Damage-free evaluation of cultured cells based on multivariate analysis with a single-polymer probe

Abstract

We present a pattern-recognition-based sensor that targets cell-derived components in culture media and evaluates cultured cells without damaging them. An array sensor made of a single-polymer probe was employed to...

Peptomer substrates for quantitative pattern-recognition sensing of proteases

“…Pattern-recognition sensing, an approach that relies on the cross-reactivity of multiple probes to sense diverse analytes, has gained popularity for sensing biomarkers over the past two decades as researchers shifted from designing for specificity to engineering differential capacity. 1 Sensing targets have included small species like volatile organic compounds, 2 metal ions, [3][4][5][6] and individual amino acids [7][8][9] all the way up to proteins 10,11 and cells themselves, [12][13][14][15] as well as combinations of multiple components. 16,17 Enzymes are often regarded as analytes that fit into the ''lock-and-key'' category of specific sensing.…”