“…In terms of coumarin concentration, obtained after hydroalcoholic extraction of guaco leaves, it was reported that lyophilization results in a higher coumarin content, 17.7 mg/g, than that obtained after pre-treatment with spray dryer, 8.0 mg/g (E Silva et al, 2012). Furthermore, the coumarin contents obtained after drying in an oven at 40 °C are higher than those obtained from leaves dried in the shade (Borghi et al, 2019). For pre-drying at 50 and 60 °C, the temperature harmed the concentration of coumarin in the extract (Silva et al, 2018).…”