Daily rhythm of serum melatonin in patients with dementia of the degenerate type

Uchida, Katsuhisa; Okamoto, Norio; Ohara, Kenshiro; Morita, Yukitomo

doi:10.1016/0006-8993(96)00086-8

Cited by 134 publications

(82 citation statements)

References 24 publications

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“…Dementia patients have been noted to have abnormalities in their rhythms of melatonin secretion. 47,48 This dysfunction has been noted not only in patients with clinical diagnosis of AD, 9 but confirmed after postmortem analysis. 49 Light therapy, given after the temperature nadir, may also be an appropriate treatment.…”

Section: Commentmentioning

confidence: 97%

Differential Circadian Rhythm Disturbances in Men with Alzheimer Disease and Frontotemporal Degeneration

Harper¹,

Stopa²,

McKee³

et al. 2001

Arch Gen Psychiatry

218

111

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Background: Caregiver exhaustion is a frequent consequence of sleep disturbance and rest-activity rhythm disruption that occurs in dementia. This exhaustion is the causal factor most frequently cited by caregivers in making the decision to institutionalize patients with dementia. Recent studies have implicated dysfunction of the circadian pacemaker in the etiology of these disturbances in dementia.

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Section: Commentmentioning

confidence: 97%

Differential Circadian Rhythm Disturbances in Men with Alzheimer Disease and Frontotemporal Degeneration

Harper¹,

Stopa²,

McKee³

et al. 2001

Arch Gen Psychiatry

218

111

View full text Add to dashboard Cite

show abstract

“…Alterations in the circadian rhythm of body temperature, activity, and sleep have been reported in AD patients (17,18), suggesting impairments in the SCN in this neurodegenerative disorder (14,15). The possible influence of circadian rhythm on cognitive functions has been also observed in AD patients whose behavioral symptoms of dementia are exacerbated in the afternoon and evening, a phenomenon known as ''sundowning'' (42).…”

Section: Fig 3 Effects Of Siv Infection On the Circadian Rhythm Of mentioning

confidence: 98%

“…It has been hypothesized that impairments in circadian control mechanisms could cause disorders in numerous functions regulated by the CNS, as well as alterations in cognitive processes. For instance, deterioration of the control of circadian rhythm in patients with Alzheimer's disease (AD) (14,15) leads to disruptions in the secretion of melatonin and body temperature rhythm alterations (16,17). These, in turn, affect the distribution of the sleep/wake patterns and are associated with cognitive impairments (18).…”

mentioning

confidence: 99%

Effects of simian immunodeficiency virus on the circadian rhythms of body temperature and gross locomotor activity

Huitrón‐Reséndiz

Marcondes

Flynn

et al. 2007

Proc. Natl. Acad. Sci. U.S.A.

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In monkeys infected with simian immunodeficiency virus (SIV), changes in body temperature and locomotor activity occur after the acute retroviral syndrome stage of the disease. However, alterations to the circadian rhythm of these factors in SIV-infected monkeys have not been reported. To determine whether the circadian rhythm of body temperature and locomotor activity are disrupted during SIV infection, we analyzed the temperature and activity patterns of SIV-infected monkeys through different stages of the disease, progressing to SIV encephalitis by using the cosinor model for circadian oscillation. We found that SIV infection resulted in significant impairments of the amplitude and mean of the circadian rhythm of body temperature and activity and in the acrophase of the circadian rhythm for temperature. These alterations were not related to changes observed in the acute febrile response induced after viral inoculation. In animals killed once marked circadian anomalies were evident, microglia infiltration and macrophage accumulation in the hypothalamus were observed. Together, these results clearly demonstrate that SIV infection compromises aspects of circadian regulation in monkeys, with important implications for physiological functions, including cognition, in HIV-infected individuals.AIDS ͉ CNS ͉ dementia ͉ HIV

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“…Studies of melatonin levels in AD patients reveal that they are lower in AD patients compared to age matched controls [73][74][75][76]. Decreased CSF melatonin levels in AD patients were attributed to decreased melatonin production rather than to diluting effects of CSF.…”

Section: Melatonin Levels In Alzheimer's Diseasementioning

confidence: 98%

Alzheimer’s Disease: Focus on the Neuroprotective Role of Melatonin

Srinivasan¹

2012

J Neurol Res

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Alzheimer's disease (AD) is characterized by a progressive loss of memory and cognitive function, and by behavioural and sleep disturbances, including insomnia. The pathophysiology of AD has been attributed to oxidative stress-induced amyloid-β protein (Aβ) deposition. Abnormal tau protein, mitochondrial dysfunction and protein hyper-phosphorylation have been demonstrated in neural tissues of AD patients. AD patients exhibit severe sleep-wake disturbances and these sleep disturbances are associated with rapid cognitive decline and memory impairment. Optimally effective management of AD patients will likely require a drug that can arrest Aβ -induced neurotoxic effects and can also restore the disturbed sleep-wake rhythm, with improvement in sleep quality. In this context, the pineal hormone melatonin has been demonstrated to be an effective antioxidant that can prevent Aβ -induced neurotoxic effects through a variety of mechanisms. Sleep deprivation itself produces many effects including oxidative damage, impaired mitochondrial function, neurodegenerative inflammation, altered proteosomal processing and abnormal activation of enzymes. In addition to treating the signs and symptoms of AD, treatment of sleep disturbances may also be necessary for preventing and arresting AD progression. Besides melatonin, a number of melatonergic agonists such as ramelteon, agomelatine and tasimelteon are now used clinically for treating insomnia and other sleep disorders. Their use may also be beneficial in treating Alzheimer's disease.

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Daily rhythm of serum melatonin in patients with dementia of the degenerate type

Cited by 134 publications

References 24 publications

Differential Circadian Rhythm Disturbances in Men with Alzheimer Disease and Frontotemporal Degeneration

Differential Circadian Rhythm Disturbances in Men with Alzheimer Disease and Frontotemporal Degeneration

Effects of simian immunodeficiency virus on the circadian rhythms of body temperature and gross locomotor activity

Alzheimer’s Disease: Focus on the Neuroprotective Role of Melatonin

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