Daily consumption of green tea catechin delays memory regression in aged mice

Unno, Keiko; Takabayashi, Fumiyo; Yoshida, H.; Choba, Daisuke; Fukutomi, Rie; Kikunaga, Naomi; Kishido, Takahiro; Oku, Naoto; Hoshino, Minoru

doi:10.1007/s10522-006-9036-8

Cited by 131 publications

(100 citation statements)

References 39 publications

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“…[19][20][21][22][23] Also, as green tea catechins are known to promote antioxidative activity in the brain it was investigated whether these substances can prevent Ab-induced cognitive impairment. 24,25 Oral treatment with epigallocatechin gallate, the main polyphenolic constituent of green tea, decreased Ab levels and plaques in mice, suggesting an activation of the a-secretase proteolytic pathway preventing the generation of Ab plaques.…”

Section: Discussionmentioning

confidence: 99%

Neural effects of green tea extract on dorsolateral prefrontal cortex

et al. 2012

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BACKGROUND/OBJECTIVES: Green tea is being recognized as a beverage with potential benefits for human health and cognitive functions. In vivo studies provide preliminary evidence that green tea intake may have a positive role in improving effects on cognitive functions. We aimed to examine the neural effects of green tea extract on brain activation in humans. SUBJECTS/METHODS: Functional magnetic resonance imaging was recorded while 12 healthy volunteers performed a working memory task following administration of 250 or 500 ml of a milk whey based green tea containing soft drink or milk whey based soft drink without green tea as control in a double-blind, controlled repeated measures within-subject design with counterbalanced order of substance administration. A whole-brain analysis with a cluster-level threshold of Po0.001 (unadjusted) was followed by an a priori-defined region of interest (ROI) analysis of the dorsolateral prefrontal cortex (DLPFC) including a cluster-level threshold of Po0.05 and family-wise error (FWE) adjustment for multiple comparisons. RESULTS: Whole-brain analyses revealed no significant effects after correction for multiple comparisons (FWE Po0.05). Using a ROI approach, green tea extract increased activation in the DLPFC relative to a control condition (FWE Po0.001). This neural effect was related to green tea dosage. Green tea extract was not associated with any significant attenuation in regional activation relative to control condition. CONCLUSIONS: These data suggest that green tea extract may modulate brain activity in the DLPFC, a key area that mediates working memory processing in the human brain. Moreover, this is the first neuroimaging study implicating that functional neuroimaging methods provide a means of examining how green tea extract acts on the brain.

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Section: Discussionmentioning

confidence: 99%

Neural effects of green tea extract on dorsolateral prefrontal cortex

et al. 2012

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“…22) In addition, our previous data indicates that the consumption of green tea catechin (catechin), a potent antioxidant in green tea, suppressed brain dysfunction and DNA oxidative damage in aged SAMP10. [23][24][25] These data strongly suggest that chronic intake of other antioxidants in fruits and vegetables also play a role in reducing the risk of age-related brain dysfunction. In this study, we investigated the effect of chronic consumption of b-CRX and mandarin juice, which contains a similar amount of b-CRX, on brain function using SAMP10 mice.…”

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confidence: 89%

Beta-Cryptoxanthin, Plentiful in Japanese Mandarin Orange, Prevents Age-Related Cognitive Dysfunction and Oxidative Damage in Senescence-Accelerated Mouse Brain

