Damage effects of dust storm PM2.5 on DNA in alveolar macrophages and lung cells of rats

Meng, Ziqiang; Zhang, Quanxi

doi:10.1016/j.fct.2007.01.014

Cited by 52 publications

(26 citation statements)

References 35 publications

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“…Oxidative DNA damage in lung cells has been extensively reported in in vitro and in vivo systems exposed to PM or UFPs (Gualtieri et al, 2012;Longhin et al, 2013;Meng and Zhang, 2007;Oh et al, 2011). Pb, a prevalent toxic metal component in ambient PM, is known to induce oxidative stress and oxidative DNA damage.…”

Section: Discussionmentioning

confidence: 99%

Combined exposure to nano-silica and lead induced potentiation of oxidative stress and DNA damage in human lung epithelial cells

Yuan

et al. 2015

Ecotoxicology and Environmental Safety

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Section: Discussionmentioning

confidence: 99%

Combined exposure to nano-silica and lead induced potentiation of oxidative stress and DNA damage in human lung epithelial cells

Yuan

et al. 2015

Ecotoxicology and Environmental Safety

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“…It is widely accepted that desert dust has the capacity to (1) cause damage to the alveolar walls and bronchial epithelial cells through a direct physical effect; (2) influence oxidative stress and release of pro-inflammatory cytokines in respiratory epithelial cells; (3) damage DNA (the organic compounds and the insoluble particle-core might be the main contributors to DNA damage) [157]; and (4) cause a deterioration in pulmonary function. …”

Section: Pathogeny Of Desert Dust On Respiratory Diseasesmentioning

confidence: 99%

A Systematic Review of Global Desert Dust and Associated Human Health Effects

et al. 2016

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Dust storms and sandy dust events originating in arid and semi-arid areas can transport particulate material, pollutants, and potential transport long distances from their sources. Exposure to desert dust particles is generally acknowledged to endanger human health. However, most studies have examined anthropogenic particulate sources, with few studies considering contributions from natural desert dust. A systematic literature review was undertaken using the ISI Web of Knowledge and PubMed databases with the objective of identifying all studies presenting results on the potential health impact from desert dust particles across the world. This review reveals an imbalance between the areas most exposed to dust and the areas most studied in terms of health effects. Among the human health effects of dust storms are mortality and morbidity, arising from respiratory system, circulatory system, and other diseases. We summarize the quantitative results of current scientific health research and possible pathological mechanisms, and describe some of the many challenges related to understanding health effects from exposures to desert dust particles. Overall, for respiratory and circulatory mortality, both positive and negative associations have been reported for PM 10 of desert dust, but only a positive relationship was reported between PM 2.5-10 and mortality, and a positive relationship was also reported between PM 2.5 and human mortality. Future pathological studies should continue to focus on those mechanisms causing the most harmful effect of desert dust on respiratory and cardiovascular diseases. More attention should also be paid to the association between desert dust and the morbidity of other diseases, such as those affecting the reproductive system and nervous system.

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“…in addition, these pathogens can adhere to the outer surface of the dust particles that can stimulate the biological immune-responses in human body. The pathogenic bacteria such as Bacillus cereus, Bacillus anthracis, Campylobacter jejuni, Escherichia coli, Listeria monocytogenes, Salmonella typhimurium, Shigella spp., Staphylococcus aureus, and Staphylococcal enteritis are dominantly detectable within 10 3 to 10 5 cell/m 3 in asian dust subsided, which are able to infect and harm humans 56 . a large number of antibody based biosensing methods were examined in "affinity" biosensors with excellent sensitivity and selectivity for pathogenic bacteria and other harmful elements.…”

Section: Perspectivesmentioning

confidence: 99%

Toxicoproteomic approaches for analysis of microbial community inhabiting Asian dust particles

Sekhon

Ahn

Min

et al. 2015

Mol. Cell. Toxicol.

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in this review, we provide an overview of the bio-analytical approaches for proteomic analysis of asian dust storms. asian dust has been known to travel with high-speed eastward winds and affects air quality over Japan and even the western coast of the U.S. during severe occurrences. Several reports have shown that asian dust particles have a negative effect on a wide range of industries and human health activities. Here we give a short overview of asian dust feature and its proteomic analysis approaches including 2-De PaGe, metaproteomic analysis of large environmental samples, and automatic techniques for dust microbial analysis. Following this, we discuss the detection system of asian dust particles that can be integrated with biosensor platform.

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Damage effects of dust storm PM2.5 on DNA in alveolar macrophages and lung cells of rats

Cited by 52 publications

References 35 publications

Combined exposure to nano-silica and lead induced potentiation of oxidative stress and DNA damage in human lung epithelial cells

Combined exposure to nano-silica and lead induced potentiation of oxidative stress and DNA damage in human lung epithelial cells

A Systematic Review of Global Desert Dust and Associated Human Health Effects

Toxicoproteomic approaches for analysis of microbial community inhabiting Asian dust particles

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