Daily rhythms of heart rate, temperature and locomotor activity are modified by anaesthetics in rats: a telemetric study

Prudian, Frederic; Gantenbein, Manon; Pélissier, A.; Attolini, Laurence; Bruguerolle, Bernard

doi:10.1007/pl00005012

Cited by 40 publications

(31 citation statements)

References 13 publications

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“…This type of anaesthesia modifies acrophase, mesor, and amplitude of the daily rhythms, but without loss of the daily rhythmicity [27,28]. The preservation of LD dependence in the HR after the surgical interventions in our experimental model does not affirm the assumption that surgery can have a more marked effect on LD dependence than the simple effect of the anaesthetic agent [28].…”

Section: The Effects Of Ld Cycle On the Cardiovascular Reactivity In contrasting

confidence: 54%

Heart-rate changes in asphyxic preconditioning in rats depend on light-dark cycle

et al. 2011

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AbstractGenerally, it is assumed that heart-rhythm disorders during hypoxia result from the interplay between the autonomic nervous system (ANS) and the direct effect of hypoxia on cardiorespiratory structures of the central nervous system and on the myocardium. Circadian variability in the ANS may substantially influence the electrical stability of the myocardium, and thus it is associated with the preconditioning protective mechanism. We designed our study using anaesthetized Wistar rats (ketamine/xylazine 100 mg/15 mg/kg, i.m., open chest experiments) to evaluate the effect of preconditioning (PC) induced by 1 to 3 cycles (1 PC–3 PC) of asphyxia (5 min. of artificial hypoventilation, VT = 0.5 ml/100 g of b.w., 20 breaths/min.) and reoxygenation (5 min. of artificial ventilation, VT = 1 ml/100 g of b.w., 50 breaths/min.) on the heart rate (HR) during followed exposure 20 minutes of hypoventilation after adaptation to a light-dark (LD) cycle of 12 hours:12 hours. Hypoxic HR increases were only minimally prevented by 1 to 2 PC pre-treatment, particularly during the dark part of the day. A statistically significant HR increase required 3 PC and was seen only in the light part of the day. We concluded that possible ANS participation in asphyxic preconditioning depends not only on the number of preconditioned cycles but also on the LD cycle, when the ANS participation in preconditioning can be effective only in the light (nonactive) period.

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Section: The Effects Of Ld Cycle On the Cardiovascular Reactivity In contrasting

confidence: 54%

Heart-rate changes in asphyxic preconditioning in rats depend on light-dark cycle

et al. 2011

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“…Some studies suggest that general anesthetics disturb the circadian rhythms in the days following. The induction of ether or ketamine anesthesia during the resting phase (light period) of rodents has been shown to alter the daily rhythms of heart rate, body temperature and locomotor activity in the days following (Prudian et al, 1997). In humans, anesthesia and surgery with operative stress delay the onset of nocturnal melatonin secretion during the first postsurgical evening, suggesting a phase shift in the circadian secretion of melatonin Karkela et al, 2002;Reber et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Reciprocal Relationships between General (Propofol) Anesthesia and Circadian Time in Rats

Challet

Gourmelen

Pévet

et al. 2006

Neuropsychopharmacol

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Several common postdischarge symptoms, such as sleep disorders, headache, drowsiness or general malaise, evoke disturbances of circadian rhythms due to jet lag (ie crossing time zones) or shift work rotation. Considering that general anesthesia is associated with numerous effects on the central nervous system, we hypothesized that it may also act on the circadian timing system. We first determined the effects of the circadian timing on general anesthesia. We observed that identical doses of propofol showed marked circadian fluctuations in duration of effects, with a peak at the middle of the resting period (ie 7 h after lights on). Then, we examined the effects of general anesthesia on circadian timing, by analysing stable free-running circadian rhythms (ie in constant environmental conditions), an experimental approach used widely in circadian biology. Free-running rats were housed in constant darkness and temperature to assess possible phase-shifting effects of propofol anesthesia according to the time of the day. When administered around (72 h) the daily rest/activity transition point, a 30-min propofol anesthesia induced a 1-h phase advance in the free-running rest-activity rhythm, while anesthesia had no significant resetting effect at other times of the day. Anesthesia-induced hypothermia was not correlated with the phase-shifting effects of propofol anesthesia. From our results, anesthesia itself can reset circadian timing, and acts as a synchronizing cue for the circadian clock. Neuropsychopharmacology (2007) 32, 728-735.

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“…Light-dark dependence of electrocardiographic changes during asphyxia and reoxygenation in a rat model not in the PQ interval. This means that the significant LD differences in ECG parameters refer to fact that ketamine/xylazine anaesthesia does not disturb lightdark dependence, but it can modify acrophase, mesor, and amplitude of the circadian rhythms without loss of daily rhythmicity [34,35]. We found that circadian rhythm was present in the rats' heart rate before implantation of the transmitters (for the recording of heart rate) and that non-detection of a daily rhythm after implantation of the transmitters under general anaesthesia was essentially due to surgical aggression; the general anaesthetic agent was responsible only for perturbations of the characteristics of this rhythm.…”

Section: Discussionmentioning

confidence: 99%

Light-dark dependence of electrocardiographic changes during asphyxia and reoxygenation in a rat model

et al. 2010

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AbstractThe aim of this study was to evaluate the effect of ventilation on electrocardiographic time intervals as a function of the light-dark (LD) cycle in an in vivo rat model. RR, PQ, QT and QTc intervals were measured in female Wistar rats anaesthetized with both ketamine and xylazine (100 mg/15 mg/kg, i.m., open chest experiments) after adaptation to the LD cycle (12:12h) for 4 weeks. Electrocardiograms (ECG) were recorded before surgical interventions; after tracheotomy, and thoracotomy, and 5 minutes of stabilization with artificial ventilation; 30, 60, 90 and 120 seconds after the onset of apnoea; and after 5, 10, 15, and 20 minutes of artificial reoxygenation. Time intervals in intact animals showed significant LD differences, except in the QT interval. The initial significant (p<0,001) LD differences in PQ interval and loss of dependence on LD cycle in the QT interval were preserved during short-term apnoea-induced asphyxia (30–60 sec) In contrast, long-term asphyxia (90–120 sec) eliminated LD dependence in the PQ interval, but significant LD differences were shown in the QT interval. Apnoea completely abolished LD differences in the RR interval. Reoxygenation restored the PQ and QT intervals to the pre-asphyxic LD differences, but with the RR intervals, the LD differences were eliminated. We have concluded that myocardial vulnerability is dependent on the LD cycle and on changes of pulmonary ventilation.

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Daily rhythms of heart rate, temperature and locomotor activity are modified by anaesthetics in rats: a telemetric study

Cited by 40 publications

References 13 publications

Heart-rate changes in asphyxic preconditioning in rats depend on light-dark cycle

Heart-rate changes in asphyxic preconditioning in rats depend on light-dark cycle

Reciprocal Relationships between General (Propofol) Anesthesia and Circadian Time in Rats

Light-dark dependence of electrocardiographic changes during asphyxia and reoxygenation in a rat model

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