Structural health monitoring is an important aspect of maintenance for bridge columns in areas of high seismic activity. In this project, recently developed piezoceramic-based transducers, known as smart aggregates (SA), were utilized to perform structural health monitoring of a reinforced concrete (RC) bridge column subjected to pseudo-dynamic loading. The SA-based approach has been previously verified for static and dynamic loading but never for pseudo-dynamic loading. Based on the developed SAs, an active-sensing approach was developed to perform real-time health status evaluation of the RC column during the loading procedure. The existence of cracks attenuated the stress wave transmission energy during the loading procedure and reduced the amplitudes of the signal received by SA sensors. To detect the crack evolution and evaluate the damage severity, a wavelet packet-based structural damage index was developed. Experimental results verified the effectiveness of the SAs in structural health monitoring of the RC column under pseudo-dynamic loading. In addition to monitoring the general severity of the damage, the local structural damage indices show potential to report the cyclic crack open-close phenomenon subjected to the pseudo-dynamic loading.