Damage mechanisms for ultrasound-induced cavitation in tissue

Warnez, Matthew; Vlaisavljevich, Eli; Xu, Zhen; Johnsen, Eric

doi:10.1063/1.4977634

Cited by 4 publications

(4 citation statements)

References 22 publications

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“…Conventionally, relevant investigations in acousticassisted drug delivery have employed the microbubbles consisting of gases and lipids [25,57]. Although the gasphase microbubbles could lyse the blood clots by dispersing cavitational energy into the surrounding bloodstream, this might provide the surrounding tissues with high rarefactional pressures or locally increased temperature [58]. Therefore, recent studies have attempted to develop more stable and homogeneous particles using amphiphilic polymeric substances, showing polymeric micelles and hybrid-based microbubbles [59].…”

Section: Discussionmentioning

confidence: 99%

Targeted thrombolysis by magnetoacoustic particles in photothrombotic stroke model

et al. 2022

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Background Recombinant tissue plasminogen activator (rtPA) has a short half-life, and additional hemorrhagic transformation (HT) can occur when treatment is delayed. Here, we report the design and thrombolytic performance of 3 $$\upmu$$ μ m discoidal polymeric particles loaded with rtPA and superparamagnetic iron oxide nanoparticles (SPIONs), referred to as rmDPPs, to address the HT issues of rtPA. Methods The rmDPPs consisted of a biodegradable polymeric matrix, rtPA, and SPIONs and were synthesized via a top-down fabrication. Results The rmDPPs could be concentrated at the target site with magnetic attraction, and then the rtPA could be released under acoustic stimulus. Therefore, we named that the particles had magnetoacoustic properties. For the in vitro blood clot lysis, the rmDPPs with magnetoacoustic stimuli could not enhance the lytic potential compared to the rmDPPs without stimulation. Furthermore, although the reduction of the infarcts in vivo was observed along with the magnetoacoustic stimuli in the rmDPPs, more enhancement was not achieved in comparison with the rtPA. A notable advantage of rmDPPs was shown in delayed administration of rmDPPs at poststroke. The late treatment of rmDPPs with magnetoacoustic stimuli could reduce the infarcts and lead to no additional HT issues, while rtPA alone could not show any favorable prognosis. Conclusion The rmDPPs may be advantageous in delayed treatment of thrombotic patients.

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Section: Discussionmentioning

confidence: 99%

Targeted thrombolysis by magnetoacoustic particles in photothrombotic stroke model

et al. 2022

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“…The ideal method of cancer treatment is to remove local tumors without damaging normal tissues, and to activate the whole body's anti-tumor immune response 161 . In recent years, many exciting research results have been achieved in the field of tumor immunotherapy, which bring great hope for the advanced or terminal cancer patient 162 . Due to the high degree of heterogeneity and specificity of the human immune system, current immunotherapy is not perfect yet, and cannot be commonly applied in clinical treatment 163,164 .…”

Section: Discussionmentioning

confidence: 99%

“…However, the high-temperature HIFU is more effective for tumor ablation and curing primary diseases, so the advantages and disadvantages of tumor ablation and immunotherapy should be carefully weighed when using HIFU. In addition, as a carrier of genes or antigens in immunotherapy, microbubbles are also complicated to prepare with full consideration of the half-life and penetration efficiency of carriers 162 . It is undeniable that with the gradual thorough research on the mechanisms of immunotherapy, HIFU ablation, microbubble-mediated drug delivery and other mechanisms, the combined treatment of US and immunotherapy has a very broad prospect.…”

Section: Discussionmentioning

confidence: 99%

Low-frequency HIFU induced cancer immunotherapy: tempting challenges and potential opportunities

et al. 2019

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Immunotherapy is playing an increasingly important role in the treatment of tumors. Different from the traditional direct killing or excision therapies, immunotherapy depends on autologous immunity to kill tumor cells and tissues by activating or enhancing the bodys immune system. Large numbers of recent studies suggest that low-frequency HIFU can not only enhance the intensity of the bodys anti-cancer immune response, but also improve the efficiency of immunotherapy drug delivery to strengthen the effects of tumor immunotherapy. The focused ultrasound (FUS) destructs the tumor and simultaneously generates tumor debris and tumor-associated antigens, which enhances the immunogenicity of the tumor and stimulates the immune cells, inducing the bodys immune response. Microbubbles are clinically used as a contrast. As a matter of fact, the addition of microbubbles can reinforce the destructive effect of FUS on the tumor and activate a stronger immune response. The combined application of ultrasound and microbubbles can more effectively open the blood brain barrier (BBB), which is beneficial to improving the intake of immune cells or immunotherapy drugs and exerting a positive influence in the lesion area. Currently, microbubbles and nanoparticles are commonly used as gene and drug carriers. Using ultrasound, the immune-related gene or antigen delivery itself can enhance the immune response and improve the efficacy of the immunotherapy.

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“…When the sono-active compound gets to the cell, ultrasound treatment induces implosion and sonoluminescent light emission ( 239 – 241 ). Moreover, the collection of diffused gases leads to forming a high-volume gas bubble in a process called cavitation ( 242 ).…”

Section: Physical Methods and Their Mechanismsmentioning

confidence: 99%

Chemotherapy and Physical Therapeutics Modulate Antigens on Cancer Cells

et al. 2022

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Cancer cells possess specific properties, such as multidrug resistance or unlimited proliferation potential, due to the presence of specific proteins on their cell membranes. The release of proliferation-related proteins from the membrane can evoke a loss of adaptive ability in cancer cells and thus enhance the effects of anticancer therapy. The upregulation of cancer-specific membrane antigens results in a better outcome of immunotherapy. Moreover, cytotoxic T-cells may also become more effective when stimulated ex-vivo toward the anticancer response. Therefore, the modulation of membrane proteins may serve as an interesting attempt in anticancer therapy. The presence of membrane antigens relies on various physical factors such as temperature, exposure to radiation, or drugs. Therefore, changing the tumor microenvironment conditions may lead to cancer cells becoming sensitized to subsequent therapy. This paper focuses on the therapeutic approaches modulating membrane antigens and enzymes in anticancer therapy. It aims to analyze the possible methods for modulating the antigens, such as pharmacological treatment, electric field treatment, photodynamic reaction, treatment with magnetic field or X-ray radiation. Besides, an overview of the effects of chemotherapy and immunotherapy on the immunophenotype of cancer cells is presented. Finally, the authors review the clinical trials that involved the modulation of cell immunophenotype in anticancer therapy.

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Damage mechanisms for ultrasound-induced cavitation in tissue

Cited by 4 publications

References 22 publications

Targeted thrombolysis by magnetoacoustic particles in photothrombotic stroke model

Targeted thrombolysis by magnetoacoustic particles in photothrombotic stroke model

Low-frequency HIFU induced cancer immunotherapy: tempting challenges and potential opportunities

Chemotherapy and Physical Therapeutics Modulate Antigens on Cancer Cells

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