Daily Setup Accuracy, Side-effects and Quality of Life During and After Prone Positioned Prostate Radiotherapy

Varga, Linda; Kószó, Renáta; Fodor, Emese; Cserháti, Adrienn; Varga, Zoltán; Darázs, Barbara; Kahán, Zsuzsanna; Hidéghety, Katalin; Borzási, Emőke; Szabó, Dorottya; Müllner, Kitti; Maráz, Anikó

doi:10.21873/anticanres.12648

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“…Our study was limited by the lack of delineating the penile bulb, and the relatively small number of patients involved, which however was double the number of patients previously reported. As most papers have described larger intrafraction prostate motion in prone position [8] and literature data [55] show that a 3 mm PTV margin allows for CTV to be covered for 99% of cases when daily CBCT is used, accurate patient repositioning, daily reconstruction of the rectum, prostate safety margins, early toxicity and life quality during and after RT were also evaluated, and found to be similar to literature data of patients treated in supine position [56].…”

Section: Pqi According To Technique In Patients Receiving Partial Brementioning

confidence: 54%

Individualised radiotherapy serving reduced toxicity in breast and prostate cancer

Kószó¹

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The presence of normal tissues in the irradiated volume limits dose escalation during pelvic radiotherapy (RT) for prostate cancer. Supine and prone positions on a belly board were compared by analyzing the exposure of organs at risk (OARs) using intensity modulated RT (IMRT). The prospective trial included 55 high risk, localized or locally advanced prostate cancer patients, receiving definitive image-guided RT. Computed tomography scanning for irradiation planning was carried out in both positions. Gross tumor volume, clinical and planning target volumes (PTV) and OARs were delineated, defining subprostatic and periprostatic rectal subsegments. At the height of the largest antero-posterior (AP) diameter of the prostate, rectal diameters and distance from the posterior prostate wall were measured. IMRT plans were generated. Normal tissue exposure and structure volumes were compared between supine and prone plans using paired t-test. In the volumes of the prostate, PTV, colon and small bowel, no significant differences were found. In prone position, all rectal volumes, diameters, and rectum-prostate distance were significantly higher, the irradiated colon and small bowel volume was lower in dose ranges of 20-40 Gy, and the exposure to all rectal segments was more favorable in 40-75 Gy dose ranges. No significant difference was found in the exposure of other OARs. Prone positioning on a belly board is an appropriate positioning method aiming rectum and bowel protection during pelvic IMRT of prostate cancer. The relative reduction in rectal exposure might be a consequence of the slight departure between the prostate and rectal wall.

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Section: Pqi According To Technique In Patients Receiving Partial Brementioning

confidence: 54%

Individualised radiotherapy serving reduced toxicity in breast and prostate cancer

Kószó¹

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Daily Setup Accuracy, Side-effects and Quality of Life During and After Prone Positioned Prostate Radiotherapy

Abstract: Prone positioned IG-IMRT is feasible with tolerable side-effects for high-risk PC patients. Changes in QOL and PSS are insignificant during RT, while improvement after RT suggests a rapid recovery.

Cited by 1 publication

References 16 publications

Individualised radiotherapy serving reduced toxicity in breast and prostate cancer

Individualised radiotherapy serving reduced toxicity in breast and prostate cancer

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