Daily variation in radiosensitivity of circulating blood cells and bone marrow cellularity of mice

Newsome-Tabatabai, Rebecca; Rushton, Priscilla S

doi:10.1016/0300-9629(84)90633-9

Cited by 12 publications

(6 citation statements)

References 27 publications

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“…Experimental data have documented time-dependent normal tissue toxicity and animal lethality after RT (25)(26)(27)(28)(29). Furthermore, the ability of radiation to generate apoptosis in rodent gut mucosa is time dependent (30)(31)(32).…”

Section: Introductionmentioning

confidence: 98%

Comparison of Toxicity Associated With Early Morning Versus Late Afternoon Radiotherapy in Patients With Head-and-Neck Cancer: A Prospective Randomized Trial of the National Cancer Institute of Canada Clinical Trials Group (HN3)

Bjarnason

MacKenzie

Nabid

et al. 2009

International Journal of Radiation Oncology*Biology*Physics

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Section: Introductionmentioning

confidence: 98%

Comparison of Toxicity Associated With Early Morning Versus Late Afternoon Radiotherapy in Patients With Head-and-Neck Cancer: A Prospective Randomized Trial of the National Cancer Institute of Canada Clinical Trials Group (HN3)

Bjarnason

MacKenzie

Nabid

et al. 2009

International Journal of Radiation Oncology*Biology*Physics

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“…Future studies evaluating the impact of time of day should employ statistical methods to rationally derive a time cut‐point. Moving forward, one potential solution for optimizing derivation of cut‐points would be combining our statistical analysis technique with molecular studies that identify circadian rhythm–based changes in radiation sensitivity pathways such as DNA damage repair …”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, multiple studies have demonstrated that mammalian cells vary in their sensitivity to radiation depending on their cell cycle phase, with cells in the G 2 /M phase demonstrating the greatest sensitivity to radiation‐induced damage . Murine tissues such as bone marrow and intestinal crypt cells have been shown to display variations in radiosensitivity throughout the day, with peak radiotherapy‐induced apoptosis occurring between 6:00 AM and 9:00 AM . In addition to rapidly proliferating cells such as bone marrow and intestinal crypt cells, the circadian rhythm–dependent radiosensitivity of tissues has also been shown to exist in slowly proliferating tissues such as the parotid gland .…”

Section: Introductionmentioning

confidence: 99%

Impact of time of day on outcomes after stereotactic radiosurgery for non–small cell lung cancer brain metastases

Badiyan

Ferraro

Yaddanapudi

et al. 2013

Cancer

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BACKGROUND: This study tested the hypothesis that time of day of treatment with stereotactic radiosurgery (SRS) has an effect on local control (LC) and overall survival (OS) in a large cohort of patients with non-small cell lung cancer (NSCLC) brain metastases. METHODS: At Washington University in St. Louis, 437 patients with NSCLC were treated with SRS for NSCLC brain metastases. Receiver operating characteristics analysis was used to identify an optimal cut-point for OS relative to time of day. Kaplan-Meier logrank statistics, and Cox regression univariate and multivariate analysis were employed to isolate any independent effect of treatment time on OS and LC. Matched-pair analysis was performed to isolate any independent effect of time on OS and LC of day while controlling for confounding variables. RESULTS: Receiver operating characteristics analysis identified a cut-point of 11:41 AM as providing the highest predictive value for OS. On univariate analysis, late SRS was associated with decreased OS, as was age, Karnofsky performance status, risk-stratification schemes, extracranial disease status, and overall burden of brain metastases. On univariate analysis for LC, late SRS was associated with decreased LC, as was burden of brain metastases. On multivariate analysis, only Graded Prognostic Assessment remained predictive of OS, and total number of targets and total tumor volume remained predictive of LC. Matched-pair analysis demonstrated no significant effect of time of day on LC or OS. CONCLUSIONS: Although earlier treatment appears to be associated with improved LC and OS, treatment time fails to remain significant when accounting for confounding variables. Cancer 2013;119:3563-9. V C 2013 American Cancer Society.KEYWORDS: Gamma Knife; radiosurgery; chronobiology; non-small cell lung cancer; circadian rhythm; time of day; survival; local control; brain metastases. INTRODUCTIONThe brain is one of the most common sites of metastases, occurring in 20% to 50% of patients with lung cancer. Multiple treatment options exist for the management of brain metastases, including surgery, whole-brain radiation therapy (WBRT), stereotactic radiosurgery, or combinations thereof. One-year local control (LC) after radiosurgery ranges from 67% to 90%.1-4 Established factors predicting for improved LC after radiosurgery include smaller tumor size, nonradioresistant histology, and the addition of WBRT.5-7 Predictors of overall survival (OS) include Recursive Partitioning Analysis (RPA), Score Index for Radiosurgery (SIR), and the newer Graded Prognostic Assessment (GPA) indices, which account for the effects of age, performance status, extracranial disease status, and now number of brain metastases and histology.

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“…Experimental data suggest that specific organ toxicity and animal lethality from radiotherapy is circadian time-dependent (64)(65)(66)(67)(68)(69). Studies also documented the time-dependent ability of radiation to generate apoptosis in gut mucosa (70)(71)(72).…”

Section: Discussionmentioning

confidence: 99%

Rhythms in Human Gastrointestinal Mucosa and Skin

Bjarnason

Jordan

2002

Chronobiology International

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Rhythmicity in cell proliferation is well established in the gastrointestinal tract and skin, both in rodents and humans. This is the basis for studies on the timing of both chemotherapy and radiotherapy. More recently, circadian rhythm studies of cell-cycle proteins have confirmed earlier findings based on thymidine labeling and flow cytometry. The genetic control of circadian rhythms has been elucidated recently and a possible connection between the circadian clock and the timing of cell-cycle events has been suggested. The data for gastrointestinal mucosa and skin are reviewed and the potential clinical implications of these results are discussed.

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Daily variation in radiosensitivity of circulating blood cells and bone marrow cellularity of mice

Cited by 12 publications

References 27 publications

Comparison of Toxicity Associated With Early Morning Versus Late Afternoon Radiotherapy in Patients With Head-and-Neck Cancer: A Prospective Randomized Trial of the National Cancer Institute of Canada Clinical Trials Group (HN3)

Comparison of Toxicity Associated With Early Morning Versus Late Afternoon Radiotherapy in Patients With Head-and-Neck Cancer: A Prospective Randomized Trial of the National Cancer Institute of Canada Clinical Trials Group (HN3)

Impact of time of day on outcomes after stereotactic radiosurgery for non–small cell lung cancer brain metastases

Rhythms in Human Gastrointestinal Mucosa and Skin

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