Daily Profiles of Dehydroepiandrosterone and Its Hydroxylated Metabolites with Respect to Food Intake

Vítků³

et al. 2015

The cyclical effects of hormones during the menstrual cycle (MC) are not just responsible for driving ovulation, but also have significant influence on dietary intake and appetite, as well as psychological and behavioral changes. The aim of our study was to describe changes and relationships between the MC and selected steroids, adipokines and food intake-related hormones.Twenty-seven women with regular menstrual cycles were included in the study, and their hormonal spectrum was measured in regular intervals starting from the first day of their cycle. Classical changes in gonadotropins, estrogens and progesterone during the menstrual cycle are accompanied by less striking but significant changes in 17-hydroxyprogesterone and testosterone. No significant changes show dehydroepiandrosterone and its 7-oxygenated metabolites. Adipokines show a tendency to increase during ovulation, while ghrelin and resistin decrease. There is also a remarkable association of sex hormone-binding globulin on the day of the cycle. Our results demonstrate that changes to adipokines during the menstrual cycle are not substantial, but nonetheless can play a role in the changes of food intake described in the literature. Precise descriptions of physiological changes in healthy women are important in helping us understand the significance of the changes accompanying various pathological states.

Section: Vol 64mentioning

confidence: 99%

Levels of Adipokines and Some Steroids During the Menstrual Cycle

Šrámková¹,

Vítků³

et al. 2015

“…Only rare reports have dealt with other steroid hormones. Some data were published on dehydroepiandrosterone (Stárka et al 2015) and its hydroxymetabolites, no data could we find for allopregnanolone or pregnenolone. However, in many situations, particularly for neuroactive metabolites, these steroids can extensively modulate many brain functions like mood or behavior.…”

Section: Introductionmentioning

confidence: 61%

Daily Profiles of Steroid Hormones and Their Metabolites Related to Food Intake

Rácz

Vondra³

et al. 2015

The aim of this study was to look for changes in the daily profile of steroid hormones after standardized food intake. Eight young women not taking contraceptives were followed from 5:30 a.m. till 9:30 p.m. before and 1 and 2 h after eating breakfast, snack, lunch, the second snack and dinner. The differences in steroid levels before and after meals were evaluated. As expected, glucose, C-peptide and ghrelin levels changed postprandially. The steroid hormones cortisol, progesterone, pregnenolone and dehydroepiandrosterone showed a decrease after main meals, whereas testosterone and dihydrotestosterone showed no significant dependence on food intake. Estrogen levels did not exhibit a significant nycthemeral rhythm, but estradiol decreased after main meals. In our study the known nycthemeral rhythm of LH, FSH, cortisol, progesterone and pregnenolone after food intake were confirmed, but significant changes after meals were also observed in the levels of cortisol, dehydroepiandrosterone, estradiol and SHBG.

“…Changes in DHEA concentrations over the course of life are similar to DHEAS. However, in contrast to DHEAS DHEA has a clear diurnal profile, matching that of cortisol (Stárka et al 2015). Changes during the menstrual cycle are minor, with a slight increase in the late luteal phase (Šrámková et al 2015).…”

Section: Dehydroepiandrosterone (Dhea)mentioning

confidence: 99%

“…Only a few laboratories offer DHT assays. More accurate results can be obtained using liquid chromatography, but this method is used rather for research purposes (Swerdloff et al 2017).…”

Section: Dihydrotestosterone (Dht)mentioning

confidence: 99%

“…Daily changes in DHT levels are not marked, though some studies have described decreases after awakening and in reaction to food intake (Racz et al 2015). Unlike testosterone, changes during the menstrual cycle have not yet been described (Swerdloff et al 2017), but this could be due to the analytical problems when analyzing minor changes. However, even assays using gas chromatography have not been able to demonstrate changes during the cycle or in the course of aging in low DHT levels in women (0.24-0.75 nmol/l) (Kannenberg et al 2018).…”

Section: Dihydrotestosterone (Dht)mentioning

confidence: 99%

See 1 more Smart Citation

Androgens in Women – Critical Evaluation of the Methods for Their Determination in Diagnostics of Endocrine Disorders

Kolátorová²,

Stárka³

2018

The androgens dehydroepiandrosterone sulfate, dehydro-epiandrosterone, androstenedione and testosterone are routinely assessed in women, and circulating levels of these androgens reflect their production. These androgens are measured in most laboratories using various immuno-analytical methods. Recently, however, androgen assays have begun to be performed using gas or liquid chromatography combined with mass spectrometry. To better understand the difficulties and issues of androgen laboratory diagnostics, it is important to assess each of the methods used, how and why they were introduced into practice, and their advantages, limits, historic milestones and current status. It is also necessary to understand how reference ranges are determined and specifics arising from the physiology of individual androgens. Here we present a summary and discussion of these issues.