“…Women face gender-related barriers and more difficulty to quit: weight gain concerns; menstrual/hormonal cycles influencing withdrawal and metabolization of nicotine/NRT; greater likelihood of depression and mood variability; lack of social support; family work; and caregiver burden. These barriers require tailored behavior interventions 4 , 23 , 40 , 44 . Treatment programs should use a patient-centered approach, focusing on gender-specific barriers, individual concerns, and beliefs; consider the complexity of variables influencing smoking behavior in women; and include intensive multicomponent interventions, i.e., motivational interviewing, problem-solving skills strategies, and cognitive behavior therapy addressing smoking cues, negative mood, weight management, and social support.…”