Dall’andalusia Al Nuovo Mondo:

Orlandi, Angela

doi:10.2307/j.ctt1tqx87n.6

Cited by 3 publications

(4 citation statements)

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“…Alterations in BM cytokine expression by long-term T1D in mice was also reported by Orlandi et al [46], who found increased levels of insulin-like growth factor-1 and insulin-like growth factor binding protein 5, osteoprotegerin, and VEGF. Together with reduced expression of the Bmi1 gene, which prevents HSPC senescence, these changes might be responsible for the impaired repopulation capacity of the diabetic BM stem cell niche [46]. Defective repopulation and recovery after challenge with 59-FU have also been reported by Westerweel et al [49] in T1D mice.…”

Section: Mechanisms Of Bone Marrow Damage and Dysfunction In Diabetessupporting

confidence: 77%

“…Interestingly, gp130 2/2 mice, which are less responsive to inflammatory cytokines, were protected from BM dysfunction induced by diabetes [31]. Alterations in BM cytokine expression by long-term T1D in mice was also reported by Orlandi et al [46], who found increased levels of insulin-like growth factor-1 and insulin-like growth factor binding protein 5, osteoprotegerin, and VEGF. Together with reduced expression of the Bmi1 gene, which prevents HSPC senescence, these changes might be responsible for the impaired repopulation capacity of the diabetic BM stem cell niche [46].…”

Section: Mechanisms Of Bone Marrow Damage and Dysfunction In Diabetessupporting

confidence: 62%

“…This mobilopathy cannot be simply attributed to a reduction in the number of intramarrow cells available for mobilization. In animal models of diabetes, the number of BM stem cells was found to be decreased [46], unaffected [43], or even increased [11], according to diabetes model, type, and duration. In humans, BM CD34 + stem cells are reduced [33,34], but defective mobilization takes place before baseline circulating stem cell levels decline [42].…”

Section: The Diabetic Stem Cell Mobilopathymentioning

confidence: 97%

“…Similarly, potentiating the residual sympathetic output with norepinephrin reuptake inhibitors might be a valuable strategy to counter BM dysfunction and impaired vascular recovery induced by diabetic neuropathy [38]. Based on the prominent role played by innate immunity in BM niche regulation and on the proinflammatory pathways activated in the diabetic BM [34,46], it can also be anticipated that anti-inflammatory therapies can have beneficial effects, but no data are so far available in support of this hypothesis.…”

Section: Consequences and Therapeutic Implications Of Bm Dysfunction mentioning

confidence: 99%

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Concise Review: Diabetes, the Bone Marrow Niche, and Impaired Vascular Regeneration

Fadini

Ferraro

Quaini

et al. 2014

Stem Cells Translational Medicine

102

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Diabetes mellitus is a global health problem that results in multiorgan complications leading to high morbidity and mortality. Until recently, the effects of diabetes and hyperglycemia on the bone marrow microenvironment-a site where multiple organ systems converge and communicate-have been underappreciated. However, several new studies in mice, rats, and humans reveal that diabetes leads to multiple bone marrow microenvironmental defects, such as small vessel disease (microangiopathy), nerve terminal pauperization (neuropathy), and impaired stem cell mobilization (mobilopathy). The discovery that diabetes involves bone marrow-derived progenitors implicated in maintaining cardiovascular homeostasis has been proposed as a bridging mechanism between microand macroangiopathy in distant organs. Herein, we review the physiological and molecular bone marrow abnormalities associated with diabetes and discuss how bone marrow dysfunction represents a potential root for the development of the multiorgan failure characteristic of advanced diabetes. The notion of diabetes as a bone marrow and stem cell disease opens new avenues for therapeutic interventions ultimately aimed at improving the outcome of diabetic patients. STEM CELLS TRANSLATIONAL MEDICINE 2014;3:949-957

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Section: Mechanisms Of Bone Marrow Damage and Dysfunction In Diabetessupporting

confidence: 77%

Section: Mechanisms Of Bone Marrow Damage and Dysfunction In Diabetessupporting

confidence: 62%

Section: The Diabetic Stem Cell Mobilopathymentioning

confidence: 97%

Section: Consequences and Therapeutic Implications Of Bm Dysfunction mentioning

confidence: 99%

See 2 more Smart Citations

Concise Review: Diabetes, the Bone Marrow Niche, and Impaired Vascular Regeneration

Fadini

Ferraro

Quaini

et al. 2014

Stem Cells Translational Medicine

102

View full text Add to dashboard Cite

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Tuscan merchants in Andalusia: a historiographical debate

Orlandi

2016

European Review of History: Revue européenne d'histoire

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Denaro, cultura, bellezza

Orlandi

2024

Biblioteca Di Storia

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The history of the Botti is both family biography and an account of a Florentine company that was present on the most important economic markets of the first half of the sixteenth century (Florence, Pisa, Cádiz, Seville, Venice, Valladolid, Rome, Antwerp and Lyon). Their enduring commercial activity abroad and the intensity of their economic relations beyond their home city fostered encounters of different cultures. They were protagonists of an intercultural exchange which on the strength of a solid foundation of money and finance spread the taste for beauty and Florentine Renaissance culture. They contributed to the realisation of the ‘Florence factor’, which is held to be the precursor of the ‘Italy factor’, namely the ability to produce attractive things appreciated throughout the world. Not only did the Botti family use their wealth, artistic taste and culture to grow economically, they also played a role in making their city an essential point of reference for the Italian Renaissance, thus benefiting artists as well. Their commercial earnings allowed them to assemble a splendid collection of artworks, which the last member of the family, Matteo di Giovanbattista, left to the Medici; these works included Raphael’s La Velata, reproduced here on the cover.

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Dall’andalusia Al Nuovo Mondo:

Cited by 3 publications

References 0 publications

Concise Review: Diabetes, the Bone Marrow Niche, and Impaired Vascular Regeneration

Concise Review: Diabetes, the Bone Marrow Niche, and Impaired Vascular Regeneration

Tuscan merchants in Andalusia: a historiographical debate

Denaro, cultura, bellezza

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