Dalfampridine effects on cognition, fatigue, and dexterity

Korsen, Melanie; Kunz, Rhina; Schminke, Ulf; Runge, Uwe; Kohlmann, Thomas; Dressel, Alexander

doi:10.1002/brb3.559

Cited by 18 publications

(12 citation statements)

References 31 publications

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“…Although no symptomatic treatment has provided adequate evidence for the treatment of cognitive dysfunction up to this point in time [ 84 ], preliminary data suggest a potential positive impact of fampridine in cognition and fatigue [ 85 , 86 ]. Furthermore, research regarding non pharmaceutical cognitive rehabilitation interventions has provided indications that MS patients may benefit cognitively [ 87 ].…”

Section: When To Measure and How To Deal With Findings?mentioning

confidence: 99%

The Rationale for Monitoring Cognitive Function in Multiple Sclerosis: Practical Issues for Clinicians

Bakirtzis

Ioannidis

Messinis

et al. 2018

TONEUJ

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About half of patients with multiple sclerosis exhibit cognitive impairment which negatively affects their quality of life. The assessment of cognitive function in routine clinical practice is still undervalued, although various tools have been proposed for this reason. In this article, we describe the potential benefits of implementing cognitive assessment tools in routine follow -ups of MS patients. Early detection of changes in cognitive performance may provide evidence of disease activity, could unmask depression or medication side-effects and provide suitable candidates for cognitive rehabilitation. Since apathy and cognitive deficiencies are common presenting symptoms in Progressive Multifocal Leukoencephalopathy, we discuss the utility of frequent monitoring of mental status in multiple sclerosis patients at increased risk. In addition, we propose a relevant algorithm aiming to incorporate a systematic evaluation of cognitive function in every day clinical practice in multiple sclerosis.

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Section: When To Measure and How To Deal With Findings?mentioning

confidence: 99%

The Rationale for Monitoring Cognitive Function in Multiple Sclerosis: Practical Issues for Clinicians

Bakirtzis

Ioannidis

Messinis

et al. 2018

TONEUJ

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“…Accordingly, many studies have focused on the development of drugs or therapies with respect to fatigue (24,25). In addition, considering the limitations of available therapies for fatigue in modern medicine, potential alternatives from traditional medicine are worth investing because of their safety, availability, and ease of administration (26).…”

Section: Introductionmentioning

confidence: 99%

Nigella sativa seed extract attenuates the fatigue induced by exhaustive swimming in rats

Rahman

Yang

Kim³

et al. 2017

Biomedical Reports

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Abstract. In previous studies, Nigella sativa (NS) has been studied due to its various physiological and pharmacological activities. However, evidence on the effects of NS on physical fatigue following exhaustive swimming remains limited. In the present study, the authors evaluated the potential beneficial effects of NS against the fatigue activity following exhaustive swimming. Rats were orally administered with NS extract (2 g/kg/day) for 21 days, and the anti-fatigue effect was assessed by exhaustive swimming exercise. The presented results indicated that pre-treatment of NS extract significantly increased the time to exhaustion. In hemodynamic parameters, NS extract increased blood pO 2 and O 2sat , but decreased pCO 2 . For underlying mechanisms, NS extract protected depletion of energy, indicated by increased levels of blood pH, glucose and tissue glycogen contents, and decreased levels of blood lactate, tissue lactic dehydrogenase and creatine kinase, when the NS extract was pre-treated. In addition, the NS extract inhibited oxidative stress following exhaustive swimming, as reflected by the results of increased levels of superoxide dismutase and redox ratio, and decreased the level of malondialdehyde when the NS extract was pre-treated. Collectively, the present study demonstrated that NS extract has an anti-fatigue activity against exhaustive swimming by energy restoration and oxidative-stress defense.

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“…By magnifying the axonal conductance, this potassium channel inhibitor is used in MS patients to improve cognition, fatigue, and dexterity [ 195 ]. In a randomized, double-blind, placebo-controlled crossover study of dalfampridine in transverse myelitis patients, intervention improved walking speed and other neurological functions [ 113 ].…”

Section: Current and Evolving Therapeutic Strategies In Nmosdmentioning

confidence: 99%

B Cells and Antibodies as Targets of Therapeutic Intervention in Neuromyelitis Optica Spectrum Disorders

Traub¹,

Husseini

Weber

2021

Pharmaceuticals

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The first description of neuromyelitis optica by Eugène Devic and Fernand Gault dates back to the 19th century, but only the discovery of aquaporin-4 autoantibodies in a major subset of affected patients in 2004 led to a fundamentally revised disease concept: Neuromyelits optica spectrum disorders (NMOSD) are now considered autoantibody-mediated autoimmune diseases, bringing the pivotal pathogenetic role of B cells and plasma cells into focus. Not long ago, there was no approved medication for this deleterious disease and off-label therapies were the only treatment options for affected patients. Within the last years, there has been a tremendous development of novel therapies with diverse treatment strategies: immunosuppression, B cell depletion, complement factor antagonism and interleukin-6 receptor blockage were shown to be effective and promising therapeutic interventions. This has led to the long-expected official approval of eculizumab in 2019 and inebilizumab in 2020. In this article, we review current pathogenetic concepts in NMOSD with a focus on the role of B cells and autoantibodies as major contributors to the propagation of these diseases. Lastly, by highlighting promising experimental and future treatment options, we aim to round up the current state of knowledge on the therapeutic arsenal in NMOSD.

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Dalfampridine effects on cognition, fatigue, and dexterity

Cited by 18 publications

References 31 publications

The Rationale for Monitoring Cognitive Function in Multiple Sclerosis: Practical Issues for Clinicians

The Rationale for Monitoring Cognitive Function in Multiple Sclerosis: Practical Issues for Clinicians

Nigella sativa seed extract attenuates the fatigue induced by exhaustive swimming in rats

B Cells and Antibodies as Targets of Therapeutic Intervention in Neuromyelitis Optica Spectrum Disorders

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