Daidzein induces MCF-7 breast cancer cell apoptosis via the mitochondrial pathway

Abstract

Accordingly, daidzein could induce breast cancer cell apoptosis through the mitochondrial caspase-dependent cell death pathway.

Breast cancer: Small molecules targeting apoptosis, a prospective approach to safe scientific success

“…Recently, Jin et al (2010) trying to exploit phytoestrogen to induce apoptosis in MCF-7, they used Daidzein which belongs to the isoflavone family, which is the most commonly ingested and most intensely studied type of phytoestrogen, often found in nuts, fruits, soybeans, and soy-based products. In their studies Jin et al (2010) demonstrated that daidzein induces apoptosis through the generation of ROS that perturb mitochondrial function, leading to mitochondrial permeability, cytochrome c release, and caspase activation. They further reported the loss of the antiapoptotic mitochondrial Bcl-2 protein as partially responsible for the opening of the mitochondrial permeability transition pore.…”

“…The loss of caspase-3 expression as well as defaults in cytochrome c release from the mitochondria, which is required in most apoptotic pathways to activate caspase-3 through caspase-9 activation, are associated with multidrug resistance. Accordingly, expression of caspase-3 in the human MCF-7 breast tumor cell line (which is deficient for caspase-3) restores the apoptotic response to the topoisomerase II inhibitor, etoposide [50]. Caspase-3 was also involved in breast cancer cell apoptosis upon exposure to anthracyclines and cisplatin [27,51].…”

Effect of Silk Fibroin Hydrolysate on the Apoptosis of MCF-7 human Breast Cancer Cells

“…Downregulation of Bcl-2 protein induces cell death though disruption of mitochondrial membrane permeability and subsequent release of cytochrome c (Kroemer et al, 2007). Several studies have reported disruption of mitochondrial membrane permeability in MCF-7 cells (Kallio et al, 2005;Jin et al, 2010). After the release of cytochrome c from the mitochondria, the apoptosome (which contain cytochrome c, Apaf-1, AIF, and procaspase-9)…”

Cationic PEGylated liposomes incorporating an antimicrobial peptide tilapia hepcidin 2–3: an adjuvant of epirubicin to overcome multidrug resistance in cervical cancer cells

“…Fluorescent probes such as DiOC 6 can be used to measure the mitochondrial transmembrane potential change. 45 Treatments of HeLa cells with epirubicin and/or hepcidin 2-3 for 24 h demonstrated significant declines in ΔΨ m ( Figure 5A). PEGylated liposomal epirubicin and hepcidin 2-3 further diminished ΔΨ m .…”