Daily Work Stress and Awakening Cortisol in Mothers of Individuals with Autism Spectrum Disorders or Fragile X Syndrome

Wong, Jen D.; Mailick, Marsha R.; Greenberg, Jan S.; Hong, Jinkuk; Coe, Christopher L.

doi:10.1111/fare.12055

Cited by 17 publications

(17 citation statements)

References 53 publications

(82 reference statements)

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“…A few studies have contrasted parenting stress in mothers who have a child with autism and mothers whose child has FXS [17,112]. These studies generally have found similar patterns for premutation carrier mothers of children with FXS and mothers of those with autism.…”

Section: Reviewmentioning

confidence: 99%

Associated features in females with an FMR1 premutation

Wheeler

Bailey

Berry‐Kravis

et al. 2014

J Neurodevelop Disord

121

109

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Changes in the fragile X mental retardation 1 gene (FMR1) have been associated with specific phenotypes, most specifically those of fragile X syndrome (FXS), fragile X tremor/ataxia syndrome (FXTAS), and fragile X primary ovarian insufficiency (FXPOI). Evidence of increased risk for additional medical, psychiatric, and cognitive features and conditions is now known to exist for individuals with a premutation, although some features have been more thoroughly studied than others. This review highlights the literature on medical, reproductive, cognitive, and psychiatric features, primarily in females, that have been suggested to be associated with changes in the FMR1 gene. Based on this review, each feature is evaluated with regard to the strength of evidence of association with the premutation. Areas of need for additional focused research and possible intervention strategies are suggested.

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Section: Reviewmentioning

confidence: 99%

Associated features in females with an FMR1 premutation

Wheeler

Bailey

Berry‐Kravis

et al. 2014

J Neurodevelop Disord

121

109

View full text Add to dashboard Cite

show abstract

“…Notably, we went further in this examination by piecing together findings from studies that showed that a higher stress was associated with higher bedtime cortisol levels (Zoccola & Dickerson, 2015) with studies that showed that some of these same variables are associated with higher waking cortisol the following day (Wong et al, 2014). These data support our previous statement that exploring day-to-day transaction between psychosocial and physiologic effects may provide a new avenue for assessing CAR, and perhaps the cortisol diurnal rhythm in general.…”

Section: Discussionmentioning

confidence: 99%

“…However, the relationship between bedtime cortisol on one day and CAR the following day is rarely explored. Studies also suggest that previous days’ stressors are associated with higher bedtime cortisol (Zoccola & Dickerson, 2015) and the next morning’s cortisol levels (Wong et al, 2014), and that these higher waking cortisol levels are associated with flatter CAR slopes (Adam et al, 2006). …”

Section: Expanding the Time Frame For Assessing Predictors Of The Cormentioning

confidence: 99%

“…We used multinomial logistic regression to assess the likelihood of falling into one of the three CAR categories based on model predictors (Dmitrieva, Almeida, Dmitrieva, Loken, & Pieper, 2013). In our second analysis, we hypothesized that a path model would show that higher levels of bedtime cortisol would be associated with higher waking cortisol (Wong et al, 2014) and flatter CAR the next day (Dahlgren et al, 2009). …”

Section: Expanding the Time Frame For Assessing Predictors Of The Cormentioning

confidence: 99%

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Do psychosocial predictors affect the following days' cortisol awakening response? Expanding the temporal frame with which to explore morning cortisol

Proulx

Klee

Oken

2017

Stress

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Much of the extant cortisol awakening response (CAR) literature posits that CAR is an anticipatory response to perceived demands later that same day. However, expanding and switching the temporal order of cortisol and psychosocial influences may motivate more flexible approaches to understanding the dynamic relationship between mind and body, including cumulative strain on the HPA axis. This study was novel because we used two models to explore the effects of one day’s emotion regulation and cortisol levels on cortisol and CAR the following day in 100 mildly stressed adults aged 50–81 years old, which contrasts with the more common CAR-anticipatory-response design. In the first model, High negative-affect-variation on day 1 predicted a higher risk of having a flat CAR the next day, relative to the moderate-affect-variation group (RR = 10.10, p <.05). In the second model, higher bedtime cortisol on day 1 was positively associated with waking cortisol (β = .293, p <.01) and flatter CAR slopes on day 2 (β = −.422, p <.001). These results show that morning cortisol intercepts and slopes may be associated with previous days’ affect variability and levels of bedtime cortisol. These results also suggest that anticipation of demands may extend to the previous day, rather than just the morning of the demand, indicating a broader temporal framework for the study of CAR.

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“…Higher stress and negative emotions during a day are associated with lower morning cortisol awakening levels and lower CAR on the following day. There is, thus, a smaller difference between the morning cortisol level and the postawakening cortisol level (Proulx, Klee, & Oken, ; Wong et al, ). Having a sick child in need of medical care affects the parents’ mood (Angelhoff, Edéll‐Gustafsson, & Mörelius, ) and mothers have reported feeling less in control during accommodation at the paediatric ward (Angelhoff et al, ).…”

Section: Introductionmentioning

confidence: 99%

The cortisol response in parents staying with a sick child at hospital

2019

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Aim To study the cortisol response in parents staying with their child in paediatric wards, to compare the parents’ cortisol levels between the paediatric ward and at home 4 weeks after discharge and to compare the parents’ cortisol levels with data of an adult reference population, reported by Wust et al., as there are few studies investigating parental cortisol. Design This study has a descriptive and prospective comparative design. Method Thirty‐one parents participated. Saliva samples were collected in the paediatric ward and 4 weeks later at home. Results The parents had lower morning awakening cortisol levels in the paediatric ward than at home after discharge. There were no statistically significant differences in postawakening cortisol or cortisol awakening response (CAR). The child's age, diagnosis or previously diagnosed chronic condition did not affect the parents’ cortisol levels. The morning and postawakening cortisol levels were lower than those of the reference population. Conclusion The hospital stay with a sick child affects parents’ cortisol levels. Parental stress needs more attention to find interventions to prevent the risk of stress‐related complications that subsequently can affect the care of the child.

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Daily Work Stress and Awakening Cortisol in Mothers of Individuals with Autism Spectrum Disorders or Fragile X Syndrome

Cited by 17 publications

References 53 publications

Associated features in females with an FMR1 premutation

Associated features in females with an FMR1 premutation

Do psychosocial predictors affect the following days' cortisol awakening response? Expanding the temporal frame with which to explore morning cortisol

The cortisol response in parents staying with a sick child at hospital

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