Daily salt intake is an independent risk factor for pollakiuria and nocturia

Matsuo, Tomohiro; Miyata, Yasuyoshi; Sakai, Hideki

doi:10.1111/iju.13321

Cited by 41 publications

(51 citation statements)

References 31 publications

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“…In addtion, excessive salt intake is reported to be one of the most crucial determinants for Mets and lifestyle‐related diseases . Although excessive salt intake may affect the occurrence of nocturia, there is no general agreement on the relationship between salt intake and nocturia …”

Section: Introductionmentioning

confidence: 99%

“…12,13 Although excessive salt intake may affect the occurrence of nocturia, there is no general agreement on the relationship between salt intake and nocturia. [14][15][16] Unfortunately, these studies have a cross-sectional design, and there is a need for prospective studies to clarify the clinical roles of salt intake. In this prospective study, we aimed to investigate whether reduced salt intake can affect LUTS, including nocturia and to determine whether salt intake reduction could be a new treatment option for these patients.…”

Section: Introductionmentioning

confidence: 99%

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Effect of salt intake reduction on nocturia in patients with excessive salt intake

Matsuo

Miyata

Sakai

2019

Neurourology and Urodynamics

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Aims To assess the efficacy of salt reduction for improving nocturia in patients with high salt intake. Methods Changes in lower urinary symptoms and frequency volume chart by salt intake (men: 8 g/day; women: ≥7 g/day) were analyzed in this prospective study. Patients were instructed to use a brochure for salt intake restriction via interview once every four weeks. The daily salt intake was estimated by using spot urine samples. Results Two‐hundred twenty‐three (69.5%) patients were successful in reducing their daily salt intake (S group), whereas 98 (30.5%) patients failed to reduce their salt intake (F group). In the S group, nocturia improved from 2.3 ± 0.9 to 1.4 ± 1.0, and nocturnal polyuria index (NPi) improved from 30.2 ± 7.5 to 27.7 ± 7.3% (P < 0.001). In the Core Lower Urinary Tract Symptom Score (CLSS) of the S group, Q3 (urgency) improved from 1.0 ± 1.0 to 0.9 ± 1.0 (P = 0.001); Q1 (diurnal frequency) (P < 0.001), and Q2 (nocturia) also improved (P < 0.001). Moreover, the quality of life parameter improved significantly (P < 0.001). The patients in the F group did not have improvements in any symptom during the study period. Conclusions Patients with nocturia who also have high salt intake should be advised to reduce their salt intake, as a lifestyle modification. Our results support the importance of randomized clinical trials with larger populations and the appropriate inclusion/exclusion criteria to conclude the clinical usefulness of salt reduction in this patient cohort.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of salt intake reduction on nocturia in patients with excessive salt intake

Matsuo

Miyata

Sakai

2019

Neurourology and Urodynamics

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“…Fourth, many of the patients might have opted to consume vegetables to control their hyperglycemia. Fifth, in a previous study, the intake of salt and water affected nocturia 31,32 , but we could not estimate the intake of salt and water in the present study. Nocturia is likely a multifactorial disorder, and we could not rule out residual confounding factors.…”

Section: Discussionmentioning

confidence: 62%

Dietary intake habits and the prevalence of nocturia in Japanese patients with type 2 diabetes mellitus

Furukawa

Sakai

Niiya

et al. 2017

J of Diabetes Invest

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Aims/IntroductionNo reports have been published on the association between dietary intake habits and nocturia in the diabetes population. We therefore evaluated this issue among Japanese patients with diabetes mellitus.Materials and MethodsStudy participants in the present study were 785 Japanese patients with type 2 diabetes mellitus. Self‐administered questionnaires were used to assess each type of dietary intake habit. Vegetable intake habit was assessed by the following question: “Do you have vegetables or seaweed every day?” We used the following two outcomes: (i) nocturia: ≥2 voids per night; and (ii) severe nocturia: ≥3 voids per night. Adjustment was made for age, sex, body mass index, glycated hemoglobin, hypertension, dyslipidemia, smoking, drinking, exercise habit, stroke, ischemic artery disease, diabetic nephropathy, diabetic neuropathy and diabetic retinopathy.ResultsThe prevalence of nocturia, severe nocturia, and vegetable intake habit was 39.9%, 14.4% and 67.3%, respectively. After adjusting for confounding factors, vegetable intake habit was independently inversely associated with nocturia and severe nocturia: the adjusted odds ratios were 0.67 (95% confidence interval [CI] 0.48–0.94) and 0.46 (95% CI 0.30–0.71), respectively. Among male patients, vegetable intake habit was independently inversely associated with severe nocturia, but not nocturia: the adjusted OR was 0.51 (95% CI 0.29–0.88). Among female patients, vegetable intake habit was independently inversely associated with nocturia and severe nocturia: the adjusted ORs were 0.44 (95% CI 0.24–0.79) and 0.34 (95% CI 0.15–0.78), respectively.ConclusionsWe found an inverse association between vegetable intake habit and nocturia in Japanese patients with type 2 diabetes mellitus.

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“…In addition, Kamperis et al reported that nocturnal polyuria in children with nocturnal enuresis resistant to ddavp treatment resulted from augmented sodium and urea excretion. Furthermore, a study conducted in adults also showed that excessive daily salt intake resulted in a high risk of increased daytime urination as well as nocturia . Together, these findings suggest that salt intake may affect ddavp therapy.…”

Section: Introductionmentioning

confidence: 88%

High daily salt intake had a negative impact on how well nocturnal enuresis treatment worked on children aged 7‐10 years

et al. 2019

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Aim We investigated whether the daily salt intake of children with nocturnal enuresis influenced their response to 1‐desamino‐8‐D‐arginine vasopressin therapy. Methods This study comprised 129 children (67.4% boys) with a median age of 9.2 years (range 7.2‐10.4) with monosymptomatic nocturnal enuresis who were seen at Kansai Medical University Hospital, Osaka, Japan, from 2013 to 2017. Urinary sodium concentrations were determined using a spot urine test, and the children were divided into appropriate (n = 55) and excessive salt intake (n = 74) groups based on Japanese Government guidelines. After a month of therapy, the treatment responses were compared for 39 and 50 children, respectively. Results There were no significant differences in the urea nitrogen‐to‐creatinine or calcium‐to‐creatinine ratios in the two groups. However, the excessive salt intake group showed a significantly reduced treatment response to the appropriate salt intake group. In addition, the excessive and appropriate salt intake groups showed median efficacy ratios of 8.2% and 21.8%, respectively, based on intention‐to‐treat analysis (P = 0.029) and 12.0% and 30.8% based on per‐protocol analysis (P = 0.029). Conclusion High daily salt intake significantly reduced the efficacy of ddavp therapy for nocturnal enuresis and consumption should be controlled during treatment.

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Daily salt intake is an independent risk factor for pollakiuria and nocturia

Cited by 41 publications

References 31 publications

Effect of salt intake reduction on nocturia in patients with excessive salt intake

Effect of salt intake reduction on nocturia in patients with excessive salt intake

Dietary intake habits and the prevalence of nocturia in Japanese patients with type 2 diabetes mellitus

High daily salt intake had a negative impact on how well nocturnal enuresis treatment worked on children aged 7‐10 years

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