Dalitong Granule (达立通颗粒) combined with electroacupuncture in the treatment of functional dyspepsia: A randomized controlled trial

Zhang, Chaoxian; Guo, Like

doi:10.1007/s11655-015-2175-5

Cited by 19 publications

(50 citation statements)

References 11 publications

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“…Previously, most herbal trials were performed with open-labeled methods. [ 20 21 22 23 ] In the present study, we designed the placebo, which contained 5% of the active ingredient of the medicine, to have a similar taste, appearance, and smell without having a pharmacologically active effect. In the recruitment period, the patients who positively reacted to the placebo were excluded, which could effectively avoid the placebo effect.…”

Section: Discussionmentioning

confidence: 99%

A Randomized, Double-Blind, Multicenter, Placebo-Controlled Trial of Qi-Zhi-Wei-Tong Granules on Postprandial Distress Syndrome-Predominant Functional Dyspepsia

Chen

Wang

et al. 2018

Chinese Medical Journal

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Background:Functional dyspepsia (FD) is a common upper gastrointestinal disorder worldwide, but the current treatments for FD are still unsatisfactory. The aims of this study were to investigate the efficacy and safety of Qi-Zhi-Wei-Tong granules in patients with postprandial distress syndrome (PDS)-predominant FD.Methods:The study was conducted as a randomized, double-blinded, multicenter, placebo-controlled design in 197 patients with PDS. All participants received placebo treatment for 1 week. Patients whose total symptom score decreased by <50% after the placebo treatment were recruited into the 4-week treatment period, in which they were randomly assigned to be treated with either Qi-Zhi-Wei-Tong granules or placebo. The patients were then followed for 2 weeks without any treatment. Dyspeptic symptoms were scored at weeks 2 and 4 during the random treatment period and 2 weeks after the treatment. Anxiety and depression symptoms were also scored and compared.Results:(1) The total effective rates in the Qi-Zhi-Wei-Tong granules group at weeks 2 and 4 during the random treatment period and 2 weeks after treatment were all significantly higher than those in the placebo group (38.82% vs. 8.75%, P < 0.001; 69.14% vs. 16.25%, P < 0.001; 77.65% vs. 21.25%, P < 0.001). (2) The total dyspeptic symptoms scores in the Qi-Zhi-Wei-Tong granules group at weeks 2 and 4 and 2 weeks after treatment were significantly lower than those in the placebo group. (3) The severity and frequency of each dyspeptic symptom at weeks 2 and 4 and the follow-up period were all significantly lower than those in the placebo group. (4) The anxiety scores in the Qi-Zhi-Wei-Tong granules group were significantly lower than those in the placebo group. (5) Qi-Zhi-Wei-Tong granules did not have more adverse effects than the placebo.Conclusion:Qi-Zhi-Wei-Tong granules offer significant symptomatic improvement in PDS with no more adverse effects than placebo.Trial Registration:https://clinicaltrials.gov/, NCT02460601.

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Section: Discussionmentioning

confidence: 99%

A Randomized, Double-Blind, Multicenter, Placebo-Controlled Trial of Qi-Zhi-Wei-Tong Granules on Postprandial Distress Syndrome-Predominant Functional Dyspepsia

Chen

Wang

et al. 2018

Chinese Medical Journal

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“…All articles included in the analysis were designed as randomized clinical trial studies. Five studies [ 12 – 15 , 17 ] used random number tables or lists, while the others did not detail the specific methods of randomization. An attempt to contact the authors to clarify the method did not generate any responses.…”

Section: Resultsmentioning

confidence: 99%

“…There was 3 sham intervention (sham-EA) [ 12 , 13 , 16 ] in the included studies and participant blinding was deemed to be applicable. Three trials [ 13 – 15 ] reported dropout rates of patients. All trials reported all outcome measurements mentioned in the methods and were therefore deemed to be at low risk of attrition bias.…”

