Daily, monthly and seasonal variation in PSA levels and the association with weather parameters

Connolly, David; Leeuwen, Pim J. van; Bailie, John; Murray, Liam; Keane, Patrick F.; Gavin, Anna

doi:10.1038/pcan.2010.37

Cited by 7 publications

(3 citation statements)

References 20 publications

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“…Seasonal variations in PSA levels were found to be apparent in another study performed by Connolly et al (12) although age-adjusted PSA levels were deprived of the seasonal effect. The season of spring seemed to increase total PSA, which was not meanwhile correlated with daily, weekly or monthly hours of sunshine, rainfall or mean temperature in the study.…”

Section: Discussionmentioning

confidence: 84%

Effect of Temperature and Humidity on Serum Prostate Specific Antigen Levels in Asymptomatic Male Population

Eren¹,

Özveri²,

Coşgun³

2016

jus

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ÖZ AmaçProstat spesifik antijenin (PSA) prostat kanseri tanısındaki hassasiyetini arttırmak amacıyla PSA düzeylerini etkileyebilecek faktörler literatürde araştırılmaktadır. Bu çalışmada, bireylerin PSA değerleri üzerinde sıcaklık ve nem gibi iklimsel parametrelerin olası etkisi araştırılmıştır. Gereç ve Yöntem ObjectiveTo determine the possible effect of climate parameters on prostate specific anigen (PSA) levels. Materials and MethodsAmong 2.150 males, 757 individuals participating in a general checkup service at our hospital group in the past one year were enrolled in this study. The mean age was 48.52 and all the individuals underwent PSA screening tests, abdominal ultrasonography examinations including prostatic evaluation, and urine examinations including microscopic evaluation. The data on climate parameters including daily minimum and maximum temperatures and their average values as well as daily moisture levels were obtained from the records of the Turkish State Meteorological Service, including 2 meteorological stations existed in the Anatolian part of İstanbul. First of all, the differences in climatic parameters between the two stations were analyzed. Then, the relationship of PSA levels with daily minimum, maximum and average temperatures along with moisture levels recorded by the two stations was statistically evaluated. ResultsThe mean age of the subjects was 48.52 (15-90) years and the percentage of individuals in age groups below 30, 31-40, 41-50 and over 50 were 5.2%, 23.2%, 31.8%, and 39.8%, respectively. The mean prostate volume measured by ultrasonography was 30.52 ml which increased with age in compatible with the literature. The mean PSA value was 1.19 ng/ml in all age groups. PSA values were higher in older participants and in those with larger prostate volume. Only PSA and mean humidity levels were statistically different between the two stations (p<0.05). When all parameters of temperature and humidity were grouped according to the Prostate specific anigen (PSA) is still the only available proven laboratory test in clinician's hands for prostate cancer screening. However, many factors can cause a change in serum levels of PSA. This study is undertaken to determine the possible effect of climate parameters on individuals' PSA levels.

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Section: Discussionmentioning

confidence: 84%

Effect of Temperature and Humidity on Serum Prostate Specific Antigen Levels in Asymptomatic Male Population

Eren¹,

Özveri²,

Coşgun³

2016

jus

View full text Add to dashboard Cite

show abstract

“…Previous studies examined fluctuations in various tumor markers in cancer-free patients. For example, epidemiological studies clearly showed an elevation in PSA in summer in prostate cancer patients [ 20 , 21 ]. The most plausible explanation is that physical activity during summer may be associated with a transient increase in PSA [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Unexplained increases in serum carcinoembryonic antigen levels in colorectal cancer patients during the postoperative follow-up period: an analysis of its incidence and longitudinal pattern