Unno

Sugiura

Ogawa

et al. 2011

Biological & Pharmaceutical Bulletin

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The brain is highly susceptible to oxidative damage because it consumes a large amount of oxygen and generates many free radicals as normal products of cellular metabolism. [1][2][3] In addition, the brain contains diverse lipid components and fewer antioxidant enzymes than other organs. 4) Although the antioxidant defense system responds to an increase in the production of reactive oxygen species (ROS) or peroxide under normal conditions, it gives rise to oxidative stress in the brain if an imbalance occurs between the production of ROS and the cellular defense capability. Aging is an important risk factor of this imbalance. Accumulation of oxidative damage is the most probable cause of the decline in learning and memory with aging.5) Preventing the accumulation of ROS-causing oxidative damage might suppress cognitive dysfunction.Several studies have demonstrated that dietary antioxidants from fruits and vegetables prevent oxidative stress in the brain.6-10) Neuroprotective dietary compounds have an essential role in reducing aging of the brain.11,12) Beta-cryptoxanthin (b-CRX, (3R)-b,b-caroten-3-ol, Fig. 1) is the main precursor of vitamin A in citrus juices.13) This carotenoid is not fully cleaved in vitamin A in the gut and it is therefore recovered in human plasma.14) Recent clinical studies indicated that the frequent intake of citrus fruits increases plasma b-CRX concentrations and reported b-CRX to be a biomarker of mandarin consumption.15) The concentrations of carotenoids, tocopherols and retinols were investigated in an aged human brain.16) An age-related decline in retinol, total tocopherols, total xanthophylls (oxygenated carotenoids) and total carotenoids was observed in frontal but not in occipital lobes. The antioxidative activity of b-CRX has been reported to scavenge radicals, 17) and to suppress lipid peroxidation 18) and nitrogen oxide production.19) The important role of antioxidants in the brain is thus expected. In this study, we investigated the effect of consumption of b-CRX (Fig. 1) and Satsuma mandarin orange (mandarin, Citrus unshiu MARC.) juice on brain function because b-CRX is rich in mandarin, the most popular fruit in Japan.We investigated the effect of b-CRX and mandarin juice on the brain using senescence-prone mouse strain 10 (SAMP10), which is a useful model of brain aging with a short life span and declined learning ability in later life. 20,21) Moreover, the production of superoxide anion was higher in SAMP10 than in other mice with normal longevity and brain function. 22) In addition, our previous data indicates that the consumption of green tea catechin (catechin), a potent antioxidant in green tea, suppressed brain dysfunction and DNA oxidative damage in aged SAMP10. [23][24][25] These data strongly suggest that chronic intake of other antioxidants in fruits and vegetables also play a role in reducing the risk of age-related brain dysfunction. In this study, we investigated the effect of chronic consumption of b-CRX and mandarin juice, which contains a similar amount of ...

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“…The intake of 1% EtOH had anti-aging effects in SAMP lines. The SAMP lines are often used to evaluate the antiaging effects of anti-oxidant foods such as reduced coenzyme Q10 (57) and teas (58,59). Ethanol is metabolized by alcohol dehydrogenase and aldehyde dehydrogenase, microsomal ethanol oxidation system (MEOS), and catalase.…”

Section: Clostridium Subcluster Xivamentioning

confidence: 99%

Moderate-dose Regular Lifelong Alcohol Intake Changes the Intestinal Flora, Protects against Aging, and Keeps Spatial Memory in the Senescence-accelerated Mouse Prone 8 (SAMP8) Model

et al. 2016

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-Purpose: Heavy and long-term alcohol consumption increase the risk of alcohol-related diseases. Epidemiological studies show moderate drinking reduces the risk of mortality, cardiovascular diseases, and brain infarction in the J-shaped or U-shaped curve effect. However, why moderate drinkers may be healthy and non-drinkers may be ill in diverse populations remains controversial. Herein, we examined the relationship between moderate/lifelong alcohol intake and aging, especially aging-related cognitive functions in senescenceaccelerated mouse prone 8 (SAMP8) model. Methods: SAMP8 model (5-week-old, male, n = 36), a model of age-related cognitive deficit, were group-housed (n = 6/cage) and provided free access to water (water group, n = 18) or 1% ethanol (EtOH group, n = 18, intake started when mice were 9 weeks old). The object recognition test (ORT) and object location test (OLT) were used to evaluate cognitive functions. The intestinal flora at the age of 87 weeks was analyzed by terminal restriction fragment length polymorphism (T-RFLP). Results: The lifespan of the EtOH-group mice was about 4 weeks longer than that of the water-group mice. In the EtOH group, spatial recognition impairment, assessed by OLT, was observed later (age, 73 weeks) than that in the water group (age, 52 weeks). The spinal curvature and skin conditions progressed significantly slower in the EtOH group than in the water group. Moreover, diarrhea symptoms only appeared in the water group, at the age of 82 weeks. The T-RFLP analysis of the intestinal flora indicated higher Lactobacillales order and lower Clostridium cluster XI in the EtOH group than in the water group, although those were extremely high in some mice close to death in both groups. Water-group mice with diarrhea presented significantly higher Clostridium cluster XI than did those without diarrhea (P = 0.017). Conclusion: Moderate alcohol intake changes intestinal flora and positively affects aging of SAMP8 model.This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page.

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Daily consumption of green tea catechin delays memory regression in aged mice

Cited by 131 publications

References 39 publications

Neural effects of green tea extract on dorsolateral prefrontal cortex

Neural effects of green tea extract on dorsolateral prefrontal cortex

Beta-Cryptoxanthin, Plentiful in Japanese Mandarin Orange, Prevents Age-Related Cognitive Dysfunction and Oxidative Damage in Senescence-Accelerated Mouse Brain

Moderate-dose Regular Lifelong Alcohol Intake Changes the Intestinal Flora, Protects against Aging, and Keeps Spatial Memory in the Senescence-accelerated Mouse Prone 8 (SAMP8) Model

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