Section: Resultsmentioning

confidence: 99%

Electroacupuncture for the treatment of functional dyspepsia

Mao

Guo

et al. 2020

Medicine

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Background: Functional dyspepsia (FD) is a common functional gastrointestinal disease. Acupuncture, including electroacupuncture (EA) is widely used as a complementary and alternative treatment for patients with FD. This study aimed to explore the effectiveness of EA for the treatment of FD. Methods: We searched Embase, PubMed, and the Cochrane Central Register of Controlled Trials (Cochrane Library) for randomized controlled trials of FD treated by EA from inception to February 3, 2020. Two reviewers will independently screen studies for data extraction and assess the quality and risk of bias. The Cochrane Collaboration's risk of bias tool, RevMan 5.3 software were used for meta-analysis. Data were pooled to calculate relative risk and 95% confidence intervals (CIs) of substantial improvement after treatment for dichotomous data and mean differences (SMDs) and 95% CIs for continuous data. Results: Seven randomized clinical trials included 853 patients. This meta-analysis investigated the effectiveness of EA alone in the treatment of FD relative to sham-EA or pharmacologic medication (PM). The results showed that EA could significantly improve clinical symptoms. Compared with sham-EA, EA was more effective in reducing symptom scores (SMD −3.44, 95% CI −4.21 to −2.67) and increasing normal slow waves of electrogastrogram (SMD 0.93, 95% CI −0.30 to1.55). When EA was combined with PM, there was no significant difference in reducing symptom scores (SMD −0.18, 95% CI −0.51 to 0.16), increasing the effective rate of clinical symptoms (risk ratio 1.04, 95% CI 0.96 to 1.13), enhancing the level of plasma motilin (SMD 0.93, 95% CI −0.30 to1.55), and reducing gastric half-emptying time (SMD 0.02, 95% CI −0.16 to 0.20). The results also showed that there were very few adverse events reported. Conclusion: This meta-analysis suggests that EA is better than the placebo (sham-EA) in treating FD, and the therapeutic effect of EA on FD is equivalent to that of PM on FD. Compared with PM, EA for FD is safer and has fewer adverse reactions. Despite limitations due to the quality and number of the included studies, EA might be used as an effective and safe treatment for FD.

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“…Fang et al [88] found that acupuncture relieved gastrointestinal symptoms and signs using resting-state fMRI, which may be due to the normalization of brain-gut axis in FD patients. (3) Molecular mechanism: A study performed by Zhang and Guo showed that EA increased plasma motilin, thereby promoting gastric emptying and alleviating the symptom of dyspepsia [89]. (4) Metabolomics mechanisms: Li et al [90] found that stimulation of different acupoints regulates the plasma levels of markers of FD as revealed by high performance liquid chromatography-mass spectrometry combined with metabolomics.…”

Section: Discussionmentioning

confidence: 99%

Efficacy Comparison of Different Acupuncture Treatments for Functional Dyspepsia: A Systematic Review with Network Meta‐Analysis

Zhang

Liu

Huang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Background. Acupuncture has been found to be an effective treatment for functional dyspepsia (FD). Currently, several types of acupuncture have been developed but it is not clear which type is suitable for FD. Currently, doctors often rely on experience to decide which form of acupuncture to apply. Herein, we employed network meta-analysis (NMA) to compare the effectiveness of various methods of acupuncture in the treatment of functional dyspepsia. Methods. We searched for randomized controlled trials (RCTs) of acupuncture treatments for functional dyspepsia in seven databases; PubMed, the Cochrane Library, Embase, Wanfang database, China National Knowledge Infrastructure (CNKI) database, Chinese Science and Technique Journals (CQVIP), and Chinese Biomedical Database (CBM) from the date of database inception to October 10, 2019. Cochrane risk of bias tool was used to analyze the risk of bias of the included RCTs. Pairwise meta-analyses were performed with RevMan 5.3 and the network metaanalysis of the included RCTs was performed using the frequentist framework. Results. A total of 35 studies involving 3301 patients and 10 interventions were eligible for this study. NMA results showed that five types of acupuncture (manual acupuncture, acupoint application, moxibustion, acupoint catgut embedding, and warm acupuncture alone) all were superior to prokinetics (itopride, mosapride, and domperidone) and sham acupuncture in terms of improving the symptoms of functional dyspepsia. Specifically, manual acupuncture and electroacupuncture were more effective in improving the MOS 36 Item Short-Form Health Survey (SF-36) compared to itopride and sham acupuncture, and electroacupuncture was the best among the three acupuncture therapies (acupuncture, electroacupuncture, and acupoint catgut embedding). Moxibustion and manual acupuncture were more effective in improving Nepean Dyspepsia Life Quality Index (NDLQI) compared to itopride, domperidone, and sham acupuncture; moxibustion ranks first among the three acupuncture therapies (acupuncture, electroacupuncture, moxibustion). Conclusions. ese results showed that manual acupuncture alone was the most effective therapy for FD. It should, therefore, be considered as an alternative treatment for FD patients who are unresponsive to prokinetics or intolerant to the adverse effects of prokinetics. We recommend further multiple centers and high-quality RCT studies to confirm the present findings.

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Dalitong Granule (达立通颗粒) combined with electroacupuncture in the treatment of functional dyspepsia: A randomized controlled trial

Abstract: Combined treatment of DG and EA could increase both plasma motilin and electrogastrographic frequencies, promote gastric emptying, alleviate the symptom of dyspepsia so as to increase quality of life, with better safety and long-term effect.

Cited by 19 publications

References 11 publications

A Randomized, Double-Blind, Multicenter, Placebo-Controlled Trial of Qi-Zhi-Wei-Tong Granules on Postprandial Distress Syndrome-Predominant Functional Dyspepsia

A Randomized, Double-Blind, Multicenter, Placebo-Controlled Trial of Qi-Zhi-Wei-Tong Granules on Postprandial Distress Syndrome-Predominant Functional Dyspepsia

Electroacupuncture for the treatment of functional dyspepsia

Efficacy Comparison of Different Acupuncture Treatments for Functional Dyspepsia: A Systematic Review with Network Meta‐Analysis

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