Daily functioning in glioma survivors: associations with cognitive function, psychological factors and quality of life

Dyk, Kathleen Van; Wall, Lucy; Heimberg, Brandon F; Choi, Justin; Raymond, Catalina; Wang, Chencai; Lai, Albert; Cloughesy, Tim; Ellingson, Benjamin M.; Nghiemphu, Phioanh L.

doi:10.2217/cns-2022-0002

Cited by 8 publications

References 47 publications

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Identification of health-related quality of life profiles among long-term survivors of primary central nervous system tumors

Stockdill,

Mendoza,

Armstrong

et al. 2023

J Neurooncol

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Purpose We aimed to identify health-related quality of life (HRQOL) latent classes among primary central nervous system tumor (PCNST) long-term survivors (LTS) and to evaluate differences between classes in survivor sociodemographic characteristics, clinical characteristics, and symptoms to guide the development of survivorship care programs tailored to unique class needs. Methods Data from 298 PCNST LTS reporting HRQOL on the EQ-5D-3L were analyzed using latent profile analysis. Correlations and independent group t-tests were performed to identify differences between identified HRQOL classes by sociodemographic, clinical characteristics, and symptoms. Results Sample mean age was 48 years, 54% were male, 82% Caucasian, 56% employed, 60% had a high-grade glioma, and 52% had a KPS ≥ 90. Two HRQOL classes, good (61%) and poor (39%), were identified. The good HRQOL class reported no problems with self-care and few problems with mobility or usual activities. Thirty-eight percent reported anxiety and depression and 21% pain. Over 94% of the poor HRQOL class had at least moderate problems with mobility and usual activities, and over 50% had pain, self-care issues, anxiety, and depression. Older age (φ = 0.21), unemployment (φ = 0.30), spine tumors (φ = 0.18), active treatment (φ = 0.20), tumor recurrence (φ = 0.28), and poorer KPS scores (φ = 0.61) were associated with membership in the poor HRQOL class. Conclusions In the poor PCNST LTS HRQOL class, an overwhelming majority faced significant physical challenges, and the good HRQOL class experienced mood-related disturbance but limited physical challenges. These HRQOL profiles can be used to guide survivorship programs and tailored interventions.

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