1967
DOI: 10.1007/bf00306453
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Damage to deoxyribose molecules and to U-gene reactivation in UV-irradiated 5-bromouracil-DNA of phage T4 Bo ras influenced by cysteamine

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Cited by 48 publications
(11 citation statements)
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“…This applies to damage resulting both in a loss of plaque-forming ability, probably due to base damage, and in double-strand breaks of the BU-DNA. It was pointed out that a correlation might exist between the protective effect of cysteamine with respect to BU-damage and the ability of the host cell to reactivate radiation damage in BU-phage [4,17]. This hypothesis was recently supported by experimental evidence furnished by Radman and collaborators [19].…”
Section: Discussionmentioning
confidence: 94%
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“…This applies to damage resulting both in a loss of plaque-forming ability, probably due to base damage, and in double-strand breaks of the BU-DNA. It was pointed out that a correlation might exist between the protective effect of cysteamine with respect to BU-damage and the ability of the host cell to reactivate radiation damage in BU-phage [4,17]. This hypothesis was recently supported by experimental evidence furnished by Radman and collaborators [19].…”
Section: Discussionmentioning
confidence: 94%
“…(iii) Chemical compounds of the cysteine-cysteamine group are known to provide effective protection from ionizing radiation [2]. However, these substances do not protect the biological activity of unsubstituted phage Tl [3], T4B oT [4], T2, T4, T4x (Rotz, unpublished results), andcf>X-174 [17] with respect to u.v.-radiation. The formation of cross-links in DNA after the irradiation ofunsubstituted phage is likewise not influenced by the presence ofO'OIM cysteamine.…”
Section: Discussionmentioning
confidence: 99%
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