Daldiconoids A-G: 3,4-Secolanostane triterpenoids from the fruiting bodies of Daldinia concentrica and their anti-inflammatory activity

Gong, Dingwei; Xie, Baoping; Sun, Yijun; Cheng, Yuanyuan; Tian, Xiaofei; Zhou, Zhengzheng; Tian, Li-Wen

doi:10.1016/j.phytochem.2024.114201

Phytochemistry

2024

DOI: 10.1016/j.phytochem.2024.114201

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Daldiconoids A-G: 3,4-Secolanostane triterpenoids from the fruiting bodies of Daldinia concentrica and their anti-inflammatory activity

Dingwei Gong,

Baoping Xie,

Yijun Sun

et al.

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2024

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Structures and Biological Activities of Secondary Metabolites from Daldinia spp.

Yu,

Chen,

Shi

et al. 2024

JoF

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The genus Daldinia have long been recognized as a source of structural novel, pharmaceutically relevant natural products. We reviewed the structures and activities of secondary metabolites isolated from the genus of Daldinia from January 1995 to June 2024, and 280 compounds, including six major categories—terpenoids, alkaloids, polyketides, polyphenols, steroids, and other classes—are presented in this review. Among these metabolites, 196 were identified as new structures. Remarkably, 112 compounds exhibited a range of biological activities, including cytotoxic, antimicrobial, anti-inflammatory, antifungal, anti-virus, and enzyme-inhibitory activities. This review highlights the bioactive metabolites discovered in the past three decades from the genus of Daldinia while also exploring the potential of these symbiotic fungi as rich sources of novel and diverse natural products. The varying bioactivities of these metabolites offer a vast array of promising lead compounds and also could significantly contribute to the development of new medicines.

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Structures and Biological Activities of Secondary Metabolites from Daldinia spp.

Yu,

Chen,

Shi

et al. 2024

JoF

View full text Add to dashboard Cite

show abstract

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Daldiconoids A-G: 3,4-Secolanostane triterpenoids from the fruiting bodies of Daldinia concentrica and their anti-inflammatory activity

Cited by 1 publication

References 28 publications

Structures and Biological Activities of Secondary Metabolites from Daldinia spp.

Structures and Biological Activities of Secondary Metabolites from Daldinia spp.

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