Daily morning light therapy is associated with an increase in choroidal thickness in healthy young adults

Read, Scott A.; Woodman-Pieterse, Emily C.; Alonso‐Caneiro, David; Bormann, Rebekah; Hong, Seentinie; Lo, Chai-Hoon; Richer, Rhiannon; Syed, Atif; Tran, Linda Thuong Diem Huynh

doi:10.1038/s41598-018-26635-7

Cited by 40 publications

(42 citation statements)

References 46 publications

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“…Furthermore, this process is plausible in the literature and affects the choroidal bloodstream variations in feedback to shifting light conditions [50]. Previous investigators have demonstrated that the choroid has a relative peak thickness early in the morning and progressive decrease during the day to a relative nadir at 5:00 PM [50]. In our study, measurements of all individuals were performed between 8.00-10.00 in the morning.…”

Section: Discussionmentioning

confidence: 65%

“…The choroid is likewise well established in humans to show significant diurnal alterations in thickness, and daily rhythms of light exposure are determined to perform a pivotal role in the synchronization of these circadian rhythms [48]. One of the potential mechanisms is that the light-induced increase of retinal DA [49] results in nitric oxide (NO) release and NO leads to an increase of choroidal blood flow and density [50]. Furthermore, this process is plausible in the literature and affects the choroidal bloodstream variations in feedback to shifting light conditions [50].…”

Section: Discussionmentioning

confidence: 99%

“…One of the potential mechanisms is that the light-induced increase of retinal DA [49] results in nitric oxide (NO) release and NO leads to an increase of choroidal blood flow and density [50]. Furthermore, this process is plausible in the literature and affects the choroidal bloodstream variations in feedback to shifting light conditions [50]. Previous investigators have demonstrated that the choroid has a relative peak thickness early in the morning and progressive decrease during the day to a relative nadir at 5:00 PM [50].…”

Section: Discussionmentioning

confidence: 99%

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Insomnia Might Influence the Thickness of Choroid, Retinal Nerve Fiber and Inner Plexiform Layer

et al. 2020

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Sleep may play a fundamental role in retinal regulation and the degree of retinal variables. However, no clinical study has investigated optical coherence tomography (OCT) parameters in patients with primary insomnia. All participants were evaluated with the insomnia severity index (ISI) and the Pittsburgh sleep quality index (PSQI). The retinal nerve fiber layer (RNFL), ganglion cell layer (GC), inner plexiform layer (IPL), macula and choroidal (CH) thickness were compared between 52 drug-naïve patients with primary insomnia and 45 age-gender-BMI-smoke status matched healthy controls (HC). The patients with primary insomnia differed from the HC regarding RNFL-Global (p = 0.024) and RNFL-Nasal inferior (p = 0.010); IPL-Temporal (p < 0.001), IPL-Nasal (p < 0.001); CH-Global (p < 0.001), CH-Temporal (p = 0.004), CH-Nasal (p < 0.001), and CH-Fovea (p = 0.019). ISI correlated with RNFL-Global and RNFL-Nasal inferior. The regression analysis revealed that ISI was the significant predictor for the thickness of RNFL- Nasal inferior (p = 0.020), RNFL-Global (p = 0.031), and CH-Nasal (p = 0.035) in patients with primary insomnia. Sleep disorders are seen commonly in patients with psychiatric, including ocular diseases. Adjusting the effect of insomnia can help to clarify the consistency in findings of OCT.