Nozawa,

Yokota,

Emoto

et al. 2023

Annals of Medicine

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Background Carcinoembryonic antigen (CEA) monitoring facilitates the detection of recurrence in patients with colorectal cancer (CRC) after resection. False-positive CEA has been reported in CRC patients with certain comorbidities or smokers. However, limited information is currently available on the frequency of and changes in falsely elevated CEA levels in patients without these conditions. Materials and methods We retrospectively examined CRC patients who underwent surgical resection at our hospital between 2001 and 2017, had no recurrence for at least five years, and were free of known factors that may increase CEA. Postoperative CEA levels were retrieved until 2 years before the last contact. For comparison, we similarly selected patients who developed recurrence after resection of CRC during the same period, and CEA levels at initial presentation, at nadir, and at the time of recurrence were reviewed. The patterns of elevated CEA (>5 ng/ml) were classified as transient, repeated, or persistent based on longitudinal changes. The relationships between CEA and carbohydrate antigen 19-9, transaminases, creatinine, and C-reactive protein were examined. Results CEA elevation occurred in 90 (20%) out of 446 eligible patients without recurrence at least once during the mean postoperative period of 50.5 months, whereas CEA was >5 ng/ml in 117 (53%) of 221 patients when they developed recurrence. Twenty-seven patients without recurrence showed a transient elevation in CEA, 45 repeated elevations, and 18 a persistent elevation; the frequency of a high preoperative CEA level increased in this order. The majority (98%) of false elevations ranged between 5 and 15 ng/ml. CEA was not associated with other laboratory data. Conclusions Unexplained CEA elevations were observed in 20% of recurrence-free CRC patients after surgery, and were classified into three patterns based on longitudinal changes. A more detailed understanding of patient-specific fluctuations in CEA will prevent unnecessary imaging studies and reduce medical costs.

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“…Simşek et al [ 18 ] showed that the mean serum PSA level in the spring showed a higher value when compared with winter, fall, and summer mean levels. However, some studies show that seasonal variation is not correlated with the serum PSA level [ 19 20 ]. Because of these contradictory results and the unknown etiology of variations in PSA levels, a more careful approach and follow-up should be considered when treating LUTS/BPH patients.…”

Section: Discussionmentioning

confidence: 99%

Seasonal Variation of Urinary Symptoms in Korean Men with Lower Urinary Tract Symptoms and Benign Prostatic Hyperplasia

Choi

Kwon

Lee

et al. 2015

World J Mens Health

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PurposeTo examine seasonal variations in urinary symptoms in Korean men with lower urinary tract symptoms and benign prostatic hyperplasia (LUTS/BPH).Materials and MethodsRecords were obtained from a consecutive database of LUTS/BPH patients from March 2010 to February 2014. A total of 1,185 patients were suitable for analysis. The International Prostate Symptom Score (IPSS), uroflowmetric parameters, prostate volume-related parameters, and serum prostate-specific antigen levels were evaluated.ResultsBased on the month during which they were examined, patients were categorized into cold, hot, or intermediate season groups. The IPSS score was significantly different between the cold and the hot season groups (17.3±6.9 vs. 16.1±7.4, respectively; p=0.020). Storage symptom scores were significantly aggravated in the cold (6.8±3.3; p=0.030) and intermediate groups (6.9±3.5; p=0.032) compared with the hot season group (6.3±3.4), with this observation primarily driven by the individual scores for frequency and urgency. Quality of life (QOL) scores were worse in the cold compared with the hot season group (4.0±1.1 vs. 3.8±1.1, respectively; p=0.012). There were also significant differences between the cold and hot season groups in voided volume (278.7±148.5 vs. 255.9±145.1, respectively; p=0.034) and postvoid residual volume (26.4±37.6 vs. 32.2±41.0, respectively; p=0.039).ConclusionsDifferent urinary symptoms and uroflowmetric parameters were associated with changes in seasons. QOL and IPSS parameters might be worse in cold weather seasons compared with hot weather seasons.

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Daily, monthly and seasonal variation in PSA levels and the association with weather parameters

Cited by 7 publications

References 20 publications

Effect of Temperature and Humidity on Serum Prostate Specific Antigen Levels in Asymptomatic Male Population

Effect of Temperature and Humidity on Serum Prostate Specific Antigen Levels in Asymptomatic Male Population

Unexplained increases in serum carcinoembryonic antigen levels in colorectal cancer patients during the postoperative follow-up period: an analysis of its incidence and longitudinal pattern

Seasonal Variation of Urinary Symptoms in Korean Men with Lower Urinary Tract Symptoms and Benign Prostatic Hyperplasia

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