Daidzeinin ovaryum iskemi reperfüzyonu hasarındaki koruyucu etkisi

Toktay, Erdem; Gürbüz, Muhammet Ali; BAL, Tuğba; ÖZGÜL, Özlem; Erbaş, Elif; Uğan, Rüstem Anıl; Selli, Jale

doi:10.17826/cumj.993250

Cited by 6 publications

(10 citation statements)

References 53 publications

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“…Although many beneficial biological properties of ASX have been demonstrated in experimental models [8,33], investigation of its ovoprotective effect has become popular in recent years [28]. Our histological findings were consistent with the results of previous studies demonstrating the ovarian protective effect of ASX [11,34,35].…”

Section: Discussionsupporting

confidence: 91%

Therapeutic Effect of Astaxanthin on 5-Fluorouracil-Induced Ovarian Damage in Rats

Ayazoglu Demir,

Mentese,

Livaoglu

et al. 2024

Bilecik Şeyh Edebali Üniversitesi Fen Bilimleri Dergisi

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Although astaxanthin (ASX) is one of the most studied antioxidant molecules, its curative effect against ovarian damage caused by 5-fluorouracil (5-FU) has not been demonstrated to date. It was therefore aimed to investigate whether ASX is therapeutic against 5-FU-induced ovotoxicity in this study. Rats were first exposed to 5-FU (100 mg/kg) and then treated ASX (250 μg/kg) for three days. Oxidative stress (OS), inflammation and apoptosis markers were determined using spectrophotometric methods. Ovarian tissues were also evaluated histologically. The levels of OS, inflammation and apoptosis biomarkers increased by 5-FU administration (p<0.05). Treatment with ASX significantly alleviated these markers (p<0.05). These findings reveal that ASX may exert an ovoprotective effect by reducing pro-inflammatory mediators and enhancing antioxidant status in ovarian tissue.

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Section: Discussionsupporting

confidence: 91%

Therapeutic Effect of Astaxanthin on 5-Fluorouracil-Induced Ovarian Damage in Rats

Ayazoglu Demir,

Mentese,

Livaoglu

et al. 2024

Bilecik Şeyh Edebali Üniversitesi Fen Bilimleri Dergisi

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“…S. Zhu et al found that astaxanthin decreased caspase 3 expression levels in LX-2 hepatic stellate cells (24). In ischemia reperfusion injury in rat ovaries, administration of ASX significantly decreased Caspase 3, IL-1 β, and IL-6 expressions, and could be used as treatment for that injury (25).…”

Section: Discussionmentioning

confidence: 99%

Astaxanthin effect on apoptotic biomarkers in methotrexate-induced liver injury

Hamdan

Kamal

Waheed

2022

AJPS

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Methotrexate is used in the treatment of cancer, psoriasis, rheumatoid arthritis and several other disorders. It has a hepatotoxic potential side effect. Patients who have no access to alternative medications face a serious challenge as a result. The current study aimed to assess the apoptotic potential of methotrexate on liver cells and evaluate the hepatoprotective activity of the potent antioxidant astaxanthin, by downregulation of apoptotic biomarkers caspase 9 and caspase 3. A model of methotrexate-induced liver toxicity was employed on male rats. Thirty-six rats were divided into six groups; a negative control group, methotrexate induction group given (20 mg/kg) on day 13, three groups pretreated with astaxanthin in ascending doses (50, 75 and 100 mg/kg) for 14 days before methotrexate, and a conventional therapy group pretreated with silymarin (200mg/kg). The use of methotrexate significantly increased liver tissue caspase 9 and caspase 3 compared to the negative control. On the other side, astaxanthin used in all three doses significantly normalized these biomarkers. This study revealed that since astaxanthin significantly decreased caspase 9 and caspase 3 that are involved in the apoptotic pathway, it could be used as pretreatment in patients treated with methotrexate to alleviate its hepatotoxicity.

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“…Liver tissues were designed according to the procedure in the direction of relevant literature (Toktay et al 2020).…”

Section: Histological Proceduresmentioning

confidence: 99%

Effects of gossypin on acetaminophen-induced hepatotoxicity in mice

Çınar,

Yayla,

Toktay

et al. 2024

Trakya University Journal of Natural Sciences

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Liver injury from paracetamol (acetaminophen) (APAP) is common worldwide. To prevent intoxication with a drug with high poisoning, treatment can be made possible with an easily accessible and harmless substance. This study aimed to investigate the hepatoprotective ef-fects of Gossypin (GOS) in mice exposed to an overdose of APAP -the possible mechanism of action. Specifically, serum [alanine aminotransferase (ALT), aspartate transaminase (AST), and hepatic biochemical parameters (glutathione (GSH), malondialdehyde (MDA) and super-oxide dismutase (SOD)] were evaluated. Protein and mRNA levels of inflammatory, apoptot-ic, and cytochrome factors, including TNF-α, IL-1β, IL-6, NF-kB, and CYP2E1, were ana-lyzed using real-time PCR. Pretreatment with GOS significantly reduced APAP-induced he-patic injury via oxidative stress. Along with potent antioxidant activity, GOS promoted APAP hepatic detoxification by regulating AST, ALT, GSH, MDA, and SOD activities and mRNA levels of the cytochrome CYP2E1 gene. The anti-inflammatory activity of GOS in-creases its production. TNF-α, IL-1β and IL-6, through possible NF-kB blockade, are also responsible for its hepatoprotective effect. Taken together, GOS has the potential to be devel-oped as a preventive agent to be administered to patients suffering from APAP overdose.

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Daidzeinin ovaryum iskemi reperfüzyonu hasarındaki koruyucu etkisi

Cited by 6 publications

References 53 publications

Therapeutic Effect of Astaxanthin on 5-Fluorouracil-Induced Ovarian Damage in Rats

Therapeutic Effect of Astaxanthin on 5-Fluorouracil-Induced Ovarian Damage in Rats

Astaxanthin effect on apoptotic biomarkers in methotrexate-induced liver injury

Effects of gossypin on acetaminophen-induced hepatotoxicity in mice

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