Daily memantine treatment blunts hedonic response to sucrose in rats

Galistu, Adriana; D’Aquila, Paolo S.

doi:10.1007/s00213-019-05348-3

Cited by 4 publications

(19 citation statements)

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“…1-h before the preceding session in the experiment reported in the present paper—or immediately after the preceding session in the previously published study. Therefore, only the effects observed in the “before testing” sessions of this study—and in the “before testing” group of the previously published study [ 30 ]–can be accounted for by NMDA receptor blockade (or by activity at other receptors) during testing sessions.…”

Section: Introductionmentioning

confidence: 86%

“…A similar protocol was adopted in a recent study investigating the effects of imipramine on ingestion [ 29 ]. Since the differences observed between the “before testing” and the “after testing” sessions could not be easily accounted for by the presumed different brain drug levels at testing time, to tease apart the effects related to the different administration time, a second experiment was performed adopting a between-subject design, investigating the effect of memantine daily treatment for seven days with the drug administered either 1-h before or immediately after the testing sessions in two separate groups of subjects [ 30 ].…”

Section: Introductionmentioning

confidence: 99%

“…“Before testing” and “after testing” sessions of the experiment reported in the present paper might be meaningfully compared to the testing sessions of the “before testing” and of the “after testing” groups, respectively, of the already published experiment [ 30 ], as far as the presumed memantine brain levels at testing time are concerned. As reported in a previous study, the brain maximal concentration (C max ) of memantine in rats following intra-peritoneal injection was reached after 68.5 ± 3.4 minutes (T max ), with a half-life of 2.8 ± 0.5 hours [ 31 ].…”

Section: Introductionmentioning

confidence: 99%

“…In the above cited study [ 30 ], daily treatment before testing sessions for seven days reduced ingestion due to reduced burst size, thus suggesting a blunted hedonic/reward evaluation response, an effect likely due to NMDA receptor blockade occurring during testing time. Notably, this effect was accompanied to reduced intra-burst lick rate, which leaves open the possibility of a role for motor impairment in the observed effect.…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, daily post-session administration for seven days in a separate group of subjects induced a dramatic decrease of the activation of licking behaviour, indicated by reduced burst number. As a possible explanation for this response pattern, we hypothesised the development of a memory-related effect, such as conditioned taste aversion (CTA) [ 30 ] (see also [ 32 – 34 ]).…”

Section: Introductionmentioning

confidence: 99%

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Memantine effects on ingestion microstructure and the effect of administration time: A within-subject study

Galistu

D’Aquila

2020

PLoS ONE

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In a between-subject comparison of two memantine administration schedules we observed that treatment with the NMDA receptor antagonist memantine before testing sessions reduced ingestion of a 10% sucrose solution in rats, due to reduced licking burst size, thus suggesting a blunted hedonic response. Conversely, daily post-session administration reduced burst number, indicating a reduced level of behavioural activation, likely due to the development of conditioned taste aversion (CTA). In this study, the effect of pre-session and post-session memantine administration was investigated within-subjects. Memantine was administered in daily intraperitoneal injections for 13 days, on alternate days, either 1-h before–“before testing” sessions—or immediately after a 30-min session–“after testing” sessions. The effects on the microstructure of licking for a 10% sucrose solution were examined in the course of treatment and for 21 days after treatment discontinuation. The results show reduced burst size in the “before testing” sessions, without effects on the intra-burst lick rate, an index of motoric effects. Moreover, burst number was reduced since the third session of both administration conditions until the end of treatment. Interestingly, the effect of memantine of reducing the activation of ingestive behaviour was less pronounced in this study with respect to that observed with the previous study post-session administration schedule, in spite of the longer treatment. This apparent paradox might be explained if one considers these effects as instances of a memory-related effect, such as the development of CTA. In the framework of this hypothesis, the “before testing” sessions, not being followed by memantine administration, can be considered as extinction sessions performed every other day. Moreover, the animals treated with memantine at the highest dose failed to recover to pre-treatment ingestion levels 21 days after treatment discontinuation, while the animals treated after testing sessions in the previously published study showed a complete recovery well before the 15 th day test. Within the same interpretative framework, this might depend by the reduced number and frequency of the extinction trials—i.e. the number of the sessions run after treatment discontinuation—in the present study. These results provide further support to the conclusion that memantine administration before sessions reduce burst size, an effect which is likely due to blockade of NMDA receptors occurring during behavioural testing. The observation that this effect can be obtained even in absence of a reduced intra-burst lick rate, which rules out the involvement of motor impairment, provides an important piece of evidence in support to the interpretation of this effect as a blunted hedonic response. Moreover, these results provide further evidence that burst number reduction is due to a memory-related effect induced by memantine administration after sessions.

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Section: Introductionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Memantine effects on ingestion microstructure and the effect of administration time: A within-subject study

Galistu

D’Aquila

2020

PLoS ONE

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Dopamine, activation of ingestion and evaluation of response efficacy: a focus on the within-session time-course of licking burst number

D’Aquila

2024

Psychopharmacology

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Rationale Evidence on the effect of dopamine D1-like and D2-like receptor antagonists on licking microstructure and the forced swimming response led us to suggest that (i) dopamine on D1-like receptors plays a role in activating reward-directed responses and (ii) the level of response activation is reboosted based on a process of evaluation of response efficacy requiring dopamine on D2-like receptors. A main piece of evidence in support of this hypothesis is the observation that the dopamine D2-like receptor antagonist raclopride induces a within-session decrement of burst number occurring after the contact with the reward. The few published studies with a detailed analysis of the time-course of this measure were conducted in our laboratory. Objectives The aim of this review is to recapitulate and discuss the evidence in support of the analysis of the within-session burst number as a behavioural substrate for the study of the mechanisms governing ingestion, behavioural activation and the related evaluation processes, and its relevance in the analysis of drug effects on ingestion. Conclusions The evidence gathered so far suggests that the analysis of the within-session time-course of burst number provides an important behavioural substrate for the study of the mechanisms governing ingestion, behavioural activation and the related evaluation processes, and might provide decisive evidence in the analysis of the effects of drugs on ingestion. However, further evidence from independent sources is necessary to validate the use and the proposed interpretation of this measure.

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Microstructure analysis of the effects of the cannabinoid agents HU-210 and rimonabant in rats licking for sucrose

D’Aquila

2020

European Journal of Pharmacology

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Daily memantine treatment blunts hedonic response to sucrose in rats

Cited by 4 publications

References 52 publications

Memantine effects on ingestion microstructure and the effect of administration time: A within-subject study

Memantine effects on ingestion microstructure and the effect of administration time: A within-subject study

Dopamine, activation of ingestion and evaluation of response efficacy: a focus on the within-session time-course of licking burst number

Microstructure analysis of the effects of the cannabinoid agents HU-210 and rimonabant in rats licking for sucrose

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