Damage of nasal mucociliary movement after intensity-modulated radiation therapy of nasopharyngeal carcinoma

Yin, Gendi; Xiong, Guanxia; Zhao, Chong; Chen, Yuanyuan

doi:10.5732/cjc.010.10067

Cited by 16 publications

(20 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Palme et al also demonstrated that radiotherapy was the major factor influencing quality of life for patients with anterior skull base neoplasms treated with both open and endoscopic approaches (11) . From the literature on the management of nasopharyngeal carcinoma, radiotherapy can have effects on both local function (15) and cognitive function (16) .…”

Section: The Influence Of Olfactory Apparatus Removalmentioning

confidence: 99%

Download Sinonasal morbidity following tumour resection with and without nasoseptal flap reconstruction

Harvey

Malek

Winder

et al. 2015

Rhin

View full text Add to dashboard Cite

show abstract

Section: The Influence Of Olfactory Apparatus Removalmentioning

confidence: 99%

Download Sinonasal morbidity following tumour resection with and without nasoseptal flap reconstruction

Harvey

Malek

Winder

et al. 2015

Rhin

View full text Add to dashboard Cite

show abstract

“…To compensate for the severity of radiation pneumonitis, we only conducted comparisons between the acetylcysteine and control groups in patients who received steroid therapy for radiation pneumonitis. As a study by Yin et al suggested that the mucociliary system recovers within three months to one year of damage onset and because the antioxidant effect could be diminished after the termination of pathological processes, 13 we excluded patients with an interval between diagnosis of radiation pneumonitis and use of nebulized acetylcysteine of > 1 year. A clinician evaluated the extensiveness of radiation pneumonitis on CT.…”

Section: Control Group Informationmentioning

confidence: 99%

Efficacy of nebulized acetylcysteine for relieving symptoms and reducing usage of expectorants in patients with radiation pneumonitis

et al. 2018

View full text Add to dashboard Cite

BackgroundRadiation pneumonitis is one of the most harmful and clinically significant complications of radiotherapy. This study investigated the benefits of nebulized acetylcysteine for lung cancer patients diagnosed with radiation pneumonitis after radiotherapy.MethodsWe prospectively enrolled and followed 25 patients with radiation pneumonitis who used nebulized acetylcysteine three times a day for 12 weeks. We also reviewed the medical records of 106 control patients who had undergone radiotherapy for lung cancer but had not used acetylcysteine. We evaluated the effects of nebulized acetylcysteine by comparing visits 1 and 4 among nebulizer users and by comparing the acetylcysteine group with the control group.ResultsTwenty‐five acetylcysteine group patients and 101 control group patients were included in the analyses. The mean patient‐rated severity score associated with sputum production decreased in the acetylcysteine group between visits 1 and 4 (from 1.10 to 0.95; P = 0.08). None of the patients used additional expectorant agents after using nebulized acetylcysteine and critical adverse events were not reported. The acetylcysteine group had a shorter mean duration of expectorant use among patients whose radiation pneumonitis required steroid therapy and covered > 10% of a single lung field on computed tomography (37.2 vs. 78.1 days, respectively; P = 0.07).ConclusionsThe beneficial effects of nebulized acetylcysteine for patients with radiation pneumonitis included relieving sputum severity and minimizing expectorant use, especially in severe cases. Further investigation is required to clarify and expand on the benefits of nebulized acetylcysteine for patients with radiation pneumonitis.

show abstract

“…Abnormal ciliary ultrastructure and mucociliary function were widely found in the nasal epithelium of NPC patients after RT, which is the leading cause of CRSr [5][6][7]. Unlike conventional CRS, the treatment of CRSr remains a challenge on account of the lack of effective method to restore the structure and function of irradiated nasal epithelium.…”

Section: Introductionmentioning

confidence: 99%

p63+Krt5+ Basal Cells are Increased in the Squamous Metaplastic Epithelium of Patients with Radiation-induced Chronic Rhinosinusitis

Huang

Tan

Zhou

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Squamous metaplasia (SM) is an irreversible form of airway epithelial remodeling. Hyperproliferation of basal cells was observed in squamous metaplastic epithelium of chronically inflamed airway. However, the association of such aberrant proliferation of basal cells with SM in the nasal epithelium after radiation damage remains unclear. The aim of this study was to investigate SM and accompanying levels of p63+Krt5+ (basal cell markers) cells in the nasal epithelium of patients with radiation-induced chronic rhinosinusitis (CRSr) and patients with chronic rhinosinusitis without nasal polyps (CRSsNP) compared to healthy controls.Methods: We assessed the prevalence of SM and the expression of p63+, Krt5+, p63+Krt5+, and Ki67+ cells through immunofluorescence(IF) staining of the inferior turbinate (IT) tissues from patients with CRSr (n = 36) , CRSsNP (n = 33) and controls (n = 28).Results: The prevalence of SM and the number of p63+Krt5+ cells were both significantly increased in patients with CRSr compared to patients with CRSsNP and controls. The number of Ki67+ cells were both significantly increased in patients with CRSr and CRSsNP compared to controls, but the ratio of Ki67+ cells to p63+Krt5+ cells was significantly lower in patients with CRSr compared to patients with CRSsNP. In patients with CRSr, an increased number of p63+Krt5+ basal cells was observed in SM epithelium compared to non-SM epithelium.Conclusion: SM is increased in the nasal epithelium of patients with CRSr, in which aberrant levels of p63+Krt5+ basal cells serves as an important pathologic feature in the squamous metaplastic epithelium.

show abstract

Damage of nasal mucociliary movement after intensity-modulated radiation therapy of nasopharyngeal carcinoma

Cited by 16 publications

References 0 publications

Download Sinonasal morbidity following tumour resection with and without nasoseptal flap reconstruction

Download Sinonasal morbidity following tumour resection with and without nasoseptal flap reconstruction

Efficacy of nebulized acetylcysteine for relieving symptoms and reducing usage of expectorants in patients with radiation pneumonitis

p63+Krt5+ Basal Cells are Increased in the Squamous Metaplastic Epithelium of Patients with Radiation-induced Chronic Rhinosinusitis

Contact Info

Product

Resources

About