Daily rhythms of catalase and glutathione peroxidase expression and activity are endogenously driven in the hippocampus and are modified by a vitamin A-free diet

Navigatore-Fonzo, Lorena; Delgado, Silvia Marcela; Giménez, María Sofía; Anzulovich, Ana Cecilia

doi:10.1179/1476830513y.0000000062

Cited by 12 publications

(5 citation statements)

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“…In our model, VAD reduced the mesor, increased the amplitude, and modified the phase of GSH rhythm in the rat hippocampus. Alterations in the circadian rhythmicity of clock factors caused by the VAD might be responsible for changes in antioxidant enzymes circadian expression and activity (previously reported data [50]) and, consequently, in modifying GSH rhythm. Thus, this leads to a poorer antioxidant environment and an increased oxidative stress as well as deleterious effects at the first half of the dark period, which is the time that Winocur and Hasher [51] demonstrated as the most suitable for conducting memory and learning tests in young rats.…”

Section: Discussionmentioning

confidence: 80%

Circadian rhythms of locomotor activity and hippocampal clock genes expression are dampened in vitamin A–deficient rats

et al. 2014

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Section: Discussionmentioning

confidence: 80%

Circadian rhythms of locomotor activity and hippocampal clock genes expression are dampened in vitamin A–deficient rats

et al. 2014

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“…A number of groups have investigated the effect of circadian rhythms on antioxidants [ 11 , 33 , 53 , 54 ] but none have directly investigated the effect of the 24-h cycle on ROS levels. All have reported variations in the numerous antioxidant defence systems across a 24-h period which may be representative of the dynamics associated with scavenging oxidant molecules such as H 2 O 2 .…”

Section: Resultsmentioning

confidence: 99%

Real-Time Amperometric Recording of Extracellular H2O2 in the Brain of Immunocompromised Mice: An In Vitro, Ex Vivo and In Vivo Characterisation Study

Reid

Finnerty

2017

Sensors

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We detail an extensive characterisation study on a previously described dual amperometric H2O2 biosensor consisting of H2O2 detection (blank) and degradation (catalase) electrodes. In vitro investigations demonstrated excellent H2O2 sensitivity and selectivity against the interferent, ascorbic acid. Ex vivo studies were performed to mimic physiological conditions prior to in vivo deployment. Exposure to brain tissue homogenate identified reliable sensitivity and selectivity recordings up to seven days for both blank and catalase electrodes. Furthermore, there was no compromise in pre- and post-implanted catalase electrode sensitivity in ex vivo mouse brain. In vivo investigations performed in anaesthetised mice confirmed the ability of the H2O2 biosensor to detect increases in amperometric current following locally perfused/infused H2O2 and antioxidant inhibitors mercaptosuccinic acid and sodium azide. Subsequent recordings in freely moving mice identified negligible effects of control saline and sodium ascorbate interference injections on amperometric H2O2 current. Furthermore, the stability of the amperometric current was confirmed over a five-day period and analysis of 24-h signal recordings identified the absence of diurnal variations in amperometric current. Collectively, these findings confirm the biosensor current responds in vivo to increasing exogenous and endogenous H2O2 and tentatively supports measurement of H2O2 dynamics in freely moving NOD SCID mice.

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“…Dean reported that glutathione deficiency induces oxidative damage to short term spatial memory in rats and mice in the Y-maze test (45). Meanwhile, it was demonstrated that CAT and GSH-Px expression in the brain tissue were altered endogenously in the rat hippocampus affected by nutritional vitamin A deficiency, which can impair the temporal orchestration of hippocampal daily cognitive performance (16). Finally, in terms of cognitive functioning, as oxidative stress biomarkers have been found to be related to the cognitive performance of healthy elderly subjects and those with Alzheimer's disease (46), we can conclude that there appears to be a relationship between oxidative stress parameters and SZ in this study.…”

Section: Discussionmentioning

confidence: 99%

“…Whether the oxidative/anti-oxidative status relates to clinical status of SZ is of particular interest. Numerous studies have explored the relationship between ROS and the severity of different clinical dimensions in schizophrenia (3,15), and found the complex changes of OS have been linked to cognitive impairment and psychiatric symptoms in both preclinical and clinical studies (16)(17)(18). Such as, serum SOD, GSH-Px were shown to correlate with overall severity in acute phase (19).…”

Section: Introductionmentioning

confidence: 99%

Cognitive Impairment and Psychopathology Are Related to Plasma Oxidative Stress in Long Term Hospitalized Patients With Chronic Schizophrenia

Yang

et al. 2022

Front. Psychiatry

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BackgroundThe present study aimed to examine whether plasma oxidative stress is associated with cognitive impairment in long term hospitalized patients with chronic schizophrenia.MethodNinety-six chronic schizophrenia patients and 94 healthy unaffected subjects were enrolled. Plasma markers of oxidative stress, including malondialdehyde (MDA), manganese superoxide dismutase (MnSOD), catalase (CAT), and glutathione peroxidase (GSH-Px), were measured. Psychiatric symptoms and cognitive function were assessed with the Positive and Negative Syndrome Scale (PANSS) and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), respectively.ResultsPlasma MDA levels and MnSOD and GSH-Px activities were significantly lower in schizophrenia patients than in healthy controls (P < 0.001), while plasma CAT activity was higher than in healthy controls (P < 0.005). Cognitive scores on the RBANS and all of its five subscales (all P < 0.001) were significantly lower in schizophrenia patients than in healthy unaffected subjects. CAT and GSH-Px activities were positively correlated with the cognitive function scores corresponding to Visuospatial/Constructional abilities in the patient group (r = 0.298, 0.213, respectively, P < 0.05). Also, the multiple regression analysis revealed that CAT and GSH-Px activities were independent and separate contributors to the Visuospatial/Constructional index of the RBANS. Meanwhile, CAT activity was negatively correlated with general pathological symptoms (r = −0.307, Bonferroni corrected P = 0.008) and the total score of the PANSS domains (r = −0.299, Bonferroni corrected P = 0.012).ConclusionOur results that the reduced of MDA level and the increased CAT activity in plasma in male patients with chronic schizophrenia suggest that redox imbalance may be associated with the pathophysiology of schizophrenia, and it can induce impaired cognition and psychiatric symptoms.

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Daily rhythms of catalase and glutathione peroxidase expression and activity are endogenously driven in the hippocampus and are modified by a vitamin A-free diet

Cited by 12 publications

References 50 publications

Circadian rhythms of locomotor activity and hippocampal clock genes expression are dampened in vitamin A–deficient rats

Circadian rhythms of locomotor activity and hippocampal clock genes expression are dampened in vitamin A–deficient rats

Real-Time Amperometric Recording of Extracellular H2O2 in the Brain of Immunocompromised Mice: An In Vitro, Ex Vivo and In Vivo Characterisation Study

Cognitive Impairment and Psychopathology Are Related to Plasma Oxidative Stress in Long Term Hospitalized Patients With Chronic Schizophrenia

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