2014
DOI: 10.4137/mri.s19750
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Damage to the Optic Chiasm in Myelin Oligodendrocyte Glycoprotein–Experimental Autoimmune Encephalomyelitis Mice

Abstract: Optic chiasm lesions in myelin oligodendrocyte glycoprotein (MOG)–experimental autoimmune encephalomyelitis (EAE) mice were characterized using magnetic resonance imaging (MRI) and validated using electron microscopy (EM). MR images were collected from 3 days after induction to remission, approximately 20 days after induction. Hematoxylin and eosin, solochrome cyanin–stained sections, and EM images were obtained from the optic chiasms of some mice approximately 4 days after disease onset when their scores were… Show more

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Cited by 6 publications
(6 citation statements)
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“…Similar to findings in human studies, alterations in the retina [8, 9], optic nerve [1013], tract [11, 12], chiasm [14], and radiations [15] have been reported in mouse models of MS. Approximately 70–92% of eyes develop ON 11 days post immunisation (dpi) in experimental ON mouse models, making it ideal for investigating visual pathway dysfunction [11, 16, 17].…”
Section: Introductionsupporting
confidence: 73%
“…Similar to findings in human studies, alterations in the retina [8, 9], optic nerve [1013], tract [11, 12], chiasm [14], and radiations [15] have been reported in mouse models of MS. Approximately 70–92% of eyes develop ON 11 days post immunisation (dpi) in experimental ON mouse models, making it ideal for investigating visual pathway dysfunction [11, 16, 17].…”
Section: Introductionsupporting
confidence: 73%
“…WMH is commonly detected in the CNS of EAE animals. These lesions, which are observed to precede the onset of clinical signs (Chuhutin et al, 2020; Waiczies et al, 2012), are spotted in the periventricular WM, in the CC, in the thalamus, in the hippocampus (Belloli et al, 2018; Boretius et al, 2012), in the optic tract (Herrera et al, 2014), in the spinal cord (Mori et al, 2014), and the cerebellum (Belloli et al, 2018; Waiczies et al, 2012) (Figure 2). Histopathological analysis of spinal cords and brains confirmed the association between the radiological outcomes and neuropathological features.…”
Section: Mri Studies In Ms Mouse Modelsmentioning
confidence: 99%
“…Histopathological analysis of spinal cords and brains confirmed the association between the radiological outcomes and neuropathological features. The pathological changes with EAE progression were examined for inflammation, for example, hematoxylin and eosin (H&E), T‐cell infiltration (CD4 and CD3) and immunoglobulins, activation of microglia/macrophages (Iba1 and Mac3), and astrogliosis (GFAP), as well as demyelination (MBP and luxol fast blue‐LFB) and acute axonal damage (amyloid precursor protein‐APP) (Belloli et al, 2018; Boretius et al, 2012; Herrera et al, 2014; Waiczies et al, 2012).…”
Section: Mri Studies In Ms Mouse Modelsmentioning
confidence: 99%
“…A rare aetiology like chronic chiasmal arachnoiditis can only be suspected by alteration in dimensions of optic chiasma where presence of fibrous cicatricial bands causes chiasmal compression. (16) However, chiasmal neuritis (17) resulting from aetiologies ranging from idiopathic, demyelinating disease, (17,18) infections, etc. cannot be confirmed by chiasmal measurements.…”
Section: Slmentioning
confidence: 99%