Daily Walking and the Risk of Knee Replacement Over 5 Years Among Adults With Advanced Knee Osteoarthritis in the United States

Master, Hiral; Thoma, Louise M.; Neogi, Tuhina; Dunlop, Dorothy D.; LaValley, Michael P.; Christiansen, Meredith B.; Voinier, Dana; White, Daniel K.

doi:10.1016/j.apmr.2021.05.014

Cited by 9 publications

(15 citation statements)

References 59 publications

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“…Our research shares many of the same arguments as numerous clinical studies. Master et al 37 found that walking not only did not increase the risk of knee replacement, but also significantly reduced the risk of joint replacement in KOA patients within 5 years. Similarly, Lo et al 38 believed that for KOA patients aged 50 years and above, walking exercise reduced the frequency of knee joint pain and had an effect on improving the disease, so they encouraged these patients to take walking exercise to alleviate their burdens.…”

Section: Discussionmentioning

confidence: 99%

Does Walking Have an Association with Osteoarthritis? A Two-Sample Mendelian Randomization Analysis

Xu,

Zhang,

Wang

et al. 2024

CIA

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Objective Osteoarthritis (OA) is one of the major disabling human diseases. The related studies indicate a potential correlation between walking and OA. However, there is still a lack of evidence in genetics to support the correlation between walking and OA. Therefore, this study aimed to explore the relationship between walking and OA at the genetic level. Methods The publicly available Genome Wide Association Study (GWAS) data were used, with inverse variance weighting (IVW, the random-effects model) as the main analysis method, whereas MR-Egger, Weighted median, Simple mode, and Weighted mode as the secondary analysis methods. In addition, Cochran’s Q test, pleiotropy test, and MR-Egger intercept test were conducted to examine the heterogeneity and pleiotropy of the outcome. Results In the MR analysis, IVW results showed a negative correlation between types of physical activity in last 4 weeks: Walking for pleasure (not as a means of transport) and OA (KOA or HOA) (odds ratio (OR) = 0.3224, 95% confidence interval (CI): 0.1261 to 0.8243), and the difference was of statistical significance (P = 0.0181). Moreover, IVW results also revealed a negative correlation between types of physical activity in last 4 weeks: Walking for pleasure (not as a means of transport) and KOA (OR = 0.1396, 95% CI: 0.0484 to 0.4026), and the difference was statistically significant (P = 0.0003). However, IVW results did not demonstrate any statistical significance types of physical activity in last 4 weeks: Walking for pleasure (not as a means of transport) and HOA (OR = 1.2075, 95% CI: 0.1978 to 7.3727, P = 0.8381). Conclusion From genetic studies, types of physical activity in last 4 weeks: Walking for pleasure (not as a means of transport) is negatively correlated with knee osteoarthritis (KOA), but there is no clear evidence supporting its correlation with hip osteoarthritis (HOA).

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Section: Discussionmentioning

confidence: 99%

Does Walking Have an Association with Osteoarthritis? A Two-Sample Mendelian Randomization Analysis

Xu,

Zhang,

Wang

et al. 2024

CIA

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“…As discussed above, exercise therapy seems not to have a detrimental effect on articular cartilage, but older studies have found conflicting evidence on the relationship between exercise therapy and risk of joint arthroplasty [ 30 – 36 ]. A recent study from the Osteoarthritis Initiative—a large prospective cohort study in the United States—investigating the association between walking (the most common form of exercise for patients with OA) and knee replacement in those with advanced disease found no increased risk of replacement surgery over 5 years [ 37 ]. Evidence of a protective effect against joint replacement was found with increased walking intensity (e.g.…”

Section: Is Exercise Therapy Safe For the Patient?mentioning

confidence: 99%

“…Evidence of a protective effect against joint replacement was found with increased walking intensity (e.g. 37% reduction in risk of surgery when replacing 10 min per day of light walking with moderating walking intensity) [ 37 ]. Another analysis from the Osteoarthritis Initiative found those who walk for exercise are less likely to report new frequent knee pain (40% decreased odds) and medial joint space narrowing progression (20% decreased odds) [ 38 ].…”

Section: Is Exercise Therapy Safe For the Patient?mentioning

confidence: 99%

Exercise Therapy for Knee and Hip Osteoarthritis: Is There An Ideal Prescription?

Young

Pedersen

2023

Curr Treat Options in Rheum

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Purpose of review Exercise therapy is the first line treatment for patients with knee and hip osteoarthritis (OA) but is consistently underutilized. In this review, we aim to provide health care professionals with an overview of the latest evidence in the areas of exercise therapy for OA, which can serve as a guide for incorporating the ideal exercise therapy prescription in the overall management plan for their patients with OA. Recent findings Evidence continues to be produced supporting the use of exercise therapy for all patients with knee or hip OA. Ample evidence exists suggesting exercise therapy is a safe form of treatment, for both joint structures and the patient overall. Several systematic reviews show that exercise therapy is likely to improve patient outcomes, regardless of disease severity or comorbidities. However, no single type of exercise therapy is superior to others. Summary Health care practitioners and patients should be encouraged to incorporate exercise therapy into treatment plans and can be assured of the safety profile and likelihood of improvement in important patient outcomes. Since no single exercise therapy program shows vastly superior benefit, patient preference and contextual factors should be central to the shared decision-making process when selecting and individualising appropriate exercise therapy prescriptions.

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“…There continues to be debate over appropriate activity levels with regard to both prevention and progression of knee osteoarthritis. In a prospective, multicenter, observational study, Master et al enrolled 516 adults with or at high risk for knee osteoarthritis 13 . In these subjects, higher daily walking volume and intensity did not increase the incidence of knee replacement over 5 years and demonstrated some protective effects.…”

Section: Kneementioning

confidence: 99%

What’s New in Orthopaedic Rehabilitation

Kasitinon

Williams

Gharib

et al. 2022

Journal of Bone and Joint Surgery

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Daily Walking and the Risk of Knee Replacement Over 5 Years Among Adults With Advanced Knee Osteoarthritis in the United States

Cited by 9 publications

References 59 publications

Does Walking Have an Association with Osteoarthritis? A Two-Sample Mendelian Randomization Analysis

Does Walking Have an Association with Osteoarthritis? A Two-Sample Mendelian Randomization Analysis

Exercise Therapy for Knee and Hip Osteoarthritis: Is There An Ideal Prescription?

What’s New in Orthopaedic Rehabilitation

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