Daily sleep quality affects drug craving, partially through indirect associations with positive affect, in patients in treatment for nonmedical use of prescription drugs

Lydon‐Staley, David M.; Cleveland, H. Harrington; Huhn, Andrew S.; Cleveland, Michael J.; Harris, Jonathan; Stankoski, Dean; Deneke, Erin; Meyer, Roger E.; Bunce, Scott C.

doi:10.1016/j.addbeh.2016.08.026

Cited by 57 publications

(45 citation statements)

References 77 publications

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“…More positive affect was reported prior to scans during which segregation between the default mode and frontoparietal systems was greater than usual. Positive affect has been theorized to inhibit craving by facilitating self-regulation (72) and, consistent with this perspective, high positive affect is associated with reduced cravings during tobacco, alcohol, and opioid withdrawal (73,74). Results of the present study, coupled with findings that positive mood is associated with increased flexibility in large-scale brain networks (75), are consistent with the perspective that positive mood facilitates self-regulation via modulating functional connectivity associated with cognitive control.…”

Section: Discussionsupporting

confidence: 87%

Segregation of default mode from frontoparietal system protects against smoking lapse

Lydon‐Staley¹,

Rr²,

Eb³

et al. 2020

Preprint

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Quitting smoking is notoriously difficult. Models of nicotine dependence posit that deficits in cognitive control contribute to failures to maintain smoking abstinence during smoking cessation attempts. We examine the role for large-scale functional brain systems associated with cognitive control in smoking lapse. We use data from 70, five-minute functional magnetic resonance imaging (fMRI) scans in 17 daily smokers (5 female) undergoing a smoking lapse paradigm after 12 hours of smoking abstinence. Cox regression results indicate that decreased segregation of the default mode system from the frontoparietal system undermine the ability to resist smoking. Results lend support to the hypothesis that large-scale functional brain systems associated with cognitive control are implicated in smoking lapse behavior and point to the importance of cognitive control as a mechanism underlying smoking relapse.

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Section: Discussionsupporting

confidence: 87%

Segregation of default mode from frontoparietal system protects against smoking lapse

Lydon‐Staley¹,

Rr²,

Eb³

et al. 2020

Preprint

Self Cite

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“…An interesting, albeit unexpected, result was that the contemporaneous associations between discrimination and both nicotine and substance use became stronger throughout the day. Though we accounted for time-of-day and weekend vs. weekday nicotine and substance use, discrimination effects over time might relate to the opportunity to engage in both nicotine and substance use later in the day (e.g., after daily responsibilities or work), or an accumulation of factors such as cognitive fatigue, rumination, or negative affect throughout the day (Lydon-Staley et al, 2017; Aldridge-Gerry, Roesch, Villodas, McCabe, Leung, & Da Costa, 2011). …”

Section: Discussionmentioning

confidence: 99%

Ecological momentary assessment of daily discrimination experiences and nicotine, alcohol, and drug use among sexual and gender minority individuals.

Livingston¹,

Flentje²,

Heck³

et al. 2017

Journal of Consulting and Clinical Psychology

105

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Objectives Sexual and gender minority (SGM) individuals experience elevated rates of minority stress, which has been linked to higher rates of nicotine and substance use. Research on this disparity to date is largely predicated on methodology that is insensitive to within day SGM-based discrimination experiences, or their relation to momentary nicotine and substance use risk. We address this knowledge gap in the current study using ecological momentary assessment (EMA). Method Fifty SGM individuals, between 18 and 45, were recruited from an inland Northwestern University, regardless of their nicotine or substance use history, and invited to participate in an EMA study. Each were prompted to provide data, six times daily (between 10am and 10pm) for 14 days, regarding SGM-based discrimination, other forms of mistreatment, and nicotine, drug, and alcohol use since their last prompt. Results Discrimination experiences that occurred since individuals’ last measurement prompt were associated with greater odds of nicotine and substance use during the same measurement window. Substance use was also more likely to occur in relation to discrimination reported two measurements prior in lagged models. Relative to other forms of mistreatment, discrimination effects were consistently larger in magnitude and became stronger throughout the day/evening. Conclusion This study adds to existing minority stress research by highlighting the both immediate and delayed correlates of daily SGM-based discrimination experiences. These results also contribute to our understanding of daily stress processes and provide insight into ways we might mitigate these effects using real-time monitoring and intervention technology.

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“…Sleep disturbances are also common in patients receiving OST, such as methadone and buprenorphine [51]. Poor sleep quality might negatively impact outcomes and adherence to addiction treatments, and impaired sleep promotes poor executive function and negative affect, which both increase relapse risk [52,53]. Thus, in addition to reducing the activity of hyperexctiable brain circuits that promote motivated reward seeking, it is possible that suvorexant may have additional therapeutic properties in OUD patients by improving sleep quality and leading to better emotional and executive functioning [21].…”

Section: Leveraging the Sleep-promoting Effects Of Suvorexant To Redumentioning

confidence: 99%

The dual orexin/hypocretin receptor antagonist suvorexant reduces addiction-like behaviors for the opioid fentanyl

O’Connor¹,

Fragale²,

James³

et al. 2020

Preprint

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The orexin (hypocretin) system is critical for motivated seeking of all drugs of abuse, including opioids. In 2019, the National Institute on Drug Addiction (NIDA) identified the orexin system as a high priority target mechanism for novel pharmacological therapies to treat opioid use disorder (OUD).Suvorexant (Belsomra TM ) is a dual orexin receptor 1/orexin receptor 2 (OxR1/OxR2) antagonist that is FDA-approved for the treatment of insomnia, and thus has the potential to be readily repurposed for the treatment of OUD. However, studies have yet to test the therapeutic potential of suvorexant with respect to reducing opioid-related behaviors. Accordingly, here we investigated the efficacy of suvorexant in reducing several addiction-relevant behaviors in fentanyl self-administrating rats. In rats with limited drug experience, suvorexant decreased motivation for fentanyl on a behavioral economics (BE) task. This effect was greatest in rats with the highest motivation for fentanyl. Suvorexant was even more effective at decreasing motivation for fentanyl following induction of a more robust addiction phenotype by intermittent access (IntA) self-administration of the opioid. Suvorexant also attenuated punished responding for fentanyl and reduced cued reinstatement in IntA rats. Suvorexant did not affect general locomotor activity or natural reward seeking, indicating that at the doses used here, suvorexant can be used to reduce drug seeking with limited sedative or off-target effects. Together, these results highlight the therapeutic potential of suvorexant, particularly in individuals with the severe OUD.

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Daily sleep quality affects drug craving, partially through indirect associations with positive affect, in patients in treatment for nonmedical use of prescription drugs

Cited by 57 publications

References 77 publications

Segregation of default mode from frontoparietal system protects against smoking lapse

Segregation of default mode from frontoparietal system protects against smoking lapse

Ecological momentary assessment of daily discrimination experiences and nicotine, alcohol, and drug use among sexual and gender minority individuals.

The dual orexin/hypocretin receptor antagonist suvorexant reduces addiction-like behaviors for the opioid fentanyl

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