Dandy-Walker Malformation Presenting with Psychological Manifestations

Rohanachandra, Yasodha Maheshi; Dahanayake, Dulangi; Wijetunge, Swarna

doi:10.1155/2016/9104306

Cited by 10 publications

(10 citation statements)

References 16 publications

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“…Psychotic cases were generally associated with Dandy-Walker syndrome, MCM, or DWV. Other psychiatric disorders associated with posterior fossa abnormalities include obsessive-compulsive disorder [33, 39, 50], posttraumatic stress disorder [47], attention deficit hyperkinetic disorders [51, 52], manic episodes [38, 53, 54], bipolar disorder [55-59], impulsive behavior associated with recurrent major depression [60], or recurrent catatonia [38, 61]. …”

Section: Discussionmentioning

confidence: 99%

Dandy-Walker Malformation-Like Condition Revealed by Refractory Schizophrenia: A Case Report and Literature Review

et al. 2018

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Introduction: Dandy-Walker malformation is a rare congenital malformation involving cystic dilatation of the fourth ventricle, enlarged posterior fossa, complete or partial agenesis of the cerebellar vermis, elevated tentorium cerebelli, and hydrocephalus. Previous research highlighted a possible role for the cerebellum in schizophrenia as well as the contribution of underlying brain malformations to treatment resistance. Here, we present a case of a Dandy-Walker malformation-like condition revealed by a refractory schizophrenia in a 24-year-old male patient. We also conduct a literature review of all previously published case reports or case series of co-occurring posterior fossa abnormalities and schizophrenia or psychosis using a PubMed search query to better understand the potential link between these two disorders. Case Presentation: A 9-month hospital stay was needed to address the treatment-resistant psychotic symptoms, and the patient continued to experience moderate symptoms despite the prescription of various antipsychotic and antidepressant medications. After an irregular initial medical follow-up, the patient is currently treated with 350 mg daily clozapine and 20 mg daily prazepam and still exhibits moderate anxiety without delirious thoughts, however allowing him to re-enroll at the university. Regarding the literature, 24 cases published between 1996 and 2017 were identified, reviewed and compared to the present case report. Discussion: This case report and literature review further illuminates the pathophysiology of psychotic disorders including the potential role of the cerebellum, reinforces the importance of a multidisciplinary approach for the neurological and psychiatric management of patients with schizophrenia, and highlights optimal pharmacological management strategies for treatment-resistant schizophrenia.

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Section: Discussionmentioning

confidence: 99%

Dandy-Walker Malformation-Like Condition Revealed by Refractory Schizophrenia: A Case Report and Literature Review

et al. 2018

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“…To the best of our knowledge, only few case reports described DWM with impulsive and destructive behavior. 10 , 11 …”

Section: Introductionmentioning

confidence: 99%

“…To the best of our knowledge, only few case reports described DWM with impulsive and destructive behavior. 10,11 According to the Diagnostic and Statistical Manual of Mental Disorders (5th ed. ; DSM-5), intermittent explosive disorder is characterized by impulsive and aggressive outbursts, which might be verbal or physical.…”

Section: Introductionmentioning

confidence: 99%

“…3 Several case reports have linked DWM to psychotic symptoms, obsessive-compulsive symptoms, mood disorders, and hyperactivity. [4][5][6][7][8][9] We performed an extensive literature review using the PubMed, PsycInfo, and Google Scholar databases. To the best of our knowledge, only few case reports described DWM with impulsive and destructive behavior.…”

Section: Introductionmentioning

confidence: 99%

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Dandy–Walker malformation and intermittent explosive disorder: A case report

Tahir

Ahmed

Salman

et al. 2022

SAGE Open Medical Case Reports

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Dandy–Walker malformation is a group of brain malformations that sometimes present with psychotic features, violent and impulsive behavior, or mood symptoms. Here, we present a case report of a patient with Dandy–Walker malformation who presented with intermittent explosive disorder. A young man, aged 18 years, was brought to the author’s hospital [Hamad Medical Corporation] with anger outbursts, irritable mood, and violent behavior. His magnetic resonance imaging scans showed typical alterations of Dandy–Walker malformation. He also had mild intellectual disabilities and epilepsy. After a few weeks of treatment with sodium valproate 1000 mg/day and risperidone 2 mg/day, his condition improved, and his violent behavior was significantly reduced in 3 months, 6 months, and 1 year of follow-up. There is broad consensus that Dandy–Walker malformation is associated with psychosis and other behavioral abnormalities because of a possible disruption in the prefrontal, thalamic, and cerebellar circuits. The link between Dandy–Walker malformation and intermittent explosive disorder may help us understand this type of brain malformation as a potential psychiatric comorbidity.

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“…La variante Dandy-Walker (DW), diagnostico que recibe nuestro paciente, es un término cuestionado puesto que se han descrito bajo este epígrafe múltiples variantes con características muy distintas: Hipoplasia del vermix cerebeloso asociada a dilatación del cuarto ventrículo, pero sin alargamiento de la fosa posterior (2), ausencia de hidrocefalia (3) y pacientes con clínica neurológica más leve, con más complicaciones psicológicas (psicosis, trastornos afectivos, trastorno obsesivo-compulsivo e hiperactividad entre otros) y con peor respuesta al tratamiento farmacológico (3). Las revisiones sistemáticas (2) señalan que la ausencia de criterios unificados a la hora de definir la malformación de DW y su variante y, como resultado, se describen poblaciones heterogéneas con resultados no generalizables.…”

Section: Introductionunclassified

Psicopatología asociada al complejo Dandy Walker: descripción de un caso

Miralles

Poveda

Pacheco

2020

Rev Psiquiatr Infanto-Juv

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La malformación de Dandy Walker (DW) es una malformación cerebelosa asociada a múltiples déficits cognitivos, alteraciones psicopatológicas y alteraciones motoras. Presentamos el caso de un paciente afectado de esta malformación y derivado a la unidad de salud mental infantil por presentar psicopatología asociada. Realizamos una revisión sobre la epidemiología, la clínica, el pronóstico y la comorbilidad propia de esta malformación así como sobre la psicopatología asociada a la patología cerebelosa en su conjunto, incluyendo el síndrome cerebeloso cognitivo-afectivo de Shamahmann y Sherman. Por último, incluimos la descripción del caso y establecemos el diagnóstico diferencial a partir de la historia del paciente, la exploración del estado mental y el análisis de las exploraciones complementarias (radiológicas y neuropsicológicas).

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Dandy-Walker Malformation Presenting with Psychological Manifestations

Cited by 10 publications

References 16 publications

Dandy-Walker Malformation-Like Condition Revealed by Refractory Schizophrenia: A Case Report and Literature Review

Dandy-Walker Malformation-Like Condition Revealed by Refractory Schizophrenia: A Case Report and Literature Review

Dandy–Walker malformation and intermittent explosive disorder: A case report

Psicopatología asociada al complejo Dandy Walker: descripción de un caso

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