Daily living activities, exercise capacity, cognition, and balance in COPD patients with and without frailty

Kagiali, Sezen; İnce, Deni̇z İnal; Çakmak, Aslıhan; Çalık-Kütükçü, Ebru; Sağlam, Melda; Vardar-Yağlı, Naciye; Tekerlek, Haluk; Sonbahar-Ulu, Hazal; Arıkan, Hülya; Bozdemir-Özel, Cemile; Çöplü, Lütfi

doi:10.1007/s11845-021-02654-8

Cited by 11 publications

(13 citation statements)

References 37 publications

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“…FFP is still a widely accepted reference model [ 43 ]. This was further confirmed in 50% of the included studies where the FFP was used as the measurement [ 10 , 11 , 13 , 23 – 25 , 29 – 32 ]. However, the participants in the above studies focused on the community-based population and stable outpatients with COPD.…”

Section: Discussionmentioning

confidence: 65%

“…3 B]. Similarly, the meta-analysis of mMRC grade from nine studies [ 11 , 13 , 23 – 26 , 29 , 33 , 35 ] showed that having frailty was associated with higher mMRC grade [mean difference 0.93(95%CI 0.85 to 1.02; I 2 = 0.00%, Fig. 3 C].…”

Section: Resultsmentioning

confidence: 91%

“…The details of the quality assessment are shown in Additional Tables 2 , 3 and 4 . The quality assessment showed that of the 20 studies included, one article [ 22 ] was of low quality and 6 articles [ 23 – 28 ] were medium quality; the remaining articles were all rated as high quality.…”

Section: Resultsmentioning

confidence: 99%

“…For frailty evaluation, 10 studies [ 10 , 11 , 13 , 23 – 25 , 29 – 32 ](50%) used the criteria of FFP; frailty was also measured by using other measurements, such as the Timed “Up and Go”(TUG) test [ 22 ](1, 5%) the comprehensive geriatric assessment (CGA) [ 26 ](1, 5%), frailty index [ 26 , 30 , 33 ](3, 15%), Frailty Staging System [ 34 ](1,5%), the Kihon Checklist [ 27 , 28 ](2,10%), FRAIL Scale [ 35 ](1,5%), the Reported Edmonton Frailty Scale(REFS) [ 14 ](1,5%) and HFRS [ 12 ](1,5%). One study used six criteria including weight loss, physical activity, mobility, hearing, strength for physical frailty, and anxiety/depression to assess frailty [ 36 ].…”

Section: Resultsmentioning

confidence: 99%

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Prevalence and clinical impact of frailty in COPD: a systematic review and meta-analysis

2023

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Background Frailty has been increasingly identified as a risk factor of adverse outcomes in chronic obstructive pulmonary disease (COPD). The prevalence and impact of frailty on health outcomes in people with COPD require clarification. Methods PubMed, Embase, The Cochrane Library and Web of Science (January 1, 2002, to July 1, 2022) were comprehensively searched to identify studies related to frailty and COPD. Comparisons were made between people who did and did not have frailty for pulmonary function, dyspnea severity, 6-minute walking distance, activities of daily life, and mortality. Results Twenty studies (9 cross-sectional, 10 cohort studies,1 clinical trial) from Europe (9), Asia (6), and North and South America (4), Oceania (1) involving 11, 620 participants were included. The prevalence of frailty was 32.07% (95% confidence interval (CI) 26.64–37.49) with a range of 6.43–71.70% based on the frailty tool used. People with frailty had lower predicted forced expiratory volume in the first second (mean difference − 5.06%; 95%CI -6.70 to -3.42%), shorter 6-minute walking distance (mean difference − 90.23 m; 95%CI -124.70 to -55.76), poorer activities of daily life (standardized mean difference − 0.99; 95%CI -1.35 to -0.62), higher CAT(COPD Assessment Test) score(mean difference 6.2; 95%CI 4.43 to 7.96) and mMRC (modified Medical Research Council) grade (mean difference 0.93; 95%CI 0.85 to 1.02) compared with those who did not (P < 0.001 for all). Meta-analysis showed that frailty was associated with an increased risk of long-term all-cause mortality (HR 1.68; 95% CI 1.37–2.05; I2 = 0%, P < 0.001). Conclusion Frailty is prevalent in people with COPD and linked with negative clinical outcomes including pulmonary function, dyspnea severity, exercise capacity, quality of life and mortality.