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Section: Discussionmentioning

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Insomnia Might Influence the Thickness of Choroid, Retinal Nerve Fiber and Inner Plexiform Layer

et al. 2020

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“…Recently, in a population of young adults, a one‐week period of increased light exposure in the morning delivered through the use of light therapy glasses for 30 minutes each morning (these light emitting glasses deliver ~500 lux of green light to the eye, and have previously been used to treat sleep disturbances and seasonal affective disorder) was found to result in a small‐magnitude increase in choroidal thickness . The changes observed in the choroid were characterised by a small overall thickening of the choroid coupled with an increase in the diurnal amplitude of variation in choroidal thickness, with the larger increases in choroidal thickness following light therapy generally observed in the evening (Figure ).…”

Section: Changes In the Choroid Associated With Environmental Factorsmentioning

confidence: 99%

“…Effects of daily morning light therapy on choroidal thickness. The mean daily changes in choroidal thickness between 9:00 and 21:00 hours in healthy young adult subjects prior to light therapy (baseline, black line), and following a one‐week period of daily morning light therapy (green line) . Light therapy was delivered through the use of commercially available light therapy glasses (see inset image) that were worn for 30 minutes each morning for a seven‐day period.…”

Section: Changes In the Choroid Associated With Environmental Factorsmentioning

confidence: 99%

Choroidal changes in human myopia: insights from optical coherence tomography imaging

Read

Fuss

Vincent

et al. 2019

Clinical and Experimental Optometry

121

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The choroid is a vascular tissue which plays a range of critical roles in the normal physiology of the eye, such as supplying the outer retina with oxygen and nutrients and the regulation of intraocular pressure. There is also substantial evidence, particularly from animal studies, that the choroid plays an important role in the regulation of eye growth and the development of common refractive errors like myopia. In recent years, advances in optical coherence tomography technology have improved our ability to image and measure the choroid in the human eye. Research using this technology over the past decade has dramatically improved our knowledge of the normal choroid, and its potential role in the regulation of eye growth and refractive error development. This review aims to provide an overview of recent work examining the normal human choroid, its changes with myopia and the possible role of the choroid in the mechanism regulating eye growth. Studies have demonstrated that choroidal thinning accompanies the development and progression of myopia, and have established a close link between eye growth and choroidal thickness changes. Dramatic thinning of the choroid is seen with high myopia, and associations are also observed between choroidal thinning and reduced vision, and the development of retinal pathology associated with high myopia. In the short-term, environmental factors known to be associated with myopia development and more rapid eye growth typically lead to a thinning of the choroid, whereas factors linked to a slowing of eye growth are typically associated with short-term choroidal thickening. Collectively, these findings suggest that the choroid is an important biomarker of eye growth in the human eye, and additional research to better understand the human choroid is likely to further our knowledge of the signals and pathways regulating eye growth, myopia development and progression.

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Light Signaling and Myopia Development: A Review

Zhang

Zhu

2022

Ophthalmol Ther

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Introduction:The aim of this article was to comprehensively review the relationship between light exposure and myopia with a focus on the effects of the light wavelength, illuminance, and contrast on the occurrence and progression of myopia. Methods: This review was performed by searching PubMed data sets including research articles and reviews utilizing the terms ''light'', ''myopia'', ''refractive error'', and ''illuminance'', and the review was concluded in November 2021. Myopia onset and progression were closely linked with emmetropization and hyperopia. To better elucidate the mechanism of myopia, some of the articles that focused on this topic were included. This article is based on previously conducted studies and does not contain any new studies with human participants or animals performed by any of the authors. Results: The pathogenesis and prevention of myopia are not completely clear. Studies have provided evidence supporting the idea that light could affect eye growth in three ways. Changing the corresponding conditions will cause changes in the growth rate and mode of the eyes, and preliminary results have shown that FR/NIR (far red/near-infrared) light is effective for myopia in juveniles. Conclusion: This review discusses the results of studies on the effects of light exposure on myopia with the aims of providing clues and a theoretical basis for the use of light to control the development of myopia and offering new ideas for subsequent studies.

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Daily morning light therapy is associated with an increase in choroidal thickness in healthy young adults

Cited by 40 publications

References 46 publications

Insomnia Might Influence the Thickness of Choroid, Retinal Nerve Fiber and Inner Plexiform Layer

Insomnia Might Influence the Thickness of Choroid, Retinal Nerve Fiber and Inner Plexiform Layer

Choroidal changes in human myopia: insights from optical coherence tomography imaging

Light Signaling and Myopia Development: A Review

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