2018
DOI: 10.1007/s00784-018-2381-6
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Damage-regulated autophagy modulator 1 in oral inflammation and infection

Abstract: DRAM1 might be a promising target in future diagnostic and treatment strategies for periodontitis.

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Cited by 22 publications
(20 citation statements)
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“…And in vivo, DRAM1 expression was also significantly enhanced in rat and human gingival tissues with periodontitis, compared to that in healthy gingiva (Memmert et al, 2018).…”
Section: Autophagy and Periodontal Infl Ammationmentioning
confidence: 91%
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“…And in vivo, DRAM1 expression was also significantly enhanced in rat and human gingival tissues with periodontitis, compared to that in healthy gingiva (Memmert et al, 2018).…”
Section: Autophagy and Periodontal Infl Ammationmentioning
confidence: 91%
“…DRAM1 is a lysosomal membrane protein regulated as part of the p53 signal transduction pathway and promotes the induction of autophagy in a p53‐dependent manner (Crighton et al, ; Crighton, Wilkinson, & Ryan, ). The expression of DRAM1 was up‐regulated under inflammatory conditions in human periodontal ligament fibroblasts stimulated by IL‐1β in vitro (Memmert et al, ). And in vivo, DRAM1 expression was also significantly enhanced in rat and human gingival tissues with periodontitis, compared to that in healthy gingiva (Memmert et al, ).…”
Section: Autophagy and Periodontal Inflammationmentioning
confidence: 99%
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“…Gingival biopsies of 7 periodontally healthy donors (mean age: 22.1 years, min–max: 18–26 years; gender: 2 male/5 female) and 7 periodontally-diseased patients (mean age: 58.4 years, min–max: 29–81 years; gender: 5 male/2 female) were used for our experiments. These biopsies were obtained during wisdom tooth extraction and extractions for orthodontic or periodontal reasons in the Department of Oral Surgery of the University of Bonn [44]. Written and informed consent by the subjects and approval by the Ethics Committee of the University of Bonn (#043/11) were provided.…”
Section: Materials Und Methodsmentioning
confidence: 99%
“…No clinical inflammation (GI = 0), a PD below 3 mm and neither clinical nor radiographic bone loss were categorized as periodontally healthy. Periodontitis patients were identified by sites with a GI > 1 and PD ≥ 5 mm and clinical as well as radiographic bone loss ≥3 mm, as previously described [21, 44, 45]. Smokers as well as patients taking any medication were excluded from the study.…”
Section: Materials Und Methodsmentioning
confidence: 99%