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Section: Discussionmentioning

confidence: 65%

Section: Resultsmentioning

confidence: 91%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Prevalence and clinical impact of frailty in COPD: a systematic review and meta-analysis

2023

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“…The incidence of COPD in people over 60 has reached 27% 1 , 2 and has become the world’s third leading cause of death. 3 The risk of frailty in COPD patients is twice as high as in non-COPD patients due to aging, smoking, neuroendocrine dysfunction, immune system dysfunction, and chronic inflammation, 4 , 5 and has a proportion of 9–28% in COPD patients. 6 Additionally, COPD patients with frailty usually have a higher risk of adverse events, such as acute exacerbation, readmission, falls, disability, and even death.…”

Section: Introductionmentioning

confidence: 99%

Risk Factors of Readmission Within 90 Days for Chronic Obstructive Pulmonary Disease Patients with Frailty and Construction of an Early Warning Model

Ma¹,

Zeng²,

Zhou³

et al. 2023

COPD

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Objective This study aimed to explore the risk factors for readmission within 90 d in Chronic Obstructive Pulmonary Disease (COPD) patients with frailty and construct a clinical warning model. Methods COPD patients with frailty hospitalized in the Department of Respiratory and Critical Care Medicine of Yixing Hospital, Affiliated to Jiangsu University, were retrospectively collected from January 1, 2020, to June 30, 2022. Patients were divided into readmission and control groups according to readmission within 90 d. The clinical data of the two groups were evaluated by univariate and multivariate logistic regression analyses to identify readmission risk factors within 90 d in COPD patients with frailty. Then, a risk quantitative early warning model was constructed. Finally, the model’s prediction efficiency was evaluated, and external verification was carried out. Results The multivariate logistic regression analysis showed that BMI, number of hospitalizations in the past year ≥ 2, CCI, REFS, and 4MGS were independent risk factors for readmission within 90 d in COPD patients with frailty. The early warning model for these patients was established as follows: Logit (p) = −1.896 + (−0.166 × BMI) + (0.969 × number of hospitalizations in the past year ≥ 2) + (0.265 × CCI) + (0.405 × REFS) + (−3.209 × 4MGS), and presented an area under the ROC curve (AUC) of 0.744 [95% CI: 0.687–0.801]. The AUC of the external validation cohort was 0.737 (95% CI: 0.648–0.826), and the AUC of the LACE warning model was 0.657 (95% CI:0.552–0.762). Conclusion The BMI, number of hospitalizations in the past year ≥ 2, CCI, REFS, and 4MGS were independent risk factors for readmission within 90 d in COPD patients with frailty. The early warning model presented a moderate predictive value for assessing the risk of readmission within 90 d in these patients.

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Frailty and its influence on mortality and morbidity in COPD: A Systematic Review and Meta-Analysis

Verduri,

Carter,

Laraman

et al. 2023

Intern Emerg Med

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Frailty increases vulnerability to adverse outcomes. Long-term conditions increase the risk of frailty. We searched PubMed, Web of Science, The Cochrane Library, EMBASE from inception to March 2022. Quality assessment was conducted using the NOS. Data was analysed in a pooled a random-effects meta-analysis. Our primary outcome was the impact of frailty on mortality in adults with Chronic Obstructive Pulmonary Disease (COPD) diagnosis according to the guidelines. Secondary outcomes were: frailty and association with readmissions, hospitalisations, exacerbation rates, and prevalence of frailty in COPD. We identified 25 studies, with 5882 participants. The median prevalence of frailty was 47% (IQR, 39.3–66.3%, range 6.4–72%). There was an association between COPD patients living with frailty and increased risk of mortality versus COPD patients without frailty (pooled OR, 4.21 (95% CI 2.99–5.93, I2 55%). A descriptive analysis of relationship between frailty and hospital readmission and all cause hospitalization showed positive associations. The relationship between frailty and the risk of exacerbation showed a pooled OR, 1.45 (95% CI 0.37–5.70, I2 80%). Frailty is significantly associated with higher mortality risk in COPD. Frailty is common in patients with COPD and its measurement should be considered in clinical practice to better characterise COPD.

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Daily living activities, exercise capacity, cognition, and balance in COPD patients with and without frailty

Cited by 11 publications

References 37 publications

Prevalence and clinical impact of frailty in COPD: a systematic review and meta-analysis

Prevalence and clinical impact of frailty in COPD: a systematic review and meta-analysis

Risk Factors of Readmission Within 90 Days for Chronic Obstructive Pulmonary Disease Patients with Frailty and Construction of an Early Warning Model

Frailty and its influence on mortality and morbidity in COPD: A Systematic Review and Meta-Analysis

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