Daily Total Physical Activity and Incident Stroke

Kubota, Yasuhiko; Iso, Hiroyasu; Yamagishi, Kazumasa; Sawada, Norie; Tsugane, Shoichiro

doi:10.1161/strokeaha.117.017560

Cited by 56 publications

(36 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our data showed an inverse association between PA and risk of stroke although we were unable to further sub-type cerebrovascular events. Recent data have suggested curvilinear associations for PA and haemorrhage stroke, indicating protection at moderate PA levels and possible increased risk at very high levels of activity; in contrast very high levels of PA was not associated with increased risk of ischemic stroke in Asian populations [ 3 , 14 ], although results may differ in Western cohorts [ 15 ]. Our findings on coronary heart disease suggested a plateau in risk reduction at higher levels of PA.…”

Section: Discussionmentioning

confidence: 99%

Association between physical activity and sub-types of cardiovascular disease death causes in a general population cohort

2018

View full text Add to dashboard Cite

Physical activity is thought to be cardioprotective, but associations with different subtypes of cardiovascular disease (CVD) are poorly understood. We examined associations between physical activity and seven major CVD death causes. The sample comprised 65,093 adults (aged 58 ± 12 years, 45.4% men) followed up over mean [SD] 9.4 ± 4.5 years, recruited from The Health Survey for England and the Scottish Health Surveys. A CVD diagnosis was reported in 9.2% of the sample at baseline. Physical activity was self-reported. Outcomes were subtypes of CVD death; acute myocardial infarction; chronic ischaemic heart disease; pulmonary heart disease; a composite of cardiac arrest, arrhythmias, and sudden cardiac death; heart failure; cerebrovascular; composite of aortic aneurysm and other peripheral vascular diseases. There were 3050 CVD deaths (30.8% of all deaths). In Cox proportional hazards models adjusted for confounders, physical activity was associated with reduced relative risk of all CVD outcomes; compared with the lowest, the highest physical activity quintile was associated with reduced risk of acute myocardial infarction (Hazard ratio 0.66: 95% CI 0.50, 0.89), chronic ischaemic heart disease (0.49: 0.38, 0.64), pulmonary heart disease (0.48: 0.22, 1.07), arrhythmias (0.18: 0.04, 0.76); heart failure (0.35: 0.20, 0.63), cerebrovascular events (0.53: 0.38, 0.75); aneurysm and peripheral vascular diseases (0.54: 0.34, 0.93). Results were largely consistent across participants with and without existing CVD at baseline. Physical activity was associated with reduced risk of seven major CVD death causes. Protective benefits were apparent even at levels of activity below the current recommendations. Electronic supplementary material The online version of this article (10.1007/s10654-018-0460-2) contains supplementary material, which is available to authorized users.

show abstract

Section: Discussionmentioning

confidence: 99%

Association between physical activity and sub-types of cardiovascular disease death causes in a general population cohort

2018

View full text Add to dashboard Cite

show abstract

“…Epidemiologic studies have consistently suggested an association between PA and the risk of stroke [ 24 – 27 ]. PA is recommended to reduce the risk of first-ever and possibly the risk of recurrent stroke [ 24 , 28 – 30 ].…”

Section: Introductionmentioning

confidence: 99%

Low self-reported sports activity before stroke predicts poor one-year-functional outcome after first-ever ischemic stroke in a population-based stroke register

et al. 2018

View full text Add to dashboard Cite

BackgroundPhysical activity (PA) is associated with lower risk of stroke. We tested the hypothesis that lack of pre-stroke PA is an independent predictor of poor outcome after first-ever ischemic stroke.MethodsWe assessed recent self-reported PA and other potential predictors for loss of functional independence - modified Rankin Scale (mRS) > 2 - one year after first-ever ischemic stroke in 1370 patients registered between 2006 and 2010 in the Ludwigshafen Stroke Study, a population-based stroke registry.ResultsAfter 1 year, 717 (52.3%) of patients lost their independence including 251 patients (18.3%) who had died. In multivariate logistic regression analysis lack of regular PA prior to stroke (Odds Ratio (OR) 1.7, Confidence Interval (CI) 1.1–2.5), independently predicted poor outcome together with higher age (65–74: OR 1.7; CI 1.1–2.8, 75–84 years: OR 3.3; CI 2.1–5.3; ≥85 years OR 14.5; CI 7.4–28.5), female sex (OR 1.5; CI 1.1–2.1), diabetes mellitus (OR 1.8; CI 1.3–2.5), stroke severity (OR 1.2; CI 1.1–1.2), probable atherothrombotic stroke etiology (OR 1.8; CI 1.1–2.8) and high leukocyte count (> 9.000/mm3; OR 1.4; CI 1.0–1.9) at admission. Subclassifying unknown stroke etiology, embolic stroke of unknown source (ESUS; n = 40, OR 2.2; CI 0.9–5.5) tended to be associated with loss of independence.ConclusionIn addition to previously reported factors, lack of PA prior to stroke as potential indicator of worse physical condition, high leukocyte count at admission as indicator of the inflammatory response and probable atherothrombotic stroke etiology might be independent predictors for non-functional independence in first-ever ischemic stroke.

show abstract

“…Actually, older adults in neighborhoods with poor socioeconomic conditions have a risk for stroke in Japan . Low physical activity is a risk factor for the occurrence of and death due to cancer . It is also well known that moderate physical activity improves metabolic disorder, and prevents cardiovascular and cerebrovascular diseases .…”

Section: Discussionmentioning

confidence: 99%

“…21 Low physical activity is a risk factor for the occurrence of and death due to cancer. [22][23][24] It is also well known that moderate physical activity improves metabolic disorder, and prevents cardiovascular and cerebrovascular diseases. 22,23,25 The differences in the characteristic of individuals, such as lifestyles, or differences in the definition of low activity might explain difference results in various studies of Japanese older adults.…”

Section: Discussionmentioning

confidence: 99%