Daily dose of clindamycin versus standard divided doses in obstetrical and gynecological infections: a retrospective cohort study

Giugno, Claudia S.; Silva, Alice L.; Fuhrich, Daniele Geras; Rabaioli, Paola Stefania Bohrer; Gonçalves, Katia G; Sartor, Nicole C; Savaris, Ricardo Francalacci

doi:10.1177/0956462413487516

Cited by 3 publications

(1 citation statement)

References 18 publications

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“…Gastrointestinal disorders are the major complications of metronidazole use that occur during treatment and may lead to discontinuation of treatment (11). Clindamycin is the next antibiotic of choice for BV treatment and is associated with such complications as abdominal cramps, difficile colitis, nausea, vomiting, diarrhea, and elevated liver enzymes (12). Statistics related to the expected rate of cure with this drug suggest its low efficacy in practice (13).…”

Section: Introductionmentioning

confidence: 99%

Comparing the Therapeutic Effects of Garlic Tablet and Oral Metronidazole on Bacterial Vaginosis: A Randomized Controlled Clinical Trial

Mohammadzadeh¹,

Dolatian²,

Jorjani³

et al. 2014

Iran Red Crescent Med J

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Background:Bacterial vaginosis (BV) is one of the most common gynecological infections during reproductive age. Although metronidazole is one of the most effective medications recommended as the first-line treatment, it has various side effects. Because of the side effects and contraindications of some chemical medicines, using herbs has been investigated in treating BV.Objectives:The aim of this study was to compare the effect of garlic tablet (Garsin) and oral metronidazole in clinical treatment of the BV in women referred to Resalat Health Center, affiliated with Mazandaran University of Medical Sciences, in 2013.Patients and Methods:This randomized clinical trial was conducted on 120 married women aged 18 to 44 years who were diagnosed with BV by Amsel’s clinical criteria and Gram staining. Enrolled women were randomly allocated to two groups of 60 patients and were treated with either garlic tablet or oral metronidazole for seven days. Amsel’s criteria and Gram stain were assessed seven to ten days after beginning the treatment period and side effects were registered.Results:Amsel’s criteria were significantly decreased after treatment with garlic or metronidazole (70% and 48.3%, respectively; P < 0.001). Therapeutic effects of garlic on BV were similar to that of metronidazole (63.3% and 48.3%, respectively; P = 0.141). There were significant differences between the two treatment groups in terms of side effects; metronidazole was associated with more complications (P = 0.032).Conclusions:This study reveals that garlic could be a suitable alternative for metronidazole in treatment of BV in those interested in herbal medicines or those affected by side effects of metronidazole.

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Section: Introductionmentioning

confidence: 99%

Comparing the Therapeutic Effects of Garlic Tablet and Oral Metronidazole on Bacterial Vaginosis: A Randomized Controlled Clinical Trial

Mohammadzadeh¹,

Dolatian²,

Jorjani³

et al. 2014

Iran Red Crescent Med J

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Antibiotics for treating septic abortion

Udoh

Effa

Oduwole

et al. 2016

Cochrane Database of Systematic Reviews

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We found no strong evidence that intravenous clindamycin alone was better than penicillin plus chloramphenicol for treating women with septic abortion. Similarly, available evidence did not suggest that penicillin plus chloramphenicol was better than cephalothin plus kanamycin for the treatment of women with septic abortion. Tetracyline enzyme antibiotic appeared to be more effective than intravenous penicillin G in reducing the time to fever defervescence, but this evidence was provided by only one study at low risk of bias.There is a need for high-quality RCTs providing reliable evidence for treatments of septic abortion with antibiotics that are currently in use. The three included studies were carried out over 30 years ago. There is also a need to include institutions in low-resource settings, such as sub-Saharan Africa, Latin America and the Caribbean, and South Asia, with a high burden of abortion and health systems challenges.

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Research progress of hydrogels in the prevention of pelvic inflammatory disease

Xiao,

Ma,

et al. 2024

MedComm – Biomaterials and Applications

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Pelvic inflammatory disease (PID) is a critical global health concern with the potential to lead to adverse outcomes, including infertility and chronic pelvic pain. Since PID is often caused by ascending vaginal infections or urinary tract infections, understanding the treatment of both is critical to preventing PID. Meanwhile, the emergence of drug‐resistant and persistently infected strains poses a growing challenge. This review discusses current clinical treatments for the prevention of PID from the physiologic basis of PID, as well as summarizes the advantages and research progress of hydrogels in the prevention of PID. In contrast to conventional treatments, hydrogels serve as excellent vehicles for vaginal drug delivery, maintaining the presence of the drug at the target site and controlling its release. In the context of urinary tract infections (UTIs), hydrogels are employed primarily as coatings on catheters to prevent and treat catheter‐associated UTIs. Finally, this review summarizes the limitations of hydrogels in PID prevention and future directions for development with the aim of elucidating avenues for clinical treatment of PID and informing further research.

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Daily dose of clindamycin versus standard divided doses in obstetrical and gynecological infections: a retrospective cohort study

Cited by 3 publications

References 18 publications

Comparing the Therapeutic Effects of Garlic Tablet and Oral Metronidazole on Bacterial Vaginosis: A Randomized Controlled Clinical Trial

Comparing the Therapeutic Effects of Garlic Tablet and Oral Metronidazole on Bacterial Vaginosis: A Randomized Controlled Clinical Trial

Antibiotics for treating septic abortion

Research progress of hydrogels in the prevention of pelvic inflammatory disease

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