12 myoblasts via modulation of ROS generation and down-regulation of estrogen receptor α expression

Natural flavonoid silibinin promotes the migration and myogenic differentiation of murine C2C12 myoblasts via modulation of ROS generation and down-regulation of estrogen receptor α expression

Muscle metabolism and atrophy: let’s talk about sex

Effects of Soy Foods in Postmenopausal Women: A Focus on Osteosarcopenia and Obesity

Contact Info

Product

Resources

About