Daily consumption of a synbiotic yogurt decreases energy intake but does not improve gastrointestinal transit time: a double-blind, randomized, crossover study in healthy adults

Abstract

ObjectiveProbiotic and synbiotic products are widely marketed to healthy individuals, although potential benefits for these individuals are rarely studied. This study investigated the effect of daily consumption of a synbiotic yogurt on gastrointestinal (GI) function in a sample of healthy adults.Subjects/MethodsIn a randomized crossover double-blind study, 65 healthy adults consumed 200 g/day of yogurt with (synbiotic) or without (control) added probiotics (Bifidobacterium lactis Bb12, Lactobacillus acidophilus La5, Lactobacillus casei CRL431) and 4 g inulin for two 15-day treatment periods, each preceded by a 6-week washout period. GI transit time (GTT), duration of colour (DOC), GI symptoms and dietary intake were assessed and analyzed using repeated measures ANOVA, including PRE-treatment GTT as a covariate. Participants were grouped as short GTT (STT, n = 50, ≤32.7 h) or long GTT (LTT, n = 15, >32.7 h) based on their PRE-treatment GTT assessment.ResultsPOST-treatment GTT and DOC were not different between synbiotic and control, and did not change from PRE-treatment, within the STT or LTT groups. There were no changes in GI symptom ratings, indicating that both yogurts were well tolerated. In STT, energy, fat and protein intakes were decreased from baseline with synbiotic (p = 0.055, p = 0.059 and p = 0.005, respectively) and dietary fibre intake was higher POST-treatment with synbiotic versus control (p = 0.0002). In LTT, decreases in energy and fat intakes with synbiotic were not significant (p = 0.14 and p = 0.18, respectively) and there were no differences in dietary fibre intake.ConclusionConsuming 200 g/day of synbiotic yogurt did not significantly alter GTT in healthy adults, but was well tolerated and helped to reduce overall energy intake.

Sensory Acceptance, Appetite Control and Gastrointestinal Tolerance of Yogurts Containing Coffee-Cascara Extract and Inulin

“…Similarly, previous studies showed no differences in the hunger ratings of healthy young adults between yogurts with or without 6 g of inulin in a one-time consumption basis [26]. Other studies in which inulin intake showed an effect on appetite control include two-weeks of repeated consumption of symbiotic yogurts containing 4 g of inulin, which reduced the reported energy intakes [27]; and, eight-day consumption of yogurts containing 6 g of inulin, which significantly lowered the "desire to eat" and "prospective food consumption" ratings [28]. There is no previous research on the effect of coffee-cascara on appetite modulation.…”

18F-FDG uptake in the colon is modulated by metformin but not associated with core body temperature and energy expenditure

“…The mean transit time of the colon was estimated at approximately 30 hours [12, 13]. Therefore, subjects had to ingest the activated core temperature pill twenty-four hours prior to the visits to assure that the pill was located in the colon at the time the measurements took place.…”

“…Core body temperature was measured using a VitalSense® Core temperature capsule, and data were analysed using Equivital TM Manager (Hidalgo Limited, Cambridge, United Kingdom) core temperature pill. The mean transit time of the colon was estimated at approximately 30 hours [ 12 , 13 ]. Therefore, subjects had to ingest the activated core temperature pill twenty-four hours prior to the visits to assure that the pill was located in the colon at the time the measurements took place.…”

Produção de bebida fermentada enriquecida com Ora-pro-nóbis (Pereskia aculeata)

“…Os lactobacilos são reconhecidos por sua atuação na promoção de saúde e manutenção equilibrada da microbiota intestinal na qual, pode diminuir os procesos putrefativos por reduzir o acúmulo de substâncias nocivas no trato gastrointestinal. A presença de níveis elevados de bacterias bífidas está relacionado com uma microbiota intestinal saudável em todas as fases de vida da espécie humana [27,28].…”