Daily cortisol, stress reactivity and psychotic experiences in individuals at above average genetic risk for psychosis

Collip, Dina; Nicolson, Nancy A.; Lardinois, M; Lataster, Tineke; Os, Jim van; Myin-Germeys, Inez

doi:10.1017/s0033291711000602

Cited by 160 publications

(161 citation statements)

References 51 publications

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“…5,13 Previous studies have found elevated emotional reactivity to minor stressors in individuals with psychotic disorder and increased familial or psychometric risk (ie, a high score of sub-clinical PE). [12][13][14][15][16] Similarly, a recent study reported elevated emotional reactivity in response to minor stressors in individuals with an at-risk mental state (ARMS). 17 Previous research further suggest some degree of specificity, for example, of elevated emotional reactivity to social but not event-related stress as a putative mechanism underlying the association between childhood trauma and psychosis.…”

Section: Introductionmentioning

confidence: 98%

“…[8][9][10][11][12] Recently, the interplay between affective disturbances and stressful contexts and experiences in daily life (including stressful events, activities, and social situations) that may be underlying the development of PE has received much attention. [12][13][14][15][16] It has been repeatedly suggested that emotional reactivity to such routine daily hassles and minor socioenvironmental stressors may be an important mechanism. 5,13 Previous studies have found elevated emotional reactivity to minor stressors in individuals with psychotic disorder and increased familial or psychometric risk (ie, a high score of sub-clinical PE).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Modeling the Interplay Between Psychological Processes and Adverse, Stressful Contexts and Experiences in Pathways to Psychosis: An Experience Sampling Study

Klippel

Myin-Germeys

Chavez-Baldini

et al. 2017

Schizophrenia Bulletin

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Several integrated models of psychosis have implicated adverse, stressful contexts and experiences, and affective and cognitive processes in the onset of psychosis. In these models, the effects of stress are posited to contribute to the development of psychotic experiences via pathways through affective disturbance, cognitive biases, and anomalous experiences. However, attempts to systematically test comprehensive models of these pathways remain sparse. Using the Experience Sampling Method in 51 individuals with first-episode psychosis (FEP), 46 individuals with an atrisk mental state (ARMS) for psychosis, and 53 controls, we investigated how stress, enhanced threat anticipation, and experiences of aberrant salience combine to increase the intensity of psychotic experiences. We fitted multilevel moderated mediation models to investigate indirect effects across these groups. We found that the effects of stress on psychotic experiences were mediated via pathways through affective disturbance in all 3 groups. The effect of stress on psychotic experiences was mediated by threat anticipation in FEP individuals and controls but not in ARMS individuals. There was only weak evidence of mediation via aberrant salience. However, aberrant salience retained a substantial direct effect on psychotic experiences, independently of stress, in all 3 groups. Our findings provide novel insights on the role of affective disturbance and threat anticipation in pathways through which stress impacts on the formation of psychotic experiences across different stages of early psychosis in daily life.

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Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Modeling the Interplay Between Psychological Processes and Adverse, Stressful Contexts and Experiences in Pathways to Psychosis: An Experience Sampling Study

Klippel

Myin-Germeys

Chavez-Baldini

et al. 2017

Schizophrenia Bulletin

View full text Add to dashboard Cite

show abstract

“…13,15 A number of studies have reported elevated emotional reactivity to minor stressful events, activities, and social situations in individuals with enduring psychosis and in those with higher familial or psychometric risk. [17][18][19][20][21] Two studies in individuals at ultra high-risk (UHR) of developing psychosis, 22,23 reported greater emotional reactivity to minor activity-related and social stress in this group. 24,25 Findings from the only study conducted to date in individuals with first-episode psychosis (FEP), 25 which allowed to minimize the impact of illness chronicity, 20,24 further suggests that elevated stress sensitivity is associated with an increased intensity of psychotic experiences in FEP individuals, UHR individuals and controls, and this association is greatest in FEP individuals.…”

Section: Ecological Interventionist Causal Models In Psychosis Putatimentioning

confidence: 99%

Ecological Interventionist Causal Models in Psychosis: Targeting Psychological Mechanisms in Daily Life

Reininghaus

Depp

Myin-Germeys

2015

SCHBUL

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Integrated models of psychotic disorders have posited a number of putative psychological mechanisms that may contribute to the development of psychotic symptoms, but it is only recently that a modest amount of experience sampling research has provided evidence on their role in daily life, outside the research laboratory. A number of methodological challenges remain in evaluating specificity of potential causal links between a given psychological mechanism and psychosis outcomes in a systematic fashion, capitalizing on longitudinal data to investigate temporal ordering. In this article, we argue for testing ecological interventionist causal models that draw on real world and real-time delivered, ecological momentary interventions for generating evidence on several causal criteria (association, time order, and direction/sole plausibility) under real-world conditions, while maximizing generalizability to social contexts and experiences in heterogeneous populations. Specifically, this approach tests whether ecological momentary interventions can (1) modify a putative mechanism and (2) produce changes in the mechanism that lead to sustainable changes in intended psychosis outcomes in individuals' daily lives. Future research using this approach will provide translational evidence on the active ingredients of mobile health and in-person interventions that promote sustained effectiveness of ecological momentary interventions and, thereby, contribute to ongoing efforts that seek to enhance effectiveness of psychological interventions under real-world conditions.

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“…We used data from six different studies 10,[26][27][28][29] (see table S1 in the supplementary materials for in-and exclusion criteria of these studies) that used a similar ESM protocol. Participants were classified either as (i) 'healthy' control individuals (i.e.…”

Section: Samplesmentioning

confidence: 99%

The Cascade of Stress: A Network Approach to Explore Differential Dynamics in Populations Varying in Risk for Psychosis

Klippel

Viechtbauer

Reininghaus

et al. 2017

Schizophrenia Bulletin

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Daily cortisol, stress reactivity and psychotic experiences in individuals at above average genetic risk for psychosis

Cited by 160 publications

References 51 publications

Modeling the Interplay Between Psychological Processes and Adverse, Stressful Contexts and Experiences in Pathways to Psychosis: An Experience Sampling Study

Modeling the Interplay Between Psychological Processes and Adverse, Stressful Contexts and Experiences in Pathways to Psychosis: An Experience Sampling Study

Ecological Interventionist Causal Models in Psychosis: Targeting Psychological Mechanisms in Daily Life

The Cascade of Stress: A Network Approach to Explore Differential Dynamics in Populations Varying in Risk for Psychosis